Comparison of the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using Quantitative Light-induced Fluorescence

Srisilapanan, Patcharawan; Korwanich, Narumanas; Yin, Wei; Chuensuwonkul, C.; Mateo, Luis R; Zhang, Y.P.; Cummins, D.; Ellwood, R.P.

doi:10.1016/j.jdent.2010.04.005

Cited by 59 publications

(80 citation statements)

References 12 publications

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“…This is consistent with studies (no meta-analysis available) on enamel caries lesions in 7-to 14-y-old patients (Srisilapanan et al 2013;. Nonetheless, evidence level was graded as very low, and both studies included in this meta-analysis showed a high risk of bias, indicating that further high-qualitative clinical studies are warranted.…”

Section: Discussionsupporting

confidence: 86%

Systematic Review on Noninvasive Treatment of Root Caries Lesions

2014

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The present systematic review critically summarizes results of clinical studies investigating chemical agents to reduce initiation or inactivation of root caries lesions (RCLs). Outcomes were DMFRS/DFRS (decayed, missing, filled root surfaces), surface texture (hard/soft), and/or RCI (root caries index). Three electronic databases were screened for studies from 1947 to 2014. Cross-referencing was used to further identify articles. Article selection and data abstraction were done in duplicate. Languages were restricted to English and German. Mean differences (MD) were calculated for changes in DMFRS/DFRS. Risk ratios (RR) were calculated for changes in surface texture and RCI in a random effects model. Thirty-four articles with 1 or more agents were included; they reported 30 studies with 10,136 patients who were 20 to 101 y old; and they analyzed 28 chemical agents (alone or in combination). Eleven studies investigated dentifrices, 10 rinses, 8 varnishes, 3 solutions, 3 gels, and 2 ozone applications. Meta-analyses revealed that dentifrices containing 5,000 ppm Regular use of dentifrices containing 5,000 ppm F -and quarterly professionally applied CHX or SDF varnishes seem to be efficacious to decrease progression and initiation of root caries, respectively. However, this conclusion is based on only very few well-conducted randomized controlled trials.

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Section: Discussionsupporting

confidence: 86%

Systematic Review on Noninvasive Treatment of Root Caries Lesions

2014

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“…For this reason, a silica-based sodium fluoride dentifrice was used as the control formulation in this study. Amongst the five clinical studies of 6 months duration and the in situ clinical studies which demonstrated the great promise of this technology, several have used calcium-based sodium monofluorophosphate toothpastes as matched controls and have also demonstrated superior anti-caries efficacy for the toothpaste containing 1.5% arginine [Cantore et al, 2013;Souza et al, 2013;Srisilapanan et al, 2013].…”

Section: Discussionmentioning

confidence: 99%

“…Three studies, using quantitative light-induced fluorescence, have each shown that the new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm F is significantly more effective in arresting and reversing coronal caries lesions in children than a dentifrice containing 1,450 ppm F alone [Srisilapanan et al, 2013;Yin et al, 2013a, b]. In one study, after 6 months of product use, improvements from baseline in ΔQ (lesion volume) were 50.7, 32.3 and 11.4% for the new arginine-containing dentifrice, a matched positive control dentifrice and a matched negative control dentifrice, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…This clinical validation comprises a series of five studies of 6 months duration which assessed the efficacy in arresting and reversing (re-mineralizing) early, reversible enamel lesions and root caries lesions. The studies demonstrated that innovative dentifrices containing 1.5% arginine, an insoluble calcium compound and fluoride [Cummins, 2013] provide superior caries benefits in children and adults to dentifrices containing fluoride alone [Hu et al, 2013;Souza et al, 2013;Srisilapanan et al, 2013;Yin et al, 2013a, b]. Further, it includes in situ clinical studies which showed that these dentifrices inhibit de-mineralization and enhance re-mineralization more effectively than dentifrices with fluoride alone [Cantore et al, 2013].…”

