Comparison of the effects of gonadotropin-releasing hormone, human chorionic gonadotropin or progesterone on pregnancy per artificial insemination in repeat-breeder dairy cows

Khoramian, Babak; Farzaneh, Nima; Garoussi, Massoud Talebkhan; Mohri, Mehrdad

doi:10.1016/j.rvsc.2010.05.025

Cited by 23 publications

(29 citation statements)

References 37 publications

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“…On the other hand, Marques et al (2012) reported that 10 µg of Buserelin given on day 7 of the estrous cycle increased pregnancy rates on crossbred recipients that received frozen-thawed embryos produced in vivo. In agreement with the present findings, Khoramian et al (2011) reported similar pregnancy rates to AI between cows treated with 20 µg of Buserelin, 5-6 days after AI, and untreated controls.…”

supporting

confidence: 92%

Factors Affecting Pregnancy Rates After Ovum Pick Up-Derived Embryo Transfer in Lactating Holstein Recipients Under Tropical Conditions

et al. 2015

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High milk production, heat, physiological status and management impair reproduction in Holstein cows. The use of in vivo-produced embryos has been reported as an alternative to enhance pregnancy outcome in the tropics; however there are several limitations for its production, especially from variations in superovulatory responses. The in vitro production of embryos would avoid such variations, but few studies have been reported. This study aims to verify the effects of variables related to recipients under a program of routine in vitro embryo transfer on a commercial dairy farm in southeastern Brazil. It was hypothesized that pregnancy rates after transfer of ovum pick up or OPU-derived embryos (ET) to lactating Holstein recipients may be influenced by recipient GnRH-treatment at ET, parity, milk production and body condition score. Recipients (267) were allocated to one of three i.m. treatments given at ET: Control (92) -2.5 ml saline; Buserelin (86) -10 μg Buserelin acetate; Deslorelin (89) -750 μg Deslorelin acetate. Ultrasound images and blood samples were taken at ET and seven days later. The first pregnancy diagnosis was performed between 30-40 days and the second between 60-80 days post ET. Data were analyzed by GENMOD (SAS ® ). The proportion of pregnant cows was greater (P<0.05) in Buserelin-treated recipients (38.3%) at the first pregnancy diagnosis than Controls (24.1%), but similar to Deslorelin and control cows at the second diagnosis (13.0, 20.9 and 14.6% in Control, Buserelin and Deslorelin, respectively). In conclusion, Buserelin improved pregnancy rate only transitorily, under the present conditions. Index terms: Bovine; GnRH agonists; progesterone. RESUMOAlta produção leiteira, calor, estado fisiológico e manejo prejudicam a reprodução em vacas Holandesas nos trópicos. A utilização de embriões produzidos in vivo é uma alternativa para melhorar taxas de gestação; no entanto, existem limitações, especialmente pelas variações nas respostas superovulatórias. A produção in vitro de embriões evitaria tais variações, mas poucos estudos estão relatados. O objetivo é verificar os efeitos de variáveis relacionadas às receptoras sob um programa de transferência de embriões (TE) in vitro em fazenda comercial no sudeste do Brasil. Hipotetiza-se que taxas de gestação, após TE de embriões derivados de OPU em receptoras Hosltein em lactação, são influenciadas pelo GnRH aplicado no momento da TE, paridade, produção de leite e escore de condição corporal. As receptoras (267) foram alocadas para um de três tratamentos aplicados no momento da TE: Controle (92) -Salina 2,5 ml; Buserelina (86) -10 µg de buserelina; Deslorelina (89) -750 µg de deslorelina. Ultrassonografia e amostras de sangue realizadas no momento da TE e sete dias depois. O primeiro diagnóstico de gestação foi realizado entre 30-40 dias e o segundo entre 60-80 dias pós-TE. Dados foram analisados pelo GENMOD (SAS ® ). A proporção de vacas prenhes foi superior (P<0,05) nas receptoras tratadas com Buserelina (38,1%) comparadas com Controle (24...

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confidence: 92%

Factors Affecting Pregnancy Rates After Ovum Pick Up-Derived Embryo Transfer in Lactating Holstein Recipients Under Tropical Conditions

et al. 2015

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“…Thus, various investigations of the effects of CIDR treatment post-insemination on subsequent fertility were performed [91216]. In the present study, the serum progesterone concentration was higher in CIDR-treated cows than non-treated control cows on day 5, reaching 2.5 ng/mL ( vs .…”

Section: Discussionmentioning

confidence: 42%

“…However, the timing and duration of such an insertion has been found to vary among studies [192729]. Several studies demonstrated that a CIDR insert increased the circulating progesterone concentration [2410].…”

