Comparison of the effects of marchantin C and fucoidan on sFlt-1 and angiogenesis in glioma microenvironment

Lv, Yafeng; Song, Qingxu; Shao, Qianqian; Gao, Wenjuan; Mao, Hongzhi; Lou, Hongxiang; Qu, Xun; Li, Xingang

doi:10.1111/j.2042-7158.2011.01430.x

Cited by 23 publications

(17 citation statements)

References 33 publications

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“…Fucoidan was reported to suppress the growth pro-myeloid cancer cells [32], which supports the results of the present study that predicted effects of UPF on chronic and acute myeloid leukemias. Fucoidan has also been shown to affect the growth of glioma cells [30] and inhibit glioma cell-induced angiogenesis [33]. Fucoidans can act as both anti-angiogenic and pro-angiogenic agents, dependent mostly on their molecular weight [27], which was also identified by the present study.…”

Section: Discussionsupporting

confidence: 73%

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

et al. 2020

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Fucoidans are a class of fucose-rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo-controlled double-blind pilot study was performed in healthy volunteers. Blood samples were taken immediately before and 24 h after ingestion of a single dose of 1 g of Undaria pinnatifida fucoidan (UPF) or placebo. Levels of isolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754 miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS data analysis tool predicted 29 different pathways and processes that were largely grouped into cell surface receptor signaling, cancer-related pathways, the majority of which were previously associated with fucoidans. However, this analysis also identified nine pathways and processes that have not been associated with fucoidans before. Overall, this study illustrates that even a single dose of fucoidans has the potential to affect the expression of genes related to fundamental cellular processes. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells, inflammation, and neurological function.

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Section: Discussionsupporting

confidence: 73%

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

et al. 2020

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“…Lv et al reported that fucoidan inhibited both T98G and THP1 cell-induced angiogenesis [32]. Proangiogenic molecules, such as bFGF, VEGF, and IL-8, play important roles in angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Fucoidan, which is a sulphated polysaccharide purified from Sargassum , possesses a variety of anticancer effects, including the inhibition of the growth of HCC Huh7 cells and HepG2 cells, the induction of apoptosis and autophagy of human MCF-7 breast cancer cells, the Lewis lung carcinoma cells, melanoma B16 cells, and AGS human gastric adenocarcinoma cells, and the induction of the functional maturation of human monocyte-derived dendritic cells, T-cells, and natural killer cells [26–31]. Lv et al reported that fucoidan inhibits both T98G and THP1 cell-induced angiogenesis [32]. However, the mechanisms of action through which fucoidan exhibits anticancer activity have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Fucoidan Inhibits the Growth of Hepatocellular Carcinoma Independent of Angiogenesis

Zhu

Cao

Zhang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Some sulphated polysaccharides can bind bFGF but are unable to present bFGF to its high-affinity receptors. Fucoidan, a sulphated polysaccharide purified from brown algae, which has been used as an anticancer drug in traditional Chinese medicine for hundreds of years, exhibits a variety of anticancer effects, including the induction of the apoptosis and autophagy of cancer cells, the inhibition of the growth of cancer cells, the induction of angiogenesis, and the improvement of antitumour immunity. Our research shows that fucoidan dose not inhibit the expressions of VEGF, bFGF, IL-8, and heparanase in HCC cells and/or tumour tissues. Moreover, fucoidan exhibited low affinity for bFGF and could not block the binding of bFGF to heparan sulphated. Although fucoidan had no effect on angiogenesis and apoptosis in vivo, this drug significantly inhibited the tumour growth and the expression of PCNA. These results suggest that fucoidan exhibits an anticancer effect in vivo at least partly through inhibition of the proliferation of HCC cells, although it is unable to suppress the angiogenesis induced by HCC.

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“…The ability of fucoidan to work in synergy with standard anticancer agents has recently been investigated [20]. Fucoidan has shown to affect the migration and invasion of multiple myeloma (MM) cells treated with the chemotherapy drug cytarabine [493]. Human myeloma cell lines RPMI8226 and U266 were treated with crude fucoidan from F. vesiculosus for 72h followed by cytarabine for 6 h. Fucoidan reduced cell migration through a Boyden chamber and downregulated expression of CXCR4 and MMP-9.…”

Section: Fucoidan As a Synergistic Anticancer Agentmentioning

confidence: 99%

Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines

Abudabbus

Badmus

Shalaweh

et al. 2017

CPB

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Fucoidan is an effective antitumor agent, either alone or in combination with cisplatin, doxorubicin and taxol in MCF-7 breast cancer cells. Drug combinations that discriminate between cancerous and non-cancerous cells afford a plausible and viable strategy of attaining therapeutic efficacy and avoiding possible toxicity and side effects. These findings suggest that fucoidan is a promising candidate for cancer combination therapies.

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Comparison of the effects of marchantin C and fucoidan on sFlt-1 and angiogenesis in glioma microenvironment

Abstract: This study suggested for the first time that marchantin C and fucoidan could significantly inhibit angiogenesis induced by glioma cells or monocytes. Up-regulation of sFlt-1 played an important role in this process.

Cited by 23 publications

References 33 publications

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

Fucoidan Inhibits the Growth of Hepatocellular Carcinoma Independent of Angiogenesis

Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines

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