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confidence: 99%

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Two-Year Caries Clinical Study of the Efficacy of Novel Dentifrices Containing 1.5% Arginine, an Insoluble Calcium Compound and 1,450 ppm Fluoride

et al. 2013

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A 2-year double-blind randomized three-treatment controlled parallel-group clinical study compared the anti-caries efficacy of two dentifrices containing 1.5% arginine, an insoluble calcium compound (di-calcium phosphate or calcium carbonate) and 1,450 ppm fluoride (F), as sodium monofluorophosphate, to a control dentifrice containing 1,450 ppm F, as sodium fluoride, in a silica base. The 6,000 participants were from Bangkok, Thailand and aged 6-12 years initially. They were instructed to brush twice daily, in the morning and evening, with their randomly assigned dentifrice. Three trained and calibrated dentists examined the children at baseline and after 1 and 2 years using the National Institute of Dental Research Diagnostic Procedures and Criteria. The number of decayed, missing and filled teeth (DMFT) and surfaces (DMFS) for the three study groups were very similar at baseline, with no statistically significant differences among groups. After 1 year, there were no statistically significant differences in caries increments among the three groups. After 2 years, the two groups using the dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm F had statistically significantly (p < 0.02) lower DMFT increments (21.0 and 17.7% reductions, respectively) and DMFS increments (16.5 and 16.5%) compared to the control dentifrice. The differences between the two groups using the new dentifrices were not statistically significant. The results of this pivotal clinical study support the conclusion that dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm F provide significantly greater protection against caries lesion cavitation, in a low to moderate caries risk population, than dentifrices containing 1,450 ppm F alone.

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“…It may act directly on plaque biofilm, maintaining plaque slightly supersaturated with respect to the tooth mineral Srisilapanan et al, 2013], but dental erosion occurs in the absence of plaque. In vitro studies on erosion showed the formation of a calcium-rich layer over demineralized enamel [Rege et al, 2014], where it is thought that arginine modifies the surface charge of enamel, heightening the affinity of calcium carbonate for the tooth surface [Rege et al, 2014].…”

Section: Amino Acids Peptides Proteins or Polymers Products Containmentioning

confidence: 99%

The Future of Fluorides and Other Protective Agents in Erosion Prevention

Lussi

Carvalho²

2015

Caries Res

139

136

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The effectiveness of fluoride in caries prevention has been convincingly proven. In recent years, researchers have investigated the preventive effects of different fluoride formulations on erosive tooth wear with positive results, but their action on caries and erosion prevention must be based on different requirements, because there is no sheltered area in the erosive process as there is in the subsurface carious lesions. Thus, any protective mechanism from fluoride concerning erosion is limited to the surface or the near surface layer of enamel. However, reports on other protective agents show superior preventive results. The mechanism of action of tin-containing products is related to tin deposition onto the tooth surface, as well as the incorporation of tin into the near-surface layer of enamel. These tin-rich deposits are less susceptible to dissolution and may result in enhanced protection of the underlying tooth. Titanium tetrafluoride forms a protective layer on the tooth surface. It is believed that this layer is made up of hydrated hydrogen titanium phosphate. Products containing phosphates and/or proteins may adsorb either to the pellicle, rendering it more protective against demineralization, or directly to the dental hard tissue, probably competing with H+ at specific sites on the tooth surface. Other substances may further enhance precipitation of calcium phosphates on the enamel surface, protecting it from additional acid impacts. Hence, the future of fluoride alone in erosion prevention looks grim, but the combination of fluoride with protective agents, such as polyvalent metal ions and some polymers, has much brighter prospects.

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Comparison of the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using Quantitative Light-induced Fluorescence

Cited by 59 publications

References 12 publications

Systematic Review on Noninvasive Treatment of Root Caries Lesions

Systematic Review on Noninvasive Treatment of Root Caries Lesions

Two-Year Caries Clinical Study of the Efficacy of Novel Dentifrices Containing 1.5% Arginine, an Insoluble Calcium Compound and 1,450 ppm Fluoride

The Future of Fluorides and Other Protective Agents in Erosion Prevention

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