Comparison of the effects of dendrimer, micelle and silver nanoparticles on phospholipase A2 structure

Terehova, Maria; Dzmitruk, Volha; Abashkin, Viktar; Kirakosyan, Gayane; Ghukasyan, Gevorg; Bryszewska, Maria; Pedziwiatr-Werbicka, Elzbieta; Йонов, Максим; Gómez, Rafael; Mata, F. Javier de la; Mignani, Serge; Shi, Xiangyang; Majoral, Jean‐Pierre; Sukhodola, A. A.; Shcharbin, Dzmitry

doi:10.1016/j.jbiotec.2021.03.009

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…Meanwhile, the high degree of branching also allows it to have a special role in the cell membrane. [87,88] For advanced dendrimers, the core is equivalent to a microenvironment surrounded by branches, which is not affected by the external environment, so the interior is very suitable for encapsulating guest molecules.…”

Section: Structure Of Dendrimermentioning

confidence: 99%

Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Wang,

Zhang,

et al. 2023

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Dendrimers are a family of polymers with highly branched structure, well‐defined composition, and extensive functional groups, which have attracted great attention in biomedical applications. Micelles formed by dendrimers are ideal nanocarriers for delivering anticancer agents due to the explicit study of their characteristics of particle size, charge, and biological properties such as toxicity, blood circulation time, biodistribution, and cellular internalization. Here, the classification, preparation, and structure of dendrimer micelles are reviewed, and the specific functional groups modified on the surface of dendrimers for tumor active targeting, stimuli‐responsive drug release, reduced toxicity, and prolonged blood circulation time are discussed. In addition, their applications are summarized as various platforms for biomedical applications related to cancer therapy including drug delivery, gene transfection, nano‐contrast for imaging, and combined therapy. Other applications such as tissue engineering and biosensor are also involved. Finally, the possible challenges and perspectives of dendrimer micelles for their further applications are discussed.

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Section: Structure Of Dendrimermentioning

confidence: 99%

Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Wang,

Zhang,

et al. 2023

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“…The complex formed between these systems was hidden better from serum proteins, becoming more active against E. coli than the complex formed between AgNP covered only with CBS dendrons and lysozyme (Ciepluch et al, 2020). That is, the presence of PEG in these AgNP reduces the formation of protein corona (Terehova et al, 2021).…”

Section: Treatment and Diagnosis Of Bacterial Infectionsmentioning

confidence: 99%

“…coli than the complex formed between AgNP covered only with CBS dendrons and lysozyme (Ciepluch et al, 2020). That is, the presence of PEG in these AgNP reduces the formation of protein corona (Terehova et al, 2021).…”

Section: Pharmaceutical Applications Of Carbosilane Dendritic Moleculesmentioning

confidence: 99%

Carbosilane dendritic nanostructures, highly versatile platforms for pharmaceutical applications

Mata

Gomez-Ramirez

Cano

et al. 2022

WIREs Nanomed Nanobiotechnol

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Dendrimers are multifunctional molecules with well‐defined size and structure due to the step‐by‐step synthetic procedures required in their preparation. Dendritic constructs based on carbosilane scaffolds present carbon–carbon and carbon–silicon bonds, which results in stable, lipophilic, inert, and flexible structures. These properties are highly appreciated in different areas, including the pharmaceutical field, as they can increase the interaction with cell membranes and improve the therapeutic action. This article summarizes the most recent advances in the pharmaceutical applications of carbosilane dendritic molecules, from therapeutics to diagnostics and prevention tools. Dendrimers decorated with cationic, anionic, or other moieties, including metallodendrimers; supramolecular assemblies; dendronized nanoparticles and surfaces; as well as dendritic networks like hydrogels are described. The collected examples confirm the potential of carbosilane dendrimers and dendritic materials as antiviral or antibacterial agents; in therapy against cancer, neurodegenerative disease, or oxidative stress; or many other biomedical applications. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…В лаборатории нанобиотехнологий Института биофизики и клеточной инженерии НАН Беларуси в настоящее время ведутся работы по изучению возможности применения амфифильных дендронов, синтезированных группой профессора Мажораля, в качестве векторов для переноса малых РНК в клетки. Исследуется также цитотоксичность этих структур и их взаимодействие с белками, нуклеиновыми кислотами и клетками [55].…”

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Interaction of polyamidoamine dendrimers and amphiphylic dendrons with lipid membranes

Terehova

Abashkin

Zhogla

et al. 2021

Vescì Akademìì navuk Belarusì. Seryâ biâlagičnyh navuk

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Polyamidoamine (PAMAM) dendrimers and amphiphilic dendrons are one of the types of nanomaterials characterized by a hyperbranched structure of polymer branches. In the case of dendrimers, the dendrons are covalently linked at the central focal point. In the case of amphiphilic dendrons, dendrons are non-covalently linked by hydrophobic interactions, forming micellar structures. These nanoparticles are widely used in biology and medicine as contrast agents, carriers of drugs and genetic material. Their use in scientific practice requires an understanding of the basic mechanisms of their interaction with membranes – the main obstacle to the entry of dendrimers into the cell. This review discusses the regularities of the interaction of dendrimers and amphiphilic dendrons with lipid membranes. Various models of dendrimer-membrane interactions are described as the basis for the penetration of dendrimers and amphiphilic nanoparticles into cells. Keywords: polyamidoamine dendrimers, amphiphilic dendrons, lipid membranes, cells, antitumor therapeutics, antibacterial agents, diagnostics, genetic therapy.

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Comparison of the effects of dendrimer, micelle and silver nanoparticles on phospholipase A2 structure

Cited by 3 publications

References 33 publications

Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Carbosilane dendritic nanostructures, highly versatile platforms for pharmaceutical applications

Interaction of polyamidoamine dendrimers and amphiphylic dendrons with lipid membranes

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