Comparison of the Efficacy between the Single-Dose and Three-Day Prophylactic Antibiotic Regimens for the Prevention of Bacterial Infections in Patients with Percutaneous Nephrolithotomy: A Randomized Controlled Study

Chae, Han Kyu; Kim, Myong; Shin, Jung Hyun; Park, Hyung Keun

doi:10.14777/uti.2018.13.3.66

Cited by 2 publications

(9 citation statements)

References 17 publications

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“…Fever was compared between the use of single and extended doses of antibiotics in seven studies [4,[10][11][12][13][14]16], but no significant differences were observed (p = 0.93, OR = 0.96, 95% CI 0.44-2.13, I 2 = 64%) (Fig 3). Risk classification subgroup analysis was not performed, as there were no statistically significant differences between the broader groups.…”

Section: Complication Ratesmentioning

confidence: 99%

“…A total of 831 studies were identified for potential inclusion in the meta-analysis. After a fulltext review, 10 articles were identified as relevant for this study and selected for inclusion in the meta-analysis (Fig 1) [4,5,[9][10][11][12][13][14][15][16].…”

Section: Eligible Studiesmentioning

confidence: 99%

“…The characteristics of the 10 included studies are shown in Table 1 [4,5,[9][10][11][12][13][14][15][16]. These comparative studies described patients who underwent antibiotic prophylaxis for PCNL for renal stones.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Five studies were performed in Europe (four studies from Turkey and one study from the UK) [5,9,10,15,16]. Three studies were performed in Asia (China, India, and South Korea) [4,11,12], and one study was performed in the U.S [14]. Additionally, one study was conducted in Egypt [13].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Additionally, one study was conducted in Egypt [13]. Four studies were selected based on the inclusion of a high-risk patient group [4,5,14,16]; six other studies were chosen but did not specify the patient group [9][10][11][12][13]15]. Four studies were selected based on the use of an "extended preop" [4,5,12,14], whereas six other studies were chosen due to the use of an "extended periop" [9-11, 13, 15, 16].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis

et al. 2022

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Introduction A single dose of preventive antibiotics is known to be sufficient to reduce the rate of infection-related complications in percutaneous nephrolithotomy (PCNL). However, some studies reported that the extended dose showed lower complications for high-risk groups. Therefore, we performed a systematic review and meta-analysis comparing single- and extended-dose antibiotic prophylaxis for PCNL. Materials and methods Relevant studies that compared single- and extended-dose antibiotic prophylactic therapies were identified. Articles were selected from PubMed, EMBASE, KoreaMed, and Google Scholar up to September 2021. Fever and systemic inflammatory response syndrome (SIRS) were compared by meta-analysis. A subgroup analysis was performed according to the degree of risk to the patient. Results A total of 10 articles were included in this study. There were no significant differences between single dose and extended dose in the rate of fever [p = 0.93, OR = 0.96, 95% confidence interval (CI) 0.44–2.13, I2 = 64%]. Extended dose showed lower rate of SIRS compared to single dose (p = 0.0005, OR = 1.81, 95% CI 1.30–2.53, I2 = 53%); in the subgroup analysis, extended dose also showed lower rates of SIRS compared to single dose in high-risk patients (p <0.0001, OR = 3.53, 95% CI 1.91–6.54, I2 = 36%). Conclusions The results of our meta-analysis showed that single-dose antibiotic prophylaxis can be effective for PCNL, but extended-dose antibiotics can be required in high-risk patients to reduce post-PCNL infection-related complications.

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Section: Complication Ratesmentioning

confidence: 99%

Section: Eligible Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis

et al. 2022

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Postoperative antibiotic prophylaxis for percutaneous nephrolithotomy and risk of infection: a systematic review and meta-analysis

Talizin,

Danilovic,

Torricelli

et al. 2024

Int. braz j urol.

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Purpose: The aim of this study is to perform a high-quality meta-analysis using only randomized controlled trials (RCT) to better define the role of postoperative antibiotics in patients undergoing percutaneous nephrolithotomy (PCNL). Materials and Methods: A literature search for RCTs in EMBASE, PubMed, and Web of Science up to May 2023 was conducted following the PICO framework: Population—adult patients who underwent PCNL; Intervention—postoperative antibiotic prophylaxis until nephrostomy tube withdrawal; Control—single dose of antibiotic during the induction of anesthesia; and Outcome—systemic inflammatory response syndrome (SIRS) or sepsis and fever after PCNL. The protocol was registered on the PROSPERO database (CRD42022361579). We calculated odds ratios (OR) and 95% confidence intervals (CI). A random-effects model was employed, and the alpha risk was defined as < 0.05. Results: Seven articles, encompassing a total of 629 patients, were included in the analysis. The outcome of SIRS or sepsis was extracted from six of the included studies, while the outcome of postoperative fever was extracted from four studies. The analysis revealed no statistical association between the use of postoperative antibiotic prophylaxis until nephrostomy tube withdrawal and the occurrence of SIRS/sepsis (OR 1.236, 95% CI 0.731 – 2.089, p=0.429) or fever (OR 2.049, 95% CI 0.790 – 5.316, p=0.140). Conclusion: Our findings suggest that there is no benefit associated with the use of postoperative antibiotic prophylaxis until nephrostomy tube withdrawal in patients undergoing percutaneous nephrolithotomy (PCNL). We recommend that antibiotic prophylaxis should be administered only until the induction of anesthesia in PCNL.

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Comparison of the Efficacy between the Single-Dose and Three-Day Prophylactic Antibiotic Regimens for the Prevention of Bacterial Infections in Patients with Percutaneous Nephrolithotomy: A Randomized Controlled Study

Cited by 2 publications

References 17 publications

Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis

Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis

Postoperative antibiotic prophylaxis for percutaneous nephrolithotomy and risk of infection: a systematic review and meta-analysis

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