Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans.

Hussain, Mehboob A.; Schmitz, O.; Mengel, A.; Glatz, Y; Christiansen, Jens Sandahl; Zapf, J.; Froesch, E. R.

doi:10.1172/jci117427

Cited by 121 publications

(83 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These changes included reduced circulating levels of leucine and leucine oxidation and the increased leucine MCR and net leucine balance. Similar findings have been observed after IGF-I administration in healthy subjects and GH-deficient adults (32)(33)(34)(35) and in patients with Cushing's syndrome after GH therapy (36). Evidence suggests that GH therapy results in upregulation of amino acid transporter systems (37), increasing the efficiency of cellular amino acid uptake.…”

Section: Discussionsupporting

confidence: 64%

“…It is likely that decreased GH-mediated lipolysis and simultaneously enhanced insulin sensitivity resulted in the lower circulating NEFA levels during the IGF-I administration. A study of IGF-I administration in GH-deficient adults also demonstrated reductions in NEFA levels (33), indicating that IGF-I may also regulate NEFA levels through mechanisms independent of GH.…”

mentioning

confidence: 99%

See 1 more Smart Citation

IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.

et al. 2000

View full text Add to dashboard Cite

Type 1 diabetes is associated with abnormalities of the growth hormone (GH)-IGF-I axis. Such abnormalities include decreased circulating levels of IGF-I. We studied the effects of IGF-I therapy (40 µg · kg -1 · day -1 ) on protein and glucose metabolism in adults with type 1 diabetes in a randomized placebo-controlled trial. A total of 12 subjects participated, and each subject was studied at baseline and after 7 days of treatment, both in the fasting state and during a hyperinsulinemiceuglycemic amino acid clamp. Protein and glucose metabolism were assessed using infusions of [1- 13C]leucine and [6-6-2 H 2 ]glucose. IGF-I administration resulted in a 51% rise in circulating IGF-I levels (P < 0.005) and a 56% decrease in the mean overnight GH concentration (P < 0.05). After IGF-I treatment, a decrease in the overnight insulin requirement (0.26 ± 0.07 vs. 0.17 ± 0.06 U/kg, P < 0.05) and an increase in the glucose infusion requirement were observed during the hyperinsulinemic clamp (~67%, P < 0.05). Basal glucose kinetics were unchanged, but an increase in insulin-stimulated peripheral glucose disposal was observed after IGF-I therapy (37 ± 6 vs. 52 ± 10 µmol · kg -1 · min -1 , P < 0.05). IGF-I administration increased the basal metabolic clearance rate for leucine (~28%, P < 0.05) and resulted in a net increase in leucine balance, both in the basal state and during the hyperinsulinemic amino acid clamp (-0.17 ± 0.03 vs. -0.10 ± 0.02, P < 0.01, and 0.25 ± 0.08 vs. 0.40 ± 0.06, P < 0.05, respectively). No changes in these variables were recorded in the subjects after administration of placebo. These findings demonstrated that IGF-I replacement resulted in significant alterations in glucose and protein metabolism in the basal and insulinstimulated states. These effects were associated with increased insulin sensitivity, and they underline the major role of IGF-I in protein and glucose metabolism in type 1 diabetes. Diabetes 49:789-796, 2000 I GF-I shares a 40% sequence homology with human proinsulin and exhibits both insulin-like and anabolic effects (1,2). The availability of recombinant human IGF-I (rhIGF-I) has led to interest in the potential of this peptide in the treatment of a variety of disease states (3-7). Type 1 diabetes has received particular attention, because the relative portal insulin deficiency of this condition is thought to be responsible for the reduced circulating levels of IGF-I (8), which in turn, through decreased negative feedback, leads to increased secretion of growth hormone (GH) (9).Recent studies have demonstrated improved glycemic control in patients with types 1 and 2 diabetes after IGF-I treatment (10,11). IGF-I administration has also been shown to reduce the GH hypersecretion of adolescents and adults with type 1 diabetes (12,13). In those studies, the reductions in GH secretion were associated with decreased insulin requirements, without alteration in glycemic control, which indicates an increase in insulin sensitivity.In addition to disordered glucose metabolism, patients with t...

show abstract

Section: Discussionsupporting

confidence: 64%

mentioning

confidence: 99%

IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Each value is the mean ± standard error of the mean. GH is thought to increase the basal metabolic rate through thermogenesis [14] and the induction of catecholamine release [28], increasing the conversion of the thyroid hormone T4 to the more metabolically active T3 [29], and increasing IGF-1 secretion, which may participate in increasing resting energy expenditure [30]. Conversely, adult KK-A y mice with markedly elevated IGF-1 levels showed decreased UCP1 and UCP3 expressions.…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone Administration Controls Body Composition Associated with Changes of Thermogenesis in Obese KK-Ay Mice~!2009-08-29~!2010-01-12~!2010-03-26~!

