Comparison of the effects of bicuculline and strychnine on brain stem auditory evoked potentials in the cat

Martin, Michael R.; Penix, LaRoy

doi:10.1111/j.1476-5381.1983.tb09364.x

Cited by 7 publications

(1 citation statement)

References 12 publications

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“…It is very likely that GABA A receptors are involved in inhibition in the CN, as GABA-mediated inhibition of spontaneous and tone-evoked activity of CN neurons is selectively blocked by bicuculline [15,16,18,19,25], which also alters auditory evoked potentials [47].…”

Section: Introductionmentioning

confidence: 99%

Distribution of GABAA and GABAB binding sites in the cochlear nucleus of the guinea pig

et al. 1994

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We compared the distribution of GABAA and GABAB binding sites in the cochlear nucleus using quantitative receptor autoradiography with [3H]GABA. To visualize GABAA binding sites, GABAB binding sites were blocked with +/- baclofen. To visualize GABAB binding sites, isoguvacine was used to block GABAA binding sites. GABAA binding sites predominated over GABAB, although there were marked regional differences in the distribution of binding. In the ventral cochlear nucleus, GABAA and GABAB binding sites were concentrated in the peripheral granule cell cap, with low binding levels in the central region. In the dorsal cochlear nucleus, binding was concentrated in the superficial (fusiform and molecular) layers, with a distinct laminar pattern. GABAA binding sites predominated in the fusiform cell layer. The molecular layer contained the highest level of GABAB binding sites in the entire cochlear nucleus. These results suggest that GABAergic inhibition in the cochlear nucleus is mediated both by GABAA and GABAB receptors, particularly in the dorsal cochlear nucleus. However, low levels of binding in areas such as the magnocellular regions of the ventral cochlear nucleus, known to contain abundant GABAergic synapses, suggest heterogeneity of GABA receptors in this auditory nucleus.

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Section: Introductionmentioning

confidence: 99%

Distribution of GABAA and GABAB binding sites in the cochlear nucleus of the guinea pig

et al. 1994

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Three classes of inhibitory amino acid terminals in the cochlear nucleus of the guinea pig

et al. 1996

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Electron microscopic postembedding immunocytochemistry was used to analyze and assess the synaptic distribution of glycine (GLY) and gamma-amino butyric acid (GABA) immunoreactivities in the guinea pig cochlear nucleus (CN). Three classes of endings were identified containing immunolabeling for glycine, GABA, or both glycine and GABA (GLY/GABA). All classes were similar in that the terminals contained pleomorphic vesicles and formed symmetric synapses with their postsynaptic targets. A fourth class, which labeled with neither antibody, contained round vesicles and formed asymmetric synapses. Glycine endings predominated in the ventral CN, while GLY/GABA endings were prevalent in the dorsal CN. GABA endings were the least common and smallest in size. Glycine, GLY/GABA, and GABA endings differed in their proportions and patterns of distribution on the different classes of projection neurons in the CN, including spherical bushy, type I stellate/multipolar, and octopus cells in the ventral CN and fusiform cells in the dorsal CN. The vast majority of anatomically-defined, putative inhibitory endings contain GLY, GABA, or both, suggesting that most of the inhibition in the cochlear nucleus is mediated by these three cytochemically and, probably, functionally distinct classes of endings. The results of this study also suggest that a large proportion of the GABA available for inhibition in the CN coexists in terminals with glycine.

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Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor

Betz²,

et al. 1986

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Comparison of the effects of bicuculline and strychnine on brain stem auditory evoked potentials in the cat

Cited by 7 publications

References 12 publications

Distribution of GABAA and GABAB binding sites in the cochlear nucleus of the guinea pig

Distribution of GABAA and GABAB binding sites in the cochlear nucleus of the guinea pig

Three classes of inhibitory amino acid terminals in the cochlear nucleus of the guinea pig

Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor

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