Comparison of the Effects of Septoplasty and Sinus Lifting Simulation in Rats on Changes in Heart Rate Variability

Драгунова, С. Г.; Reshetov, Igor V.; Косырева, Т. Ф.; Северин, А. Е.; Khamidulin, G. V.; Shmaevsky, P. E.; Иноземцев, А. Н.; Popadyuk, V. I.; Кастыро, И. В.; Yudin, D. K.; Yunusov, T. Yu.; Kleyman, V.K.; Bagdasaryan, V. V.; Alieva, S. I.; Chudov, R. V.; Kuznetsov, N. D.; Pinigina, I. V.; Skopich, A. A.; Kostyaeva, M. G.

doi:10.1134/s1607672921030029

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…Morphological changes in the hippocamp are confirmed by our previous studies, which showed that septoplasty simulation in rats provokes the development of many stress reactions [34] and even a breakdown in adaptation [35]: an increase in the number of dark neurons [36], the expression of the p53 protein [3], a significant release of corticosterone into the blood plasma [37], and an increase in degranulation of mast cells [38], disturbances in the balance of the autonomic nervous system [39,40], changes in behavior when testing rats in an open field [9], the appearance of anxiety and a depressivelike state [41].…”

Section: Discussionsupporting

confidence: 61%

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Role of Septoplasty as a Stressor in P53 and Dark Neurons Formation During Septoplasty Simulation in Rats

Кастыро¹,

Mikhalskaia²,

Khamidulin³

et al. 2022

ArveMED

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The aim of this study was to determine the role of surgical stress on the formation of p53-positive and dark neurons (DN) in the hippocampus, and to examine the parallelism of their formation in the pyramidal layer of the hippocampus. Simulated septoplasty was performed on 20 Wistar rats. The hippocampus and dentate gyrus (DG) were examined, in which the number of DN and p53-positive neurons was determined at 2, 4 and 6 days after surgery. Compared with the control group (n = 5), the number of DN and p53-positive neurons increased in experimental animals at all periods. A direct relationship was obtained between the increase in the number of DN and p53-positive neurons in the hippocampal formation. Septoplasty simulation in rats results in the pathogenetic cascades onset, which, in its turn, changes the morpho-functional properties of neurons of the pyramidal layer of the hippocampus and contributes to their neuroplasticity. Activation of NMDS receptors of neurons during stress, apparently, initiates two ways of neuron life – the beginning of p53 protein expression and the DN formation. Both ways can finally lead to apoptosis. The formation of dark neurons and the expression of the p53 protein in them are most likely to be interconnected and can probably provide neuroprotective mechanisms.

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Section: Discussionsupporting

confidence: 61%

“…Simulated septoplasty in rats leads to the development of a powerful stress response. Few experimental data are available to determine the consequences of nasal surgery [1].…”

Section: Introductionmentioning

confidence: 99%

Role of Septoplasty as a Stressor in P53 and Dark Neurons Formation During Septoplasty Simulation in Rats

Кастыро¹,

Mikhalskaia²,

Khamidulin³

et al. 2022

ArveMED

View full text Add to dashboard Cite

show abstract

“…Morphological changes in the hippocamp are confirmed by our previous studies, which showed that septoplasty simulation in rats provokes the development of many stress reactions [34] and even a breakdown in adaptation [35]: an increase in the number of dark neurons [36], the expression of the p53 protein [3], a significant release of corticosterone into the blood plasma [37], and an increase in degranulation of mast cells [38], disturbances in the balance of the autonomic nervous system [37,39,40], changes in behavior when testing rats in an open field [9], the appearance of anxiety and a depressive-like state [37,[41][42][43].…”

Section: Discussionsupporting

confidence: 61%

Expression of the P53 Protein and Morphological Changes in Neurons in the Pyramidal Layer of the Hippocampus After Simulation of Surgical Interventions in the Nasal Cavity in Rats