Hioki¹,

Yoshida²,

Kogure³

et al. 2010

TOEJ

View full text Add to dashboard Cite

Abstract:We investigate the effects of continuous human growth hormone (GH) therapy in young obese mice on thermogenesis. Female KK-A y obese mice (n=10) were injected subcutaneously with GH (3.5 mg/kg/day) for 30 days from 42 days old. As a control, physiological saline was administered (n=10). At the terminal point (71 days old), GH administration affected linear growth, and the Lee obesity index (3 square root body weight/nasoanal length 1000) was significantly decreased. Rates of inguinal and perimetric white adipose pads per body weight also decreased. Free fatty acid levels decreased, while plasma insulin concentrations and homeostasis model assessment insulin resistance were increased (P<0.01). Plasma insulin-like growth factor (IGF-1) levels markedly rose (P<0.00001). Uncoupling protein1 (UCP1) and UCP3 mRNA expressions in brown adipose tissue were inhibited (P<0.05). Continuous GH therapy changed obese body composition toward lean, however, the consequence could be the negative regulation of thermogenesis.

show abstract

“…The mean energy intake of the individuals in our study (E6213 kJ) was below that reported in a population-based study comprising the whole Brazilian population (EN-DEF ¼ National Study of Family Expenditure), a study carried out in 1974/1975, and in which the mean energy consumption was 8493 kJ (Fundação IBGE, 1977). More recently, another population-based study (Hussain et al, 1994) found even higher numbers (10 878 kJ). Obesity, stunting and food pattern T T Florêncio et al…”

Section: Stature and Energy Consumptionmentioning

confidence: 92%

“…For instance, the lower concentration of the insulin-like growth factor I (IGF-I) is accompanied by a lower sensitivity of the hormone sensitive lipase to the lipolytic hormones. For this reason, any reduction in IGF-I may result in lower fat oxidation (Hussain et al, 1994).…”

Section: Stature and Energy Consumptionmentioning

confidence: 99%

Food consumed does not account for the higher prevalence of obesity among stunted adults in a very-low-income population in the Northeast of Brazil (Maceió, Alagoas)

et al. 2003

View full text Add to dashboard Cite

Objective: To study the food pattern of stunted and nonstunted, obese and nonobese individuals in a very-low-income population. Design: A household survey. Setting: Slum set up by the 'Homeless Movement', city of Maceió (Alagoas), Brazil. Subjects and methods: A total of 532 adults classified by sex, stature (Zr and Z 4 À2s.d. of the NCHS curves), and body mass index (BMI) were compared using the following variables: waist circumference, waist-hip circumference ratio (W/H), percentage body fat (skinfold thickness and bioelectrical impedance), and food intake (24-h recall). Results: The prevalence of stunting was 22.6%. In all, 30% of the stunted subjects were overweight or obese, compared with 23% for the nonstunted individuals (Po0.05). In women, logistic regression analysis showed a strong association among weight, abdominal fat, and stunting (r ¼ 0.81). No significant differences were observed in the values of W/H or in the qualitative menu of the different categories. Energy intake was below the RDA figures (about 63%). There was similarity among the groups regarding the proportion of macronutrients, except for the fact that stunted obese women ingested less fat and protein than nonstunted obese women. Stunted obese individuals consumed less energy (5962 kJ) than the population as a whole (6213 kJ), an amount far lower than their average needs, which were calculated on the basis of their shorter stature (8109 kJ). Conclusion: The observed energy consumption seems compatible with the panorama of undernutrition present in the population, but it does not explain the high prevalence of obesity detected.

show abstract

Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans.

Cited by 121 publications

References 39 publications

IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.

IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.

Growth Hormone Administration Controls Body Composition Associated with Changes of Thermogenesis in Obese KK-Ay Mice~!2009-08-29~!2010-01-12~!2010-03-26~!

Food consumed does not account for the higher prevalence of obesity among stunted adults in a very-low-income population in the Northeast of Brazil (Maceió, Alagoas)

Contact Info

Product

Resources

About