Comparison of the effects of 1,25 dihydroxycholecalciferol and prostaglandin E2 on orthodontic tooth movement

Kale, Selin; Kocadereli, İlken; Atilla, Pergin; Aşan, Esin

doi:10.1016/j.ajodo.2003.06.002

Cited by 146 publications

(121 citation statements)

References 43 publications

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“…In a comparison study, the active form of Vitamin D enhanced tooth movement as much as PGE2, but PGE2 promoted higher number of Howship's lacunae in the compression side (Kale et al, 2004). However, Vitamin D increased the number of osteoblasts in the formation side.…”

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 92%

“…In bone biology, lower dosages of PGE2 were shown to have anabolic effects, whereas higher dosages appear to disrupt this effect and cause bone resorptionthis effect appears to be linked to a consequential increase in IGF-1 levels (Baylink, Finkelman & Mohan, 1993). In orthodontics, there seems to be a consensus on the fact that PGE2 injections increase the rate of tooth movement (Bao, Zhao & Rao, 1995;Chao et al, 1988;Kale et al, 2004;Kokkinos et al, 1993;Leiker et al, 1995;Seifi, Eslami & Saffar, 2003). In contrast to orthopedic studies, which typically show anabolic effects of PGE2 (Norrdin, Jee & High, 1990), studies have reported increase in bone resorption alone (Boekenoogen et al, 1996;Chao et al, 1988;Kale et al, 2004;Leiker et al, 1995;Seifi et al, 2003;Yamasaki, Shibata & Fukuhara, 1982).…”

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

“…In orthodontics, there seems to be a consensus on the fact that PGE2 injections increase the rate of tooth movement (Bao, Zhao & Rao, 1995;Chao et al, 1988;Kale et al, 2004;Kokkinos et al, 1993;Leiker et al, 1995;Seifi, Eslami & Saffar, 2003). In contrast to orthopedic studies, which typically show anabolic effects of PGE2 (Norrdin, Jee & High, 1990), studies have reported increase in bone resorption alone (Boekenoogen et al, 1996;Chao et al, 1988;Kale et al, 2004;Leiker et al, 1995;Seifi et al, 2003;Yamasaki, Shibata & Fukuhara, 1982). For ERR, there are studies that report an increase (Boekenoogen et al, 1996;Leiker et al, 1995), but there are also studies that report no significant effect of this molecule (Brudvik & Rygh, 1991).…”

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

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Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 92%

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

See 1 more Smart Citation

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Several authors agreed that corticotomy induces tooth movements rapidly due to increased bone turnover (7)(8)(9). According to this statement, the treatment duration with corticotomy must be shorter than conventional non-surgical orthodontic treatment even for asymmetric dental arch like this case.…”

Section: Discussionmentioning

confidence: 90%

Correction of an asymmetric maxillary dental arch by alveolar bone distraction osteogenesis

Ohba

Tobita

Tajima

et al. 2013

American Journal of Orthodontics and Dentofacial Orthopedics

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This case report describes a new surgical orthodontic approach involving alveolar bone distraction osteogenesis for correction of asymmetric maxillary dental arch. The treatment was also combined with conventional orthognathic surgery to improve mandibular lateral deviation. This new treatment strategy provided an ideal dental arch and a symmetric facial appearance efficiently and effectively. INTRODUCTIONAn asymmetric dental arch associated with skeletal problem often results in an

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“…For this pur po se, the to oth was fi xed in 10% ne ut ral for ma lin so lu ti on for 72 h. Then, it was de cal ci fi ed in de Cas tro so lu ti on for 30 days. 12 De cal ci fi ed to oth samp le was em bed ded in pa raffin and se ri ally sec ti o ned in 5 µm thick ness. The sli ces we re sta i ned with h e ma toxy lin & eo sin (H&E) and Mas son's tric hrom (MT), and exa mi ned under a ref lec ti on con trast mic ros co pe (Le i ca, DMR-RCM, Wetz lar, Ger many).…”

Section: Ca Se Re Portmentioning

confidence: 99%