Comparison of the Effects of Zolpidem and Triazolam on Memory Functions, Psychomotor Performances, and Postural Sway in Healthy Subjects

Berlin, Ivan; Warot, D.; Hergueta, T.; Molinier, P.; Bagot, Christophe; Puech, Alain J.

doi:10.1097/00004714-199304000-00003

Cited by 86 publications

(44 citation statements)

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“…These effects were seen across measures of attention, memory, and motor coordination. They are consistent with previous studies, where 10 mg of zolpidem at daytime or night-time was found to produce significant impairments of psychomotor performances, attention, and memory from 1-5 h (Berlin et al, 1993;Danjou et al, 1999;Hindmarch et al, 2001) but no residual effects at 8 h or more after administration (Berlin et al, 1993;Fairweather et al, 1992) although delayed memory might be impaired up to 8.25 h after a bedtime administration (Troy et al, 2000). Driving abilities were also impaired 2 h after zolpidem intake, with standard deviations of both speed limit deviation, absolute speed deviation and ideal route deviation, and the number of collisions being significantly affected.…”

Section: Discussionsupporting

confidence: 93%

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

Otmani

Demazieres

Staner

et al. 2008

Human Psychopharmacology

117

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Section: Discussionsupporting

confidence: 93%

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

Otmani

Demazieres

Staner

et al. 2008

Human Psychopharmacology

117

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“…There is evidence that P-4 metabolites interact with the γ-aminobutyric acid (GABA) and the serotonergic system, respectively, and both systems seem to be involved in the pathophysiology of PMS [1]. It is well known that GABA-A receptor-active substances like benzodiazepines, alcohol and also P-4 metabolites influence motor function and balance both in humans and animals [7]. Zolpidem and triazolam for example influence psychomotor performances and postural sway in healthy subjects [8].…”

Section: Introductionmentioning

confidence: 99%

Altered Postural Control during the Luteal Phase in Women with Premenstrual Symptoms

et al. 2005

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The purpose of this study was to investigate postural control in women with and without premenstrual symptoms (PMS) in three hormonally verified phases of the menstrual cycle. Thirty-two women were recruited to participate in the study and 25 of these women were included in the results. Menstrual cycle phases were determined by sex hormone analyses in serum and LH detection in urine. A prospective rating of PMS was used to divide the subjects into two groups: one with PMS (cyclic) and one without (non-cyclic). For measurement of postural control, subjects stood on a force platform (AMTI^®) in two-legged stance (eyes open and closed) and one-legged stance (eyes open and closed). There were no significant differences in the two-legged stance between the phases of the menstrual cycle or between groups. In one-legged stance with eyes open, there was a significant increase in postural displacement in the mid-luteal phase in the cyclic group, but no differences were detected between phases in the non-cyclic group. These findings may be related to the previously reported increased injury rate and psychomotor slowing in the luteal phase in women with PMS.

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“…Treated subjects needed more time between the presentation of target and mask (ie longer interstimulus interval, ISI) in order to identify the target (Emre et al, 1989). Subjects treated with benzodiazepines have also been shown to need more time to distinguish between two consecutive events, that is, treated participants have lower fusion frequency (Danjou et al, 1992;Berlin et al, 1993;Maddock et al, 1993;Curran et al, 1993Curran et al, , 1998MacNab et al, 1985). These two effects suggest that benzodiazepines may affect the time course for the processing of visual information.…”

Section: Introductionmentioning

confidence: 99%

Lorazepam Strongly Prolongs Visual Information Processing

Giersch

Herzog

2004

Neuropsychopharmacol

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Lorazepam is a drug that has been widely used for over 30 years. Whereas its therapeutic and amnestic effects are fairly well known, the visuo-perceptual impairments induced by this drug have been studied to a much lesser degree and only little is known about the influence of lorazepam on the time course of visual information processing. To gain a better insight specifically on these temporal characteristics, we used the recently discovered backward masking technique, 'shine-through', in which a vernier target precedes a grating. We tested subjects, treated with lorazepam, diazepam, or a placebo, with masking gratings of various spatial layouts. Our experiments reveal surprising results. First, for the unmasked vernier target, lorazepam induced a strong deterioration of performance compared to both diazepam and placebo. Performance deteriorated even more significantly if a masking grating was presented following the vernier. We observed that vernier discrimination could be completely abolished even if the grating appeared 400 ms after the vernier presentation. Such long time intervals are beyond usual visual masking effects. When performing the task under placebo, the participants perceived the vernier target and the masking grating as two independent time events rather than as a single event. It appears that lorazepam prolongs dramatically the processing of visual targets. The masking effects revealed here are specific to the type of grating and are much stronger under lorazepam than under diazepam.

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Comparison of the Effects of Zolpidem and Triazolam on Memory Functions, Psychomotor Performances, and Postural Sway in Healthy Subjects

Cited by 86 publications

References 0 publications

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

Altered Postural Control during the Luteal Phase in Women with Premenstrual Symptoms

Lorazepam Strongly Prolongs Visual Information Processing

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