Comparison of the effects of lidocaine and fentanyl in epidural anesthesia in dogs

Abstract

Abstract:The study included 12 clinically healthy, adult male dogs of various breeds, admitted to our clinic for castration. After general anesthesia with sevofl urane, we administered epidural fentanyl (1 mcg/kg) to fentanyl group, while lidocaine group was given Lidocaine (3 mg/kg) through epidural administration. When hemodynamic parameters were stabilized, fi rst measurements were recorded at minutes 0, 15, 30, 60 in both groups, which included Heart Rate (HR), body temperature, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), sodium (Na + ), potassium (K + ), glucose (GLC), and hemoglobin (HB) measurements. In addition, serum samples were obtained from arterial blood at the same measurement times, and pH, pO 2 , pCO 2 , HCO 3 , %O 2 Saturation, BE levels were measured. For hematological analysis, WBC, RBC, HCT, THR counts were performed. For serum biochemical analysis, venous blood samples were collected at minutes 0 and 60 and CK, TP, UREA, ALT, AST, ALB, GGT, CRE, CK-MB parameters were assessed using auto-analyzer. Moreover, cortisol levels were measured in the samples collected at minutes 0, 30, and 60. Mean arterial blood pressure values measured at minutes 15, 30 and 60 were found signifi cantly lower in the fentanyl group (p<0.01). In conclusion, we suggest that epidural anesthesia with lidocaine and fentanyl can provide an effective and safe option in high-risk groups (Tab. 5, Fig. 1, Ref. 24). Text in PDF www.elis.sk.

Inadvertent Perianesthetic Hypothermia in Small Animal Patients

“…Most agents used to provide general anesthesia, regional anesthesia, analgesia, or immobilization have been shown to negatively affect thermoregulation. 16,17 Epidural and spinal anesthesia decrease the ability of the thermal centers in the brain to register a decrease in body temperature, as a result, appropriate responses to hypothermia (vasoconstriction, shivering) are blunted. Inhalant anesthetics cause dose-dependent vasodilation and increase the pooling of blood in the peripheral tissues.…”

An Update on Drugs Used for Lumbosacral Epidural Anesthesia and Analgesia in Dogs

“…Highly lipophilic drugs, such as fentanyl and meperidine have a shorter latency and duration of action (73, 77, 78). Lipophilicity can increase uptake into the adipose tissue of the epidural space, the degree of which will depend on the quantity of fat around the epidural space.…”