Comparison of the efficacy of topical 1% lindanevs5% permethrin in scabies: A randomized, double-blind study

Abstract

Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies in comparison with lindane in this study, and it seems that it could be an alternative treatment.

Comparative Study of Efficacy of Oral Ivermectin Versus Some Topical Antiscabies Drugs in the Treatment of Scabies

“…3) Topical GBhC 1% lotion: Earlier studies [8,[11][12][13] have reported <75% cure rate with 1% topical GBHC lotion. Nag et al, [13] have reported a cure rate of 68% only with 2% GBHC 2 applications in a day.…”

“…2) Topical Permethrin 5% cream single application: Earliar studies [4,[8][9][10] have reported cure rate >80% with Permethrin. Higher cure rates (98%) was reported after two applications.…”

Topical permethrin and oral ivermectin in the management of scabies: A prospective, randomized, double blind, controlled study

“…[4] Permethrin 5% cream has been found to be more effective as compared to lindane and is FDA approved for the treatment of scabies. [5,6] In developing countries like India where the disease is largely prevalent in the lower socioeconomic strata, acquiring permethrin is considered an expensive option. Besides, whole body application for hours together is inconvenient and leads to poor compliance.…”

Study of efficacy of oral ivermectin in comparison to commonly used topical antiscabetic drugs gamma benzene hexachloride and permethrin

“…11,12 Similarly Hegary et al and Usha et al found permethrin to be effective as a single application with cure rate of 84.9% and 97.8% respectively. 13,5 Topical GBHC 1% lotion (single application)…”

“…Taplin et al, Zargari M et al, Chouela et al, have found 65%, 48.9%, 44.44%, 54% cure rate respectively with 1% lindane lotion after 1 month. [10][11][12]14 Comparison of statistical significance among three groups Difference in efficacy of group I (ivermectin) therapy was statistically non-significant with group II (permethrin) but statistically significant with group III (gama benzene hexachloride). This shows that efficacy of group I therapy was comparable to group II therapy but more efficacious than group III therapy.…”