Comparison of the Efficacy and Safety of Pantoprazole Magnesium and Pantoprazole Sodium in the Treatment of Gastro-Oesophageal Reflux Disease

Abstract

Pantoprazole-Mg is clinically as effective and well tolerated as pantoprazole-Na in the treatment of GORD stages I-III, demonstrating non-inferiority for oesophageal healing at 8 weeks and superior healing rates at 4 weeks associated with high levels of symptomatic relief.

Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group

“…AE reporting for pantoprazole-Mg appears to be lower than that captured in the randomized clinical trial discussed above 6. No unexpected AEs were reported.…”

“…Although proton pump inhibitors (PPIs), the most potent therapeutic option for GERD, have been shown to improve night-time symptoms of GERD, some patients continue to experience breakthrough symptoms 4. This may reflect a wearing off of the acid suppressive effect of PPIs towards the end of the dosing interval, due to the rebound of acidity levels through a combination of proton pump regeneration and the short half-life of PPIs 5,6…”

“…Safety profile on the other hand should be comparable, since the overall exposure of both drugs is similar. Although pantoprazole-Mg has been shown to be as effective as pantoprazole-Na in relieving a broad range of gastrointestinal symptoms associated with GERD,6 its effectiveness in controlling night-time GERD symptoms has not been previously evaluated. The presence of night-time heartburn has been linked to a high likelihood of esophagitis and extra-esophageal symptoms 7…”

Randomised clinical trial: daily pantoprazole magnesium 40 mg vs. esomeprazole 40 mg for gastro-oesophageal reflux disease, assessed by endoscopy and symptoms

“…At 8 weeks, healing rates with pantoprazole‐Mg were similar to those with pantoprazole‐Na (87.3% vs. 85.0%); however, after 4 weeks of treatment, pantoprazole‐Mg achieved a superior healing rate over that with pantoprazole‐Na (72.7% vs. 66.2%). This was associated with numerically higher rates of symptom relief across a broad range of symptoms at 4 weeks in the pantoprazole‐Mg group than those in the pantoprazole‐Na group …”

“…Pantoprazole‐Mg has been shown to be at least as effective as pantoprazole‐Na in oesophageal healing and relief of a broad range of gastrointestinal symptoms associated with GERD . At 8 weeks, healing rates with pantoprazole‐Mg were similar to those with pantoprazole‐Na (87.3% vs. 85.0%); however, after 4 weeks of treatment, pantoprazole‐Mg achieved a superior healing rate over that with pantoprazole‐Na (72.7% vs. 66.2%).…”