Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury

Erol, Fatih Serhat; Kaplan, Metin; Tiftikci, Murat; Yakar, Hüseyin; Özercan, İbrahim Hanifı; İlhan, Necip; Topsakal, Cahide

doi:10.1016/j.jocn.2007.06.009

Cited by 32 publications

(23 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have recently reported Octreotide and melatonin In a rat model of SCI Melatonin was found to be superior to octreotide to attenuate the SCI. 104 Lecithinized superoxide dismutase In a rat model of SCI Lecithinized superoxide dismutase suppressed neuronal death through reducing oxidative stress. 105 Polyunsaturated fatty acids.…”

Section: Nucleusmentioning

confidence: 99%

Oxidative stress in spinal cord injury and antioxidant-based intervention

Jia

Zhu

Li³

et al. 2011

Spinal Cord

267

176

View full text Add to dashboard Cite

Study design: Literature review. Objectives: Spinal cord injury (SCI) remains a major public health issue in developed countries as well as worldwide. The pathophysiology of SCI is characterized by an initial primary injury followed by secondary deterioration. Although the etiology and pathogenesis of SCI remain to be fully understood, it has been suggested that reactive oxygen species (ROS) and oxidative stress have a significant role in the pathophysiology of SCI. Thus, alleviating oxidative stress may be an effective strategy for therapeutic intervention of SCI. The aim of this review was to describe (i) the sources of ROS as well as the major antioxidant defenses with particular attention being paid to lipid peroxidation; (ii) the biomarkers of oxidative stress in SCI and (iii) the neuroprotective effects of various compounds with antioxidative properties in animal models of SCI. Methods: PubMed, one of the most comprehensive biomedical databases, was searched from 1976-2011. All relevant papers were read by title, abstract and full-length article. Results: Oxidative stress is considered a hallmark of injury of SCI. Thus, alleviating oxidative stress may be an effective way of therapeutic intervention of SCI. Two of these agents, the glucocorticoid steroid methylprednisolone and the non-glucocorticoid 21-aminosteroid tirilazad, have been shown to possess significant antioxidant activities and improve recovery of SCI patients in clinical trials. Other promising botanical compounds and their molecular targets and mechanisms of action with regard to potential protection against SCI were also described. These include carotenoids and phenolic compounds. Conclusion: ROS and oxidative stress have a significant role in the pathophysiology of SCI. Alleviating oxidative stress is be an effective strategy for therapeutic intervention of SCI. Extensive research over the past several decades has identified numerous bioactive compounds that have antioxidative stress benefits in animal models of SCI. Thus, continued studies on bioactive compounds with ROS-scavenging capacity may lead to the development of effective antioxidant-based modalities for treating SCI in human subjects.

show abstract

Section: Nucleusmentioning

confidence: 99%

Oxidative stress in spinal cord injury and antioxidant-based intervention

Jia

Zhu

Li³

et al. 2011

Spinal Cord

267

176

View full text Add to dashboard Cite

show abstract

“…38 Erol et al observed that both MLT and octreotide gave benefits in an spinal cord injury (SCI) model, and MLT had the more pronounced beneficial effect. 39 Their biochemical and histopathological findings were correlated and significant. 39 For this reason, MLT and octreotide could have the potential to upregulate antioxidant defense systems and be beneficial for patients who sustain SCI.…”

Section: Free Radical Scavenging Effects Of Melatonin In Peripheral Nmentioning

confidence: 97%

“…39 Their biochemical and histopathological findings were correlated and significant. 39 For this reason, MLT and octreotide could have the potential to upregulate antioxidant defense systems and be beneficial for patients who sustain SCI. 39,40 I/R produces free radicals leading to lipid peroxidation and nervous tissue injury.…”

Section: Free Radical Scavenging Effects Of Melatonin In Peripheral Nmentioning

confidence: 97%

“…39 For this reason, MLT and octreotide could have the potential to upregulate antioxidant defense systems and be beneficial for patients who sustain SCI. 39,40 I/R produces free radicals leading to lipid peroxidation and nervous tissue injury. The free radical scavenging and antioxidant effects of MLT have been shown to diminish I/R injury in many tissues.…”

Section: Free Radical Scavenging Effects Of Melatonin In Peripheral Nmentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2017

J Brachial Plex Peripher Nerve Inj

View full text Add to dashboard Cite

“…All these parameters were calculated in terms of the percentage of the damaged surface, and the classification used was as follows: 0 (no damage), 1 (slight) ≤5%, 2 (minimal) 6-20%, 3 (moderate) 21-50%, 4 (severe) 51-75%, and 5 (very severe) 76-100%. [12] …”

Section: Pathological Investigationmentioning

confidence: 99%