Comparison of the effects of oral iron treatment every day and every other day in female patients with iron deficiency anaemia

Abstract

BackgroundIt is known that daily divided doses and high doses of iron increase hepcidin and reduce iron absorption.AimTo compare treatments of iron replacement every other day at low doses, once a day and twice a day in terms of their effectiveness and frequencies of side‐effects.MethodsFor 1 month, Group I received 270 mg ferrous sulphate twice a day (total elemental iron dose: 160 mg/day), Group II received 270 mg ferrous sulphate once a day (total elemental iron dose: 80 mg/day), and Group III received 270 mg ferrous sulphate every other day (total elemental iron dose: 80 mg/every other day). Intragroup and intergroup statistical analyses were carried out.ResultsHaemoglobin (Hb) increased significantly in all three groups (P = 0.00). The increase in Hb levels was similar among the groups (P = 0.09). Ferritin significantly increased in all three groups after the treatment (P = 0.00). The increase in ferritin in Group I was significantly higher than those in Groups II and III (P < 0.05). Gastrointestinal tract (GIS) side‐effects were also significantly higher in Group I in comparison to the others (P = 0.001).ConclusionsA low dosage of iron treatment every other day may be used in the place of providing iron once or twice every day with similar effectiveness and lower rates of GIS side‐effects.

Efficacy and Mechanism of Roxadustat plus Oral Iron in the Treatment of Elderly Chronic Kidney Disease with Anemia

“…The results may attributed to the fact that Roxadustat can reduce the hepcidin of the patient's body, thereby increasing the TRF level of the patient's body and helping the patient to stabilize the body's Fe level [ 14 , 15 ]. Rubeor et al revealed that the level of inflammatory factors in patients with CKD and anemia may have a certain relationship with the disease, and over half of the patients are accompanied by active inflammatory response [ 16 , 17 ]. de Lecea have found that inflammatory factors can increase the level of hepcidin in the patient's body, thereby inhibiting the production of EPO in the patient's kidneys, and aggravating the anemia [ 18 ].…”

Iron supplementation in women: impact of frequency on efficacy and tolerability

“…GI side effects (nausea and abdominal pain) were comparable between the two groups (P = 0.57). 10 A randomised controlled study by Düzen Oflas et al 11 included 150 participants and compared AD, CD, and BD dosing of ferrous sulphate over 1 month. Fifty participants received 80 mg of elemental iron twice daily (total daily dose = 160 mg), 50 received 80 mg daily, and the remaining 50 received 80 mg every other day.…”

“…In summary, two studies reported that AD dosing offered better absorption than CD dosing, 7,10 while another study and metaanalysis concluded that AD dosing may offer comparable efficacy. 11,12 Kaundal et al 9 concluded that, while BD dosing achieved study endpoints more quickly, AD dosing reached the same markers soon after. Of note, evidence to date indicated fewer GI side effects with AD dosing.…”

“…Of note, evidence to date indicated fewer GI side effects with AD dosing. 7,[9][10][11][12] Although the overall conclusion is that AD dosing offers similar or better clinical response, further research could provide more certainty. The studies mentioned above include relatively small population groups and differing doses of elemental iron and efficacy measures.…”

Iron-Enriched Nutritional Supplements for the 2030 Pharmacy Shelves

“…Amon the plethora of so-called superfoods only few of them combine high iron content and anti-inflammatory properties. It is important, indeed, to consider the anti-inflammatory potential of those foods to compensate for possible deleterious effects of high amounts of inorganic iron on the intestinal tract [155][156][157]. Thus, the advantage of administrating balanced supplements releasing iron to the proximal part of the small intestine and, at the same time, provide anti-inflammatory and protective compounds.…”