Comparison of the Effects of Moist and Dry Conditions on Dermal Repair

Dyson, Mary; Young, Steve; Pendle, C Len; Webster, David; Lang, Simone

doi:10.1111/1523-1747.ep12476467

Cited by 205 publications

(93 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moisture on wounds accelerates the epithelialization phase of wound healing by preventing scab formation over the wound bed. This increases migration of proliferative cells, such as fibroblast and endothelial cells that produces angiogenesis and promotes growth factors and keratinocytes, which results in faster dermal repair and reduced scarring of the wound [5] [6] [7]. Additionally, it has been shown that moist wounds decrease bacterial infection by the formation of a hostile antibacterial environment [8].…”

Section: Introductionmentioning

confidence: 99%

Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment

Gómez

Morgan

Hayes-Gill

et al. 2018

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

The sensitivity of a low-cost polymeric optical fibre humidity sensor based on transmittance changes due to evanescent wave absorption is reported using test measurements in an environmental chamber and of the skin. The layer-by-layer method was used to coat 30mm of the central unclad section of a multimode polymeric optical fibre with 7 layers of a hydrophilic film consisting of bilayers of poly(allylamine hydrochloride) and SiO2 mesoporous nanoparticles. Sensor characterisation shows a decrease in light transmission as relative humidity increases as a result of refractive index changes of the coating deposited onto the optical fibre which correlates with a commercial capacitive humidity sensor. The sensitivity obtained for the sensor coated with an optimum 7 layers was approximately -3.87x10 -3 and -9.61x10 -3 in transmittance percentage per RH percentage for the range of ~10% to ~75% RH and 90% to 97% RH, respectively. In addition, a response time of 1.5s can be seen for breath monitoring with the polymeric optical fibre humidity sensor. The proof of concept measurements made on the skin indicate that this sensor has the potential to be used to monitor humidity of the skin microenvironment within a wound dressing which can be used to provide better prognosis of healing.

show abstract

Section: Introductionmentioning

confidence: 99%

Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment

Gómez

Morgan

Hayes-Gill

et al. 2018

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4] There are two kinds of dressings: dry type and wet type. It has been reported that healing with a wet environment is faster than that with a dry environment.…”

mentioning

confidence: 99%

Development of Clindamycin-Loaded Wound Dressing with Polyvinyl Alcohol and Sodium Alginate

Kim

Choi

Park

et al. 2008

Biological & Pharmaceutical Bulletin

104

View full text Add to dashboard Cite

To develop a clindamycin-loaded wound dressing, cross-linked hydrogel films were prepared using freezethawing method with various mixtures of polyvinyl alcohol (PVA) and sodium alginate (SA). The physicochemical properties such as swelling ratio, tensile strength and elongation of hydrogels were evaluated. The drug release from this clindamycin-loaded hydrogel, in vitro protein adsorption test and in vivo wound healing observations in rats were then performed. Increased SA concentration decreased the gelation %, maximum strength and break elongation, but it resulted into an increment in the swelling ability, elasticity and thermal stability of hydrogel film. However, SA had insignificant effect on the release of clindamycin. This hydrogel improved the healing rate of artificial wounds in rats. Thus, a clindamycin-loaded wound dressing with PVA and SA hydrogel should be a candidate for wound care.

show abstract

“…Moreover, the maintenance of an aqueous medium in the wound is a determining factor in the evolution of healing. 2,6 Brown et al reported a reduction in wound retraction in cutaneous grafts applied with fibrin glue. 13 In this study, the reduction in retraction of grafted wounds was attributed to the graft itself, because the evolution of healing was similar to that of the control group.…”

Section: Second Intention Healingmentioning

confidence: 99%

“…1 The first experiments in the use of fibrinogen as a tissue adhesive were carried out in 1940. 2 The concept of fibrin glue became realistic in the 1970's, with the advent of techniques for isolation and concentration of coagulation factors. In 1972, the success of fibrin glue in repairing a peripheral nerve was described.…”

Section: Introductionmentioning

confidence: 99%

Use of autologous fibrin glue in dermatologic surgery: application of skin graft and second intention healing

1998

View full text Add to dashboard Cite

Objective:To evaluate the efficiency of biological sealant, an autologous fibrin glue, in dermatological surgery. Design: Randomized clinical trial. Setting: The Dermatology Service of Hospital das Clínicas, Universidade de Campinas (UNICAMP), referral center. Patients: 14 patients with malign epithelial cutaneoos tumors participated in the evaluation, each having two tumors, generally facial and symmetrical, in order to perform a comparative evaluation on the same individual. Procedures: The glue was prepared beforehand with a sample of autologous blood. Surgical extirpation of the tumor was followed by grafts or second intention healing. Outcomes: The efficiency of the sealant was then evaluated in relation to hemostasis, adhesion, surgical time and evolution of the granulation tissue, clinically and histologically. Results: Immediate hemostasis and graft adhesion, with a significant reduction of surgical time, and in the open wounds there was immediate hemostasis and a clinical increase in granulation tissue, but with no histological differences among the groups on the 7 th day. Conclusion: It is an adjuvant resource in skin cancer surgery.Uniterms: Fibrin glue. Wound healing. Skin cancer. Dermatologic surgery.

show abstract

Comparison of the Effects of Moist and Dry Conditions on Dermal Repair

Cited by 205 publications

References 8 publications

Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment

Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment

Development of Clindamycin-Loaded Wound Dressing with Polyvinyl Alcohol and Sodium Alginate

Use of autologous fibrin glue in dermatologic surgery: application of skin graft and second intention healing

Contact Info

Product

Resources

About