Comparison of the efficacy and safety of 5-mg once-daily versus 5-mg alternate-day tadalafil in men with erectile dysfunction and lower urinary tract symptoms

Choi, Hoon; Kim, Jae‐Hun; Shim, JS; Park, Jae Young; Sh, Kang; Dg, Moon; Cheon, Jun; Jg, Lee; Jj, Kim; Jh, Bae

doi:10.1038/ijir.2014.19

Cited by 9 publications

(10 citation statements)

References 34 publications

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“…MPV can be examined in patient with erectile dysfunction because large platelets may be an indicator of the peripheral artery disease and vascular ED. Because MPV is a marker of platelet size that is easily measured by automated blood counters and routinely available at a relatively low cost (4)(5)(6)(7)(8)(9)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

“…According to this, those whose IIEF-ED score was < 26 were regarded to have ED. The patients were grouped according to their erectile function area scores (Q1-5 and Q15) as mild ED (17)(18)(19)(20)(21)(22)(23)(24)(25), moderate ED (11)(12)(13)(14)(15)(16) and severe ED (6)(7)(8)(9)(10). Penile color Doppler evaluation was conducted on the basis of the criteria proposed by La Vignera et al (16).…”

Section: Methodsmentioning

confidence: 99%

“…Additionaly, ED can be an early manifestation of coronary artery and peripheral vascular disease (2). In recent years, there have been some studies which report that mean platelet volume (MPV) increases in patients with vasculogenic ED (4)(5)(6)(7)(8)(9). MPV is a marker of platelet size that is easily measured by automated blood counters and routinely available at a relatively low cost and reflects indirectly platelet activity.…”

Section: Introductionmentioning

confidence: 99%

“…Increased platelet activity probably plays a role in the etiopathogenesis of vasculogenic ED with such atherothrombotic process. The relationship between vasculogenic ED and platelet activity has been investigated in some studies (4)(5)(6)(7)(8)(9). But these studies contain some conflicting results.…”

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confidence: 99%

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Blood platelet activity in men with vasculogenic erectile dysfunction

Bayraktar

Albayrak

2017

Arch Ital Urol Androl

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Objective: The aim of this study was to investigate the platelet activity in patients with vasculogenic erectile dysfunction (ED). Materials and methods: The total blood count, including hemoglobin (Hgb), white blood cell (WBC), red blood cell (RBC), platelet (PLT) and mean platelet volume (MPV) parameters were measured in the patient (n = 70) and control groups (n = 50). Results: The average age was 48.1 ± 11.7 and 47.6 ± 12.3 in the patient and control groups (p = 0.8217), respectively. MPV was higher in the patient group and there was a statistically significant difference between two groups (11.27 ± 0.56 and 9.8 ± 0.91, p < 0.0001). PLT counts were lower in the patient group but there was not a statistically significant difference (196.23 ± 37.01 and 209.07 ± 36.71, p = 0.0626). In terms of haemoglobin, WBC and RBC values, there was no difference in the patient and control groups. Conclusions: Finding high MPV, which reflects the platelet activity, in the patient group shows that platelets also have a role in the VED etiopathogenesis. In the case of the confirmation of this result with additional studies, the efficiency of anti-platelet therapy in the vasculogenic ED should also be researched.KEY WORDS: Erectile dysfunction; Platelet; Mean platelet volume. most potent vasoconstrictor agent. Therefore increased platelet activity play an important role in the atherosclerosis formation through mechanisms such as thrombocyte gathering, tromboxan synthesis, and expression of adhesion molecules (10-13). Increased platelet activity probably plays a role in the etiopathogenesis of vasculogenic ED with such atherothrombotic process. The relationship between vasculogenic ED and platelet activity has been investigated in some studies (4-9). But these studies contain some conflicting results. For example, while Çiftçi et al. (8) stated that both platelet count (PLT) and mean platelet volume (MPV) increased in vasculogenic ED, Aldemir et al. (9) reported that platelet count was normal. In this study, it was aimed to investigate some hematological parameters such as hemoglobin (Hgb), white blood cell (WBC), red blood cell (RBC), PLT and MPV in patients with vasculogenic ED. MATERIALS AND METHODSThe study protocol was approved by the Institutional Ethics Committee of the School of Medicine, Istanbul Medipol University, Turkey. All of the individuals gave their informed consent. 70 patients in total who came to the Urology polyclinic between May 2015 and June 2016 with the ED complaint and were diagnosed with vasculogenic ED (arterial insufficiency) were included in this study. All the patients in this group were subjected to the detailed history (anamnesis), physical examination, erectile function examination, laboratory evaluations and penile colour Doppler ultrasonography (pDUS). The ED level was questioned by International Index of Erectile Function (IIEF) which had 6 questions consisting of the 1-5 and 15 th questions of the IIEF questionnaire (14, 15). According to this, those whose IIEF-ED score was < 26 were regarde...

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Blood platelet activity in men with vasculogenic erectile dysfunction

Bayraktar

Albayrak

2017

Arch Ital Urol Androl

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“…However, tadalafil, unique among other PDE5 inhibitors, has demonstrated efficacy up to 36 h and is not affected by the intake of food [7] . Thus, tadalafil could be taken regularly, such as once a day, to provide continuous efficacy, which would enable patients to engage in sexual intercourse at any time, eliminating the need to take a dose before intercourse [8] .…”

mentioning

confidence: 99%

Efficacy and Safety of Tadalafil Once-a-Day versus Tadalafil On-Demand in Patients with Erectile Dysfunction: A Systematic Review and Meta-Analyses

et al. 2017

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Introduction: To compare the efficacy and safety between tadalafil once-a-day and tadalafil on-demand dosing regimen in patients with ED. Materials and Methods: A systematic search of Medline, Embase, and Cochrane Library was performed to identify all randomized controlled trials (RCTs) that compared tadalafil used a once-a-day with an on-demand dosing regimen for erectile dysfunction. A secondary hand-search was performed in relevant journals, references, and the grey literature. Meta-analyses were performed using Review Manager version 5.3.0. Results: Six RCTs involving a total of 1,534 patients were included in this review. All studies reported the International Index of Erectile Function-Erectile Function domain score and the results of the meta-analysis showed no difference between the groups. The overall pooled estimated weighted mean differences (WMD) was 0.97 (95% CI -0.37 to 2.32; p = 0.16). Meta-analyses of Sexual Encounter Profile questions 2 and 3 (SEP-2 and SEP-3) showed that the once-a-day dosing regimen was superior to the on-demand regimen with statistical significance. The WMD of SEP-2 and SEP-3 were 10.32 (95% CI 3.16-17.48; p = 0.005) and 11.07 (95% CI 2.57-19.56; p = 0.01), respectively. Both dosing regimens of tadalafil showed similar complication rates. The meta-analyses of adverse events showed no significant differences. Conclusions: The efficacy rates of tadalafil once-a-day and on-demand were similar. No significant difference in safety was found between the 2 dose regimens of tadalafil.

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