Кастыро

Mikhalskaia

Khamidulin

et al. 2023

Cell Physiol Biochem

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Background/Aims: to determine the role of surgical stress on the formation of p53-positive and dark neurons (DN) in the hippocampus, and to examine the parallelism of their formation in the pyramidal layer of the hippocampus. Methods: Simulated septoplasty was performed on 20 Wistar rats. The hippocampus and dentate gyrus (DG) were examined, in which the number of DN and p53-positive neurons was determined at 2, 4 and 6 days after surgery. In each rat, 10 brain slices were stained with antibodies to p53 protein with Meyer’s haematoxylin and 10 slices were stained with Nissl toluidine blue. Hippocampal subfields CA1, CA2, CA3 and DG were studied. In the pyramidal subfield layer, the absolute number of neurons that were nuclear antibody-positive to p53 protein was counted, as well as the number of dark neurons. The counting area in each subfield was 20934±1260 µm2. Neurons are counted using the Aperio ImageScope program. For the histological specimen analysis, the ImageJ software was used. The data obtained using cell counting methods were presented as mean ± SE. Then, they were compared between both groups using a t-test SPSS 21software. Results: Compared with the control group (n = 5), the number of DN and p53-positive neurons increased in experimental animals at all periods. A direct relationship was obtained between the increase in the number of DN and p53-positive neurons in the hippocampal formation. Septoplasty simulation in rats results in the pathogenetic cascades onset, which, in its turn, changes the morpho-functional properties of neurons of the pyramidal layer of the hippocampus and contributes to their neuroplasticity. Activation of NMDS receptors of neurons during stress apparently, initiates two ways of neuron life – the beginning of p53 protein expression and the DN formation. Both ways can finally lead to apoptosis. Conclusion: The formation of dark neurons and the expression of the p53 protein in them are most likely to be interconnected and can probably provide neuroprotective mechanisms.

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“…A progressive trend in maxillofacial and bone surgery is the possibility of personalizing implantprosthetic structures [ [13][14][15][16] ]. Application of additive technologies for manufacturing individual maxillofacial implants makes it possible to design and prototype complex solutions on models, optimize prosthesis fixation systems taking into account elasticity modulus and bone density.…”

Section: Discussionmentioning

confidence: 99%

“…With significant bony defects of the face and jaws, the soft tissues are deformed and not always sufficient to cover the flap. The possibilities of preliminary volume augmentation and quality of soft tissues in the area of the bone defect are studied [ 4,16 ]. Tissue silicone expanders have been used in oral surgery for quite a long time, but the result is not always stable [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Personal Approach to Implant-Prosthetic Dental Rehabilitation After Autopolitrauma

Put

Usatov

Svyatoslavov

et al. 2023

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With extensive damage of the facial skeleton, multiple bony and soft tissue cicatricial defects and deformations are formed. Traditional methods of reconstructive are reliably not able to restore the defects fully. Often the bony structures of the facial skeleton can't be restored in one stage. Additional reconstructive surgeries are needed. A problematic situation is the condition after multiple surgeries in the defect area. Failure of bone grafting is associated with cicatricial deformities and lack of soft tissue, lack of gingiva, defects in the vestibule and damaged periosteum. The main problem is constriction and subsequent atrophy and deformation of the soft tissue in the area of the defect. This complicates further treatment and often it isn't possible to restore the bone volume required for a successful dental implantation.Implant prosthetic rehabilitation in the area of extensive bone defects after a facial injury requires preparation that is more careful, design and prototyping of the outcome with the use of computer programs and diagnostic models. Biocompatible materials for dentistry and maxillofacial surgery are clinically proven and recommended for usage in patients at the treatment stages. Clinical experience with individual temporary endoprosthesis, so called "tissue expander", produced by layer-by-layer synthesis (3D-printing) from biologically inert plastic based on CT data of the patient is presented in this article. The expander is made in the form of a 3D element to form the required soft tissue volume in the patient for 4-6 months and is fixed in place subcutaneously, in the area of mandibular frontal defect, using intraosseous screws. Dental implants were placed laterally on both sides. The following was carried out intraoperative direct replacement, fabrication and placement in the mouth of a temporary screw-retained prosthesis.

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Comparison of the Effects of Septoplasty and Sinus Lifting Simulation in Rats on Changes in Heart Rate Variability

Cited by 11 publications

References 15 publications

Role of Septoplasty as a Stressor in P53 and Dark Neurons Formation During Septoplasty Simulation in Rats

Role of Septoplasty as a Stressor in P53 and Dark Neurons Formation During Septoplasty Simulation in Rats

Expression of the P53 Protein and Morphological Changes in Neurons in the Pyramidal Layer of the Hippocampus After Simulation of Surgical Interventions in the Nasal Cavity in Rats

A Personal Approach to Implant-Prosthetic Dental Rehabilitation After Autopolitrauma

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