Comparison of the effects of preservation methods on structural, biological, and mechanical properties of the human amniotic membrane for medical applications

Jafari, Ameneh; Mirzaei, Yousef; Mer, Ali Hussein; Rezaei-Tavirani, Mostafa; Jafari, Zahra; Niknejad, Hassan

doi:10.1007/s10561-023-10114-z

Cell Tissue Bank

2023

DOI: 10.1007/s10561-023-10114-z

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Comparison of the effects of preservation methods on structural, biological, and mechanical properties of the human amniotic membrane for medical applications

Ameneh Jafari,

Yousef Mirzaei,

Ali Hussein Mer

et al.

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2024

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Cited by 2 publications

References 118 publications

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Characterization of Amnion-Derived Membrane for Clinical Wound Applications

Ingraldi,

Allen,

Tinghitella

et al. 2024

Bioengineering

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Human amniotic membrane (hAM), the innermost placental layer, has unique properties that allow for a multitude of clinical applications. It is a common misconception that birth-derived tissue products, such as dual-layered dehydrated amnion–amnion graft (dHAAM), are similar regardless of the manufacturing steps. A commercial dHAAM product, Axolotl Biologix DualGraft™, was assessed for biological and mechanical characteristics. Testing of dHAAM included antimicrobial, cellular biocompatibility, proteomics analysis, suture strength, and tensile, shear, and compressive modulus testing. Results demonstrated that the membrane can be a scaffold for fibroblast growth (cellular biocompatibility), containing an average total of 7678 unique proteins, 82,296 peptides, and 96,808 peptide ion variants that may be antimicrobial. Suture strength results showed an average pull force of 0.2 N per dHAAM sample (equating to a pull strength of 8.5 MPa). Tensile modulus data revealed variation, with wet samples showing 5× lower stiffness than dry samples. The compressive modulus and shear modulus displayed differences between donors (lots). This study emphasizes the need for standardized processing protocols to ensure consistency across dHAAM products and future research to explore comparative analysis with other amniotic membrane products. These findings provide baseline data supporting the potential of amniotic membranes in clinical applications.

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Characterization of Amnion-Derived Membrane for Clinical Wound Applications

Ingraldi,

Allen,

Tinghitella

et al. 2024

Bioengineering

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Application of Fetal Membranes and Natural Materials for Wound and Tissue Repair

Rouzaire,

Blanchon,

Sapin

et al. 2024

IJMS

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The human fetal membrane is a globally accepted biological biomaterial for wound and tissue repair and regeneration in numerous fields, including dermatology, ophthalmology, and more recently orthopedics, maxillofacial and oral surgery, and nerve regeneration. Both cells and matrix components of amnion and chorion are beneficial, releasing a diverse range of growth factors, cytokines, peptides, and soluble extracellular matrix components. Beside fetal membranes, numerous natural materials have also been reported to promote wound healing. The biological properties of these materials may potentiate the pro-healing action of fetal membranes. Comparison of such materials with fetal membranes has been scant, and their combined use with fetal membranes has been underexplored. This review presents an up-to-date overview of (i) clinical applications of human fetal membranes in wound healing and tissue regeneration; (ii) studies comparing human fetal membranes with natural materials for promoting wound healing; and (iii) the literature on the combined use of fetal membranes and natural pro-healing materials.

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Comparison of the effects of preservation methods on structural, biological, and mechanical properties of the human amniotic membrane for medical applications

Cited by 2 publications

References 118 publications

Characterization of Amnion-Derived Membrane for Clinical Wound Applications

Characterization of Amnion-Derived Membrane for Clinical Wound Applications

Application of Fetal Membranes and Natural Materials for Wound and Tissue Repair

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