Comparison of the effects of alendronate sodium and calcitonin on bone–prosthesis osseointegration in osteoporotic rats

Chen, B.-L.; Xie, Denghui; Zheng, Zhou; Lu, WW; Ning, C.-Y.; Li, Y.-Q.; Li, F.-B.; Liao, Weiming

doi:10.1007/s00198-010-1186-5

Cited by 31 publications

(33 citation statements)

References 18 publications

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“…Based on previous literature reports using ALN administration in OVX rats [38][39][40], it was anticipated for the present study that administration of ALN three times per week at a concentration of 2 mg/kg body weight/dose to the rats would be sufficient to prevent the OVX-related bone changes to occur. Indeed, no differences were observed in none of the quantified parameters between shOVX and OVX-ALN groups.…”

Section: Discussionmentioning

confidence: 98%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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Summary High-frequency loading via whole body vibration promotes bone formation and increases bone strength. Whether this translates to positive titanium implant osseointegration in osteoporotic bone was explored in this animal study. An anabolic effect of not only bisphosphonate treatment but also high-frequency loading on implant osseointegration in osteoporotic bone was observed. Introduction The present study investigated the impact of high-frequency (HF) loading, applied via whole body vibration (WBV), on titanium implant osseointegration in healthy versus ovariectomyinduced compromised versus pharmacologically treated compromised bone. Methods A custom-made Ti implant was inserted into the metaphyseal tibia of 59 rats and left to heal for either 4 or 14 days. Rats were divided into six groups according to their hormonal and mechanical status. WBV, consisting of 10 consecutive frequency steps at an acceleration of 0.3g, was applied daily for either 4 or 14 days. Tissue samples were processed for quantitative histology at the tibial cortical and medullar level. Data were analyzed by three-way ANOVA and by post hoc pairwise comparisons. Results The bone healing response at the interface and surrounding titanium implants was negatively influenced by osteoporotic bone conditions, mainly at the trabecular bone level. Furthermore, the administration of bisphosphonates for preventing the ovariectomy-induced impaired periimplant response was successful. Finally, the effect of HF WBV loading on the peri-implant bone healing was dependent on the bone condition and was anabolic solely in untreated osteoporotic trabecular bone when applied for an extended period of time. ConclusionsThe bone healing response to implant installation is compromised in osteoporotic bone conditions, in particular at the trabecular bone compartment. Meanwhile, not only pharmacological treatment but also mechanical loading via HF WBV can exert a positive effect on implant osseointegration in this specific bone micro-environment. The peri-implant cortical bone, however, seems to be less sensitive to HF WBV loading influences.

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Section: Discussionmentioning

confidence: 98%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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“…39–42 Briefly, the two ends of radius were horizontally fixed on the Material Testing System platform (with a span of 2.5 cm between the supports) and a constant vertical compression load (5 mm/min) was applied to the midpoint of the fractured bone until a fracture occurred. The load and displacement data were recorded at 100 Hz.…”

Section: Methodsmentioning

confidence: 99%

Development of injectable citrate-based bioadhesive bone implants

et al. 2015

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Injectable bone implants have been widely used in bone tissue repairs including the treatment of comminuted bone fractures (CBF). However, most injectable bone implants are not suitable for the treatment of CBF due to their weak tissue adhesion strengths and minimal osteoinduction. Citrate has been recently reported to promote bone formation through enhanced bioceramic integration and osteoinductivity. Herein, a novel injectable citrate-based mussel-inspired bioadhesive hydroxyapatite (iCMBA/HA) bone substitute was developed for CBF treatment. iCMBA/HA can be set within 2–4 minutes and the as-prepared (wet) iCMBA/HA possess low swelling ratios, compressive mechanical strengths of up to 3.2±0.27 MPa, complete degradation in 30 days, suitable biocompatibility, and osteoinductivity. This is also the first time to demonstrate that citrate supplementation in osteogenic medium and citrate released from iCMBA/HA degradation can promote the mineralization of osteoblastic committed human mesenchymal stem cells (hMSCs). In vivo evaluation of iCMBA/HA in a rabbit comminuted radial fracture model showed significantly increased bone formation with markedly enhanced three-point bending strength compared to the negative control. Neovascularization and bone ingrowth as well as highly organized bone formation were also observed showing the potential of iCMBA/HA in treating CBF.

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“…Bisphosphonates (BF) are the principal pharmaceutical agents for managing osteoporosis by the inhibition of osteoclasts resorption (21). Studies show that, in osteoporotic condition, bisphosphonates can enhance periprosthesis bone mass and the effects on osseointegration between host bone and prosthesis (22). Moreover, some studies have suggested that bisphosphonates may prevent or may be used to treat aseptic loosening (23), or to prevent the decrease in proximal femoral BMD usually seen after hip replacement (24,25).…”

Section: Discussionmentioning

confidence: 99%

Total hip replacement in osteoarthritis: the role of bone metabolism and its complications

Bottai

Dell’Osso

Celli

et al. 2015

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SummaryOsteoarthritis is one of the most common joint disorder. For treatment of hip symptomatic osteoarthritis, when conservative medical therapy has failed, total hip arthroplasty (THA) is a successful orthopaedic procedures that reduces pain and improves function and quality of life. Incidence of osteoarthritis is constantly increasing with raising life expectancy. This aging process also has led to an increasing number of patients with osteoporosis who need hip replacement for osteoarthritis. Osteoporosis have 3 major potential complications in total hip arthroplasty: perioperative fracture, an increased risk of periprosthetic fracture, and late aseptic loosening. The purpose of the present study was to examine the effects of osteoporosis on total hip replacement procedure outcome and highlight the importance of adequate study of calcium-phosphorus metabolism in patient candidate for hip surgery, and the need to start a suitable therapy to recover the bone mass before surgery. Bone quality of the hip joint has become an important risk factor limiting the durability of THA.KEY WORDS: total hip replacement; bone metabolism; perioperative and periprosthetic fracture.

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Comparison of the effects of alendronate sodium and calcitonin on bone–prosthesis osseointegration in osteoporotic rats

Abstract: In osteoporotic conditions, both administration of ALO orally and CT subcutaneously can enhance periprosthesis bone mass and the effects on osseointegration between host bone and prosthesis. Compared with CT, the effect of ALO is more pronounced.

Cited by 31 publications

References 18 publications

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

Development of injectable citrate-based bioadhesive bone implants

Total hip replacement in osteoarthritis: the role of bone metabolism and its complications

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