Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study

Yozova, Ivayla D.; Howard, Judith; Henke, Diana; Dirkmann, Daniel; Adamik, Katja‐Nicole

doi:10.1186/s12917-017-1108-2

Cited by 16 publications

(26 citation statements)

References 39 publications

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“…39,40 However, recent clinical studies in dogs do not report a hypocoagulable effect on ROTEM parameters after a single bolus of 7.2% hypertonic saline. 41 Fluid administration may further lead to dilutional coagulopathy. 42,43 When excluding all cats with fluid treatment prior to blood sampling, the incidence of ATC would be only slightly lower with 14% and would not change the occurrence of hypercoagulability after 24 hours.…”

Section: Discussionmentioning

confidence: 99%

Serial Evaluation of Haemostasis Following Acute Trauma Using Rotational Thromboelastometry in Cats

Muri

Schefer

Sigrist

2019

Vet Comp Orthop Traumatol

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Objective The aim of this study was to describe coagulation abnormalities and incidence of acute traumatic coagulopathy (ATC) in traumatized cats over the first 24 hours after admission. Study Design This was a prospective observational study at the university teaching hospital including 26 cats with acute (<5 hours) trauma. Blood was sampled for rotational thromboelastometry (ROTEM) parameters at presentation and 6 hours/24 hours thereafter. Rotational thromboelastometry tracings were defined as hypo- or hypercoagulable if ≥ 2 of the following parameters were above or below institutional reference intervals: clotting time, clot formation time (CFT), maximum clot firmness, maximum lysis or maximum clot elasticity. Hypocoagulability at presentation was defined as ATC. Injury severity scores, treatment and survival to hospital discharge were retrieved from patient records. Results The incidence of ATC was 15% and the most common ROTEM abnormalities in cats with ATC were clotting time and CFT prolongation in both extrinsic and intrinsic ROTEM profiles. After 24 hours, compared with presentation, significantly more cats were hypercoagulable (p = 0.047) and none of the cats showed hypocoagulopathy. Cats with ATC received significantly more blood transfusions (p = 0.008). Conclusion The incidence of ATC in cats is higher than previously reported. Clotting time and CFT prolongations seem to be more common than hyperfibrinolysis and 53% of the cats became hypercoagulable within 24 hours. While the clinical relevance of ATC in cats needs to be investigated, cats diagnosed with ATC required significantly more blood transfusions.

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Section: Discussionmentioning

confidence: 99%

Serial Evaluation of Haemostasis Following Acute Trauma Using Rotational Thromboelastometry in Cats

Muri

Schefer

Sigrist

2019

Vet Comp Orthop Traumatol

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“…, Yozova et al . ). In summary, there are still insufficient data to conclude whether various intravenous fluids will cause clinically significant abnormalities in platelet function.…”

Section: Abnormalities Of Platelet Function Resulting In Haemorrhagementioning

confidence: 97%

“…In a feline study, HES reduced coagulation to a greater degree than a balanced crystalloid solution alone, but platelet function was not assessed specifically (Albrecht et al 2016). Mannitol has also been shown to impair platelet aggregation but not at clinically relevant dilutions (Adamik et al 2015, Yozova et al 2017. In summary, there are still insufficient data to conclude whether various intravenous fluids will cause clinically significant abnormalities in platelet function.…”

Section: Monoclonal Gammopathymentioning

confidence: 99%

Abnormal platelet activity in dogs and cats – impact and measurement

Gant

McBride

Humm

2020

J of Small Animal Practice

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Abnormal platelet activity can either lead to bleeding tendencies or inappropriate thrombus formation and can occur secondarily to a wide variety of disease processes, with a range of clinical consequences and severity. This article will discuss the pathophysiology of platelet function abnormalities and consider a logical diagnostic approach applicable to veterinary practice. Recent advances in platelet function testing will then be discussed, with regards to detection of platelet dysfunction and tailoring of pharmacological manipulation. Although many of these tests are still confined to research or academic institutions, techniques for indirectly assessing platelet function are starting to become more widely available. Although we still require further research to develop guidelines for the use of these tests in clinical decision‐making, the recent advances in this field are an exciting step forward in being able to detect and manage platelet dysfunction in both primary care and referral practice.

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“…HTS is also a first-line treatment option for reduction of intracranial pressure in the management of traumatic brain injuries (TBI), inflammatory CNS disease or intracranial neoplasia (Mangat et al 2015, Carney et al 2017. The other common treatment option in these cases is mannitol (Yozova et al 2017a), stocked by 43.0% of practices. It remains unclear which of these two are superior in the treatment of TBI (Boone et al 2015), however, it would make sense that in patients with both TBI and hypovolaemia, HTS may be more appropriate when hypernatraemia is not an immediate concern.…”

Section: Resultsmentioning

confidence: 99%

Current fluid and blood product availability in veterinary setting: a survey of UK small animal practices

Beeston

Charnock

Cook

2020

J of Small Animal Practice

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Objectives To investigate and discuss current fluid and blood products stocked in small animal practices in the UK. Methods An online survey was circulated to small animal veterinary practices across the UK. The survey included questions regarding the level of hospital care provided, the type of fluid and blood component products stocked, the most frequently restocked products, and the available options in the event that blood products were required but not stocked. Results There were 423 responses including 27 duplicates. The remaining 396 respondents represented a spectrum of practices including 19 referral practices. Crystalloids were stocked in all practices. Lactated Ringer's solution was the most frequently re‐stocked product in 355 of 396 (90%) of practices. Where synthetic colloids were stocked, gelatin‐based colloids (155/178 [87%]) were stocked in preference to hydroxyethyl starches (23/178 [13%]). Blood products were stocked by 81 of 396 (20%) of practices. If a blood product was required but not stocked, 31% of practices would use a pet blood banking service, 28% would use their own blood donors, and 21% would refer. Clinical Significance This study provides an insight into the fluid and blood products stocked and used by a selection of veterinary practices within the UK and serves as a baseline for ongoing research and decision‐making in both veterinary practice and industry.

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Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study

Cited by 16 publications

References 39 publications

Serial Evaluation of Haemostasis Following Acute Trauma Using Rotational Thromboelastometry in Cats

Serial Evaluation of Haemostasis Following Acute Trauma Using Rotational Thromboelastometry in Cats

Abnormal platelet activity in dogs and cats – impact and measurement

Current fluid and blood product availability in veterinary setting: a survey of UK small animal practices

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