Section: Introductionmentioning

confidence: 99%

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Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

et al. 2016

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This study investigated the effects of gonadotrophin-releasing hormone (GnRH) administration (Experiment 1) and a controlled internal drug-releasing (CIDR) insert (Experiment 2) after timed artificial insemination (TAI) on the pregnancy rates of dairy cows. In Experiment 1, 569 dairy cows that underwent TAI (day 0) following short-term synchronization with prostaglandin F2α were randomly allocated into two groups: no further treatment (control, n = 307) or injection of 100 µg of gonadorelin on day 5 (GnRH, n = 262). In Experiment 2, 279 dairy cows that underwent TAI (day 0) following Ovsynch were randomly allocated into two groups: no further treatment (control, n = 140) or CIDR insert treatment from days 3.5 to 18 (CIDR, n = 139). The probability of pregnancy following TAI did not differ between the GnRH (34.4%) and control (31.6%, p > 0.05) groups. However, the probability of pregnancy following TAI was higher (odds ratio: 1.74, p < 0.05) in the CIDR group (51.1%) than in the control group (39.3%). Overall, CIDR insert treatment at days 3.5 to 18 increased pregnancy rates relative to non-treated controls, whereas a single GnRH administration on day 5 did not affect the pregnancy outcomes of dairy cows.

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“…Injectable, single-dose long-acting P4 drugs are an alternative to P4 supplementation. Administration of GnRH, hCG or used CIDR resulted in increased pregnancy per artificial insemination in repeat breeder dairy cows (Khoramian et al, 2011).…”

mentioning

confidence: 98%

Effect of Different Hormonal Therapies on Day 5 of Estrus on Plasma Progesterone Profile and Conception Rates in Repeat Breeding Dairy Cows

Kumar¹,

Purohit²

2017

J. Anim. Health Prod.

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| The effect of treatment with a gonadotrophin-releasing hormone (GnRH) analogue-Buserelin acetate, human chorionic gonadotrophin (hCG) and exogenous hydroxy-progesterone caproate on plasma progesterone profile and conception rates was investigated in 44 repeat breeding dairy cattle. Repeat breeding dairy cows on Day 5 post artificial insemination were randomly assigned to four groups: control (no treatment, n=11), Inj GnRH analogue (buserelin acetate, 20µg, n=11), Inj hCG (3000 IU, n=11), or Inj hydroxy progesterone caproate (500 mg, n=11) administered once IM. Progesterone concentration (ng/ml) was determined in plasma of cows on Day 0, 5, 12 and 19, and pregnancy diagnosis was undertaken on Day 60 by rectal palpation. The plasma progesterone concentrations on the Day of insemination were not significantly different between the treatment groups. The plasma progesterone concentration increased significantly (P<0.01) on Day 5 in all cows in all groups. On Day 5 the differences between different treatment groups were non significant. The plasma progesterone concentrations one week after treatment i.e. on Day 12 were significantly higher compared to values on Day 5 in treatment GnRH and treatment hCG (P<0.01). In progesterone treatment and untreated control cows although the plasma progesterone concentrations increased from 2.12±0.25 ng/ml on Day 5 to 4.99±0.23 ng/ml on Day 12 in progesterone treatment and 2.02±0.08 ng/ml on Day 5 to 4.24±0.23 ng/ml on Day 12 in control cows, the differences were non significant. GnRH and hCG treatments increased the plasma progesterone and this probably supported the higher conception rates in these groups. On Day 19 the plasma progesterone concentrations were significantly higher (P<0.01) in all groups compared to progesterone profile on Day 0 and significantly higher (P<0.01) compared to concentrations on Day 5 in GnRH and hCG treatments. When compared to concentrations on Day 12 the progesterone concentration decreased significantly (P<0.01) in hCG treated cows on day 19. Transrectal palpation after treatment in treated cows revealed the formation of accessory corpus luteum in 27.27% cows in GnRH treated, 0% in progesterone treated, and 36.36% in hCG treated cows. The pregnancy rates were highest in hCG treatment (45.45%) followed by GnRH (36.36%) and progesterone (27.27%) compared to untreated control cows (18.18%). It was concluded that the hormonal therapies on Day 5 post insemination increase the plasma progesterone concentration and conception rates in repeat breeding dairy cattle with hCG treatment being the best.

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Comparison of the effects of gonadotropin-releasing hormone, human chorionic gonadotropin or progesterone on pregnancy per artificial insemination in repeat-breeder dairy cows

Cited by 23 publications

References 37 publications

Factors Affecting Pregnancy Rates After Ovum Pick Up-Derived Embryo Transfer in Lactating Holstein Recipients Under Tropical Conditions

Factors Affecting Pregnancy Rates After Ovum Pick Up-Derived Embryo Transfer in Lactating Holstein Recipients Under Tropical Conditions

Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

Effect of Different Hormonal Therapies on Day 5 of Estrus on Plasma Progesterone Profile and Conception Rates in Repeat Breeding Dairy Cows

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