Comparison of the effects of peficitinib and tofacitinib in the adjuvant-induced arthritis rat model

Ishikawa, Go; Kwon, Chulwon; Fujii, Yasutomo

doi:10.1016/j.ejphar.2023.175490

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…The JAK pathway is triggered by various pro-inflammatory cytokines and the pathway in turn results in the production of more cytokines and this vicious cycle contributes to the severity of the disease. This was supported by observing the reduction in disease severity and joint destruction on treatment with JAK inhibitors like tofacitinib and peficitinib (Ishikawa et al, 2023). The profusion of cytokines that are circulated during RA advancement is perceived by nociceptive receptors and this phenomenon induces the sensation of pain.…”

Section: Jak-signal Transducer and Activator Of Transcription Pathwaymentioning

confidence: 90%

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Chatterjee,

Jayaprakasan,

Chakrabarty

et al. 2024

Phytotherapy Research

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Rheumatoid arthritis is a chronic autoimmune inflammatory disease characterized by immune response overexpression, causing pain and swelling in the synovial joints. This condition is caused by auto‐reactive antibodies that attack self‐antigens due to their incapacity to distinguish between self and foreign molecules. Dysregulated activity within numerous signalling and immunological pathways supports the disease's development and progression, elevating its complexity. While current treatments provide some alleviation, their effectiveness is accompanied by a variety of adverse effects that are inherent in conventional medications. As a result, there is a deep‐rooted necessity to investigate alternate therapeutic strategies capable of neutralizing these disadvantages. Medicinal herbs display a variety of potent bioactive phytochemicals that are effective in the complementary management of disease, thus generating an enormous potency for the researchers to delve deep into the development of novel phytomedicine against autoimmune diseases, although additional evidence and understanding are required in terms of their efficacy and pharmacodynamic mechanisms. This literature‐based review highlights the dysregulation of immune tolerance in rheumatoid arthritis, analyses the pathophysiology, elucidates relevant signalling pathways involved, evaluates present and future therapy options and underscores the therapeutic attributes of a diverse array of medicinal herbs in addressing this severe disease.

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Section: Jak-signal Transducer and Activator Of Transcription Pathwaymentioning

confidence: 90%

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Chatterjee,

Jayaprakasan,

Chakrabarty

et al. 2024

Phytotherapy Research

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show abstract

Peficitinib halts acute kidney injury via JAK/STAT3 and growth factors immunomodulation

Ibrahim,

Sharawy,

Hamed

et al. 2024

European Journal of Pharmacology

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Locally immunological effects of honey applications in patients with rheumatoid arthritis

Saeed,

Kadhim,

Alsaadawi

et al. 2024

Transport, Ecology, Sustainable Development: Eko Varna 2023

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Comparison of the effects of peficitinib and tofacitinib in the adjuvant-induced arthritis rat model

Cited by 3 publications

References 35 publications

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Peficitinib halts acute kidney injury via JAK/STAT3 and growth factors immunomodulation

Locally immunological effects of honey applications in patients with rheumatoid arthritis

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