Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery

The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal

“…Both drugs were equally effective for trismus control. The measurements of facial swelling found in the study of Üstün et al (2), who prescribed two different doses of a corticosteroid for swelling control, were very similar to ours both on the 2nd and 7th postoperative days (about 7 and 3 mm, respectively). Corticosteroids are well known as potent drugs widely used to decrease the swelling related to third molar surgery (2,24).…”

“…The following parameters were assessed: duration of the surgery after anesthetic administration (in minutes), which corresponded to the period between the first incision and the last suture (2,5,6); subjective postoperative pain evaluation with the aid of a 100-mm length visual analogue scale, with 0 corresponding to "no pain" and 100 corresponding to "worst pain imaginable" (5,6,13); subjects recorded the intensity of postoperative pain at 15-min intervals for the first 60 postoperative minutes, and 1.5, 2, 3, 4, 5, 6, 7, 8, 10, 12, 16, 24 (6,13,25), 48, 72, and 96 h (6) after the end of surgery; mouth opening (distance, in mm, between the mesial-incisal corners of the upper and lower right central incisors at maximum opening of the jaws) before surgery and at the time of suture removal (7 days postoperatively); the postoperative ability to open the mouth was expressed as a percentage of the preoperative measure (2,5,6); incidence, type and severity of adverse reactions (gastrointestinal irritation, nausea, vomiting, bleeding, allergy, headache, dizziness, sleepiness, and any other kinds of reaction) (5,6,13); total amount of rescue analgesic medication (paracetamol, in mg) needed during the postoperative period, and facial swelling determined by a tape-measuring method on the 2nd and 7th postoperative days (2). This method takes V. Benetello et al…”

“…Frequently, this is a short-lasting and moderate pain, reaching its maximum intensity within a short period of time after the end of surgery, and, in most cases, patients require some kind of analgesic to treat it (1). Besides pain, swelling and mouth opening limitation associated with the inflammatory response are also undesirable consequences for patients who undergo surgical interventions in the oral cavity (2).…”

“…Several non-steroidal anti-inflammatory drugs (NSAIDS) have been used for pain, trismus and swelling control after lower third molar surgeries (2)(3)(4)(5)(6). The therapeutic effect of these medications is based on the inhibition of cyclooxygenases (COX), which determines an inhibition of prostaglandin production (7).…”

Evaluation of Complications Following Impacted Mandibular Third Molar Extraction in Patients with Different Hand Preference

“…Pain, edema, and trismus after the extraction of impacted third molars are expected outcomes and these complications adversely affect the daily life of patients (17,18,19). Many studies have suggested that corticosteroids, different anesthetics, pain killers, and anti-inflammatory drugs may reduce the severity of these complications (20,21).…”