Comparison of the efficacy of pantoprazole vs. nizatidine in the treatment of erosive oesophagitis: a randomized, active‐controlled, double‐blind study

Abstract

SUMMARYBackground: Pantoprazole is a proton pump inhibitor approved for the treatment of erosive oesophagitis and gastro-oesophageal reflux disease. Aim: To compare the efficacy and safety of pantoprazole vs. nizatidine for the treatment of symptomatic gastrooesophageal reflux disease and endoscopically documented erosive oesophagitis (grade ‡ 2). Methods: A multicentre, double-blind, randomized, active-controlled study (221 patients) was performed to compare 20 and 40 mg pantoprazole daily with nizatidine 150 mg b.d. (maximum, 8 weeks). The primary end-point was endoscopic healing of erosive oesophagitis (grade 1 or 0). The secondary end-point was symptomatic improvement. Results: Healing averaged 61%, 64% and 22% for pantoprazole 20 mg, pantoprazole 40 mg and nizatidine

Novel Measurement of Rapid Treatment Success with ReQuest^TM: First and Sustained Symptom Relief as Outcome Parameters in Patients with Endoscopy-Negative GERD Receiving 20 mg Pantoprazole or 20 mg Esomeprazole

“…PPIs are the current treatment of choice for patients with GERD; PPI treatment provides the most rapid symptomatic control of all available agents, and this study is in accordance with the literature showing that treatment effect can be achieved within a matter of days [1, 2, 29, 30]. In patients with erosive GERD, Castell et al [22] reported a median time to first resolution of diary-recorded heartburn of 2 days and a median time to sustained resolution of diary-recorded heartburn of 7 days, with 40 mg esomeprazole (ITT population).…”

A Pilot Study of Efficacy and Safety of Continuous Intravenous Infusion of Pantoprazole in the Treatment of Severe Erosive Esophagitis

“…Among conventional medications, proton pump inhibitors (PPIs) are by far the most potent medications for treating reflux esophagitis, especially erosive esophagitis, because of their potent acid suppression effect [1]. Effects of PPIs on erosive esophagitis have been studied in randomized controlled trials [5][6][7][8]. In general, those studies demonstrated a high healing rate (83-94%) of erosive esophagitis in those treated by PPI for 8 weeks and a relatively lower healing rate (64-82%) at 4 weeks [5][6][7][8].…”

“…Published studies have demonstrated that 40 mg of pantoprazole orally once a day was effective for treating erosive esophagitis [7] and was superior to nizatidine [8]. Pantoprazole is one of the few PPIs available on the US market for intravenous administration.…”

Intravenous Pantoprazole as Initial Treatment in Patients With Gastroesophageal Reflux Disease and a History of Erosive Esophagitis: A Randomized Clinical Trial

“…Oral pantoprazole, a proton pump inhibitor (PPI), is efficacious in healing erosive esophagitis (EE) and controlling associated symptoms [1,2]. Additional studies have demonstrated efficacy in maintaining healing of EE and preventing recurrence of GERD symptoms over 1 year of treatment [3,4].…”