Comparison of the effects of frontal and caudate lesions on delayed response and alternation in monkeys.

Bättig, K.; He, Rosvold; Mishkin, Mortimer

doi:10.1037/h0047392

Cited by 212 publications

(67 citation statements)

References 4 publications

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“…Additional evidence that frontostriatal neural circuitry participates in WM is provided by single unit recordings and lesion studies in animals (Apicella et al, 1992;Battig et al, 1960) and lesion and dysfunction studies in humans (Owen et al, 1997;Partiot et al, 1996). However, the role of this circuitry in WM is not understood.…”

Section: Discussionmentioning

confidence: 99%

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

et al. 2003

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This study describes the neural circuitry underlying temporally separated components of working memory (WM) performance-stimulus encoding, maintenance of information during a delay, and the response to a probe. While other studies have applied event-related fMRI to separate epochs of WM tasks, this study differs in that it employs a methodology that does not make any a priori assumptions about the shape of the hemodynamic response (HDR). This is important because no one model of the HDR is valid across the range of activated brain regions and stimulus types. Systematic modeling inaccuracies may lead to the misattribution of activity to adjacent events. Twelve healthy subjects performed a numerical version of the Sternberg Item Recognition Paradigm adapted for rapid presentation event-related fMRI. This paradigm emphasized maintenance rather than manipulative WM processes and used a subcapacity WM load. WM trials with different delay lengths were compared to fixation. The HDR of the entire WM trial for each trial type was estimated using a finite impulse response (FIR). Regional activity associated with the Encode, Delay, and Probe epochs was identified using contrasts that were based on the FIR estimates and by examining the HDRs. Each epoch was associated with a distinct but overlapping pattern of regional activity. Activation of the dorsolateral prefrontal cortex, thalamus, and basal ganglia was exclusively associated with the probe. This suggests that frontostriatal neural circuitry participates in selecting an appropriate response based on the contents of WM.

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Section: Discussionmentioning

confidence: 99%

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

et al. 2003

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“…Working memory is impaired in human subjects with lesions in the frontal cortex, and particularly the dorsolateral PFC (Freedman and Oscar-Berman, 1986;Verin et al, 1993). Ablation of PFC in non-human primates leads to poor performance in tasks that require working memory (Battig et al, 1960;Goldman et al, 1971). Deficits of working memory are also characteristic of rats with lesions to the medial PFCFthe rodent equivalent of the dorsolateral PFC in primates (Kolb et al, 1974;Larsen and Divac, 1978).…”

Section: Introductionmentioning

confidence: 99%

Regulation of Working Memory by Dopamine D4 Receptor in Rats

Zhang

Grady

Tsapakis

et al. 2004

Neuropsychopharmacol

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Working memory is regulated by neurotransmitters in prefrontal cortex (PFC), including dopamine and norepinephrine. Previous studies of dopamine function in working memory have focused on the D 1 and D 2 receptors, with most evidence suggesting a dominant role for the D 1 receptor. Since the dopamine D 4 receptor is highly expressed in PFC, we hypothesize that it may also contribute to working memory. To test this hypothesis, we examined behavioral effects of L-745,870, a highly selective, centrally active, D 4 antagonist, using a delayed alternation task in rats. Task performance was dose-dependently affected by the D 4 antagonist, depending on individual baseline functional status of working memory. In rats with good baseline performance, the D 4 antagonist had no effects at low doses, whereas high doses disrupted working memory. In rats with poor baseline working memory, the D 4 antagonist significantly improved working memory at low doses, and higher doses were not distinguishable from vehicle controls. Effects of the D 4 antagonist among poor performers were most robust when task demand for working memory was high, with lesser effects at lower demand level, suggesting that such effects were selective for working memory. The present findings indicate a significant role of the D 4 receptor in working memory, and suggest innovative, D 4 -based, treatment of cognitive deficits associated with neuropsychiatric disorders.

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“…Accuracy drops to near-chance levels in monkeys with lesions to Walker's areas 9, 10, and 46, even with delays of mere seconds (see, e.g., Battig, Rosvold, & Mishkin, 1960;Funahashi, Bruce, & Goldman-Rakic, 1993;Goldman & Rosvold, 1970;Goldman, Rosvold, Vest, & Galkin, 1971;Mishkin & Pribram, 1955, 1956Oscar-Berman, 1975;W. A. Wilson, 1962; but see Petrides, 1995).…”

Section: Nonhuman Primate Researchmentioning

confidence: 99%

The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective

Kane

Engle

2002

Psychonomic Bulletin & Review

1,873

1,420

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Comparison of the effects of frontal and caudate lesions on delayed response and alternation in monkeys.

Cited by 212 publications

References 4 publications

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

Regulation of Working Memory by Dopamine D4 Receptor in Rats

The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective

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