Comparison of the efficacy and safety of using 0.01% versus 0.03% bimatoprost for the treatment of eyebrow hypotrichosis: A randomized, double‐blind, split‐face, comparative study

Abstract

Background Previous studies have proven the efficacy and safety of 0.01% and 0.03% bimatoprost for the treatment of eyebrow hypotrichosis; however, there is no comparison study between both concentrations. Aims To compare the efficacy and safety between 0.01% and 0.03% bimatoprost for the treatment of eyebrow hypotrichosis. Patients/Methods This prospective, randomized, double‐blind, split‐face clinical study was conducted in 30 patients with eyebrow hypotrichosis. Each side of eyebrow of individual patients was randomly assigned for 0.01% and 0.03% bimatoprost, applied on each eyebrow once daily. Eyebrow density, diameter, the Global Eyebrow Assessment scale, 7‐point rating scale, and patient satisfaction were evaluated. Side effects were also recorded. Results Both 0.01% and 0.03% bimatoprost significantly improved eyebrow density and diameter (P < .05), although there were no statistically significant differences in changes in eyebrow density and diameter from baseline between both concentrations (P = .96 and .84, respectively). Additionally, patients significantly preferred 0.03% bimatoprost in terms of clinical improvement and satisfaction (P = .04 and .003, respectively). Conclusions Both 0.01% and 0.03% bimatoprost are effective and safe for the treatment of eyebrow hypotrichosis. Bimatoprost 0.03% is superior to its 0.01% counterpart, albeit without statistical significance.

Eyebrow growth pattern analysis in patients with eyebrow hypotrichosis after receiving topical treatment: A retrospective study

“…Data were obtained from two clinical trials of bimatoprost for the treatment of eyebrow hypotrichosis. 15,16 Participants in previous studies were healthy males and females with idiopathic eyebrow hypotrichosis receiving a 0.01% bimatoprost once-daily treatment for 24 weeks. Only data with a full 24-week record of follow-up were included in this study.…”

“…5,7 The effectiveness of bimatoprost as a topical treatment of eyebrow hypotrichosis has been reported in four case reports and five randomized controlled trials. [8][9][10][11][12][13][14][15][16] Prior clinical experience and previous studies of topical bimatoprost for the treatment of eyebrow hypotrichosis have led to remarkable observations in eyebrow growth patterns. 15,16 Each eyebrow segment, in addition to having distinct characteristics, had observable variations in eyebrow growth rates after receiving the topical treatment.…”

“…[8][9][10][11][12][13][14][15][16] Prior clinical experience and previous studies of topical bimatoprost for the treatment of eyebrow hypotrichosis have led to remarkable observations in eyebrow growth patterns. 15,16 Each eyebrow segment, in addition to having distinct characteristics, had observable variations in eyebrow growth rates after receiving the topical treatment. Although eyebrow dimensions have been studied, an indepth survey of eyebrow hair density and diameter as well as the growth pattern of each part of the eyebrow has not been performed.…”

“…Prior clinical experience and previous studies of topical bimatoprost for the treatment of eyebrow hypotrichosis have led to remarkable observations in eyebrow growth patterns . Each eyebrow segment, in addition to having distinct characteristics, had observable variations in eyebrow growth rates after receiving the topical treatment.…”

“…Available treatment options include topical therapy, eyebrow transplantation, and aesthetic camouflage . The effectiveness of bimatoprost as a topical treatment of eyebrow hypotrichosis has been reported in four case reports and five randomized controlled trials …”