Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

Liu, Fang; Luo, Yingzhi; Chen, Huan; Xu, Shengjing; Zhang, Dongyan; Sang, Hong; Xu, Chenjie; Zhang, Min

doi:10.1039/d2na00604a

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…Upon penetration into the dermis layer, these MNs with a height of 500-1000 μm notably impeded the fibroblasts and modified the expression of collagen deposition, α-SMA, nucleus-related antigen protein (Ki-67), and TGF-β1 mRNA, thus alleviating skin scarring to some extent. [122] With the development of pathological fibrosis, myofibroblasts gradually show The produced PQBH-n nanofibers are multifunctional and remodel the harsh hypoxic microenvironment owing to the all-in-one bioactive properties, such as nearinfrared (NIR)-assisted oxygen delivery, hemostasis, and antibacterial and anti-inflammatory properties, thereby promoting cell proliferation, migration, and vascularization. Reproduced with permission.…”

Section: Microneedles (Mns)mentioning

confidence: 99%

Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis

Kang,

Liu,

Chen

et al. 2024

Advanced NanoBiomed Research

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Skin pathological fibrosis conditions, such as hypertrophic scars (HS) and keloids, where the scar tissue is raised and extends beyond the original wound boundary, are aesthetically unappealing and sometimes painful or itchy, significantly impacting the life quality of patients. In this review, the advances of nanobiomaterials in treating skin pathological fibrosis are summarized and discussed. The focus is on the therapeutic approaches to cellular and molecular targets of HS, highlighting the potential of nanotechnology in scar management. The biofunctional nanomaterials can modulate inflammation, regulate angiogenesis, and promote fibroblast apoptosis. The nanotechnology‐based drug delivery systems such as liposomes, ethosomes, and dendritic macromolecules can improve the solubility, stability, and efficacy of drugs, and enhance precise delivery, resulting in better outcomes in HS therapy. Integrating nanomaterials or nanostructures into hydrogels, nanofibers, and microneedles can enhance the biological functionality and maximize the therapeutic effect of nanoparticles (NPs) at the wound site. The important potential of nanotechnology‐based scar treatment should be further explored to overcome the current challenges and promote its application in clinical practice.

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Section: Microneedles (Mns)mentioning

confidence: 99%

Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis

Kang,

Liu,

Chen

et al. 2024

Advanced NanoBiomed Research

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“…A recent comparative study of different polymeric needles revealed that PMMA MNs are superior in the decline of tissue fibrosis and the expression of proinflammatory factors viz. smooth muscle actin (α-SMA) + myobroblasts, Ki-67 protein, and transforming growth factor-β1 mRNA, when compared with polycarbonates, polylactic-co-glycolic acid, polypropylene, polyurethane, liquid crystal polymers, and stainless steel [68]. Passivation techniques improve the performance of the MN-based biosensors.…”

Section: Polymethyl Methacrylate (Pmma)mentioning

confidence: 99%

Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

Kulkarni,

Gadade,

Chapaitkar

et al. 2023

Sci. Pharm.

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Microneedles are gaining popularity as a new paradigm in the area of transdermal drug delivery for biomedical and healthcare applications. Efficient drug delivery with minimal invasion is the prime advantage of microneedles. The concept of the microneedle array provides an extensive surface area for efficient drug delivery. Various types of inorganics (silicon, ceramic, metal, etc.) and polymeric materials are used for the fabrication of microneedles. The polymeric microneedles have various advantages over other microneedles fabricated using inorganic material, such as biocompatibility, biodegradation, and non-toxicity. The wide variety of polymers used in microneedle fabrication can provide a broad scope for drug delivery and other biomedical applications. Multiple metallic and polymeric microneedles can be functionalized by polymer coatings for various biomedical applications. The fabrication of polymeric microneedles is shifting from conventional to advanced 3D and 4D printing technology. The multifaceted biomedical applications of polymeric microneedles include drug delivery, vaccine delivery, biosensing, and diagnostic applications. Here, we provide the overview of the current and advanced information on polymers used for fabrication, the selection criteria for polymers, biomedical applications, and the regulatory perspective of polymer-based and polymer-coated microneedles, along with a patent scenario.

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“…Microneedles can increase skin permeability, increase drug concentration in local skin lesions, and reduce systemic toxicity. Microneedles have been used to treat a variety of common skin conditions, such as acne, hair loss [116][117][118], atopic dermatitis (AD) [119][120][121][122][123], psoriasis [124][125][126][127], and scarring [128][129][130][131][132][133][134].…”

Section: Dissolving Microneedle For Cutaneous Diseasementioning

confidence: 99%

The Progress in the Application of Dissolving Microneedles in Biomedicine

Yu,

Zhao,

Fan

2023

Polymers

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In recent years, microneedle technology has been widely used for the transdermal delivery of substances, showing improvements in drug delivery effects with the advantages of minimally invasive, painless, and convenient operation. With the development of nano- and electrochemical technology, different types of microneedles are increasingly being used in other biomedical fields. Recent research progress shows that dissolving microneedles have achieved remarkable results in the fields of dermatological treatment, disease diagnosis and monitoring, and vaccine delivery, and they have a wide range of application prospects in various biomedical fields, showing their great potential as a form of clinical treatment. This review mainly focuses on dissolving microneedles, summarizing the latest research progress in various biomedical fields, providing inspiration for the subsequent intelligent and commercial development of dissolving microneedles, and providing better solutions for clinical treatment.

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Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

Abstract: Microneedle technology can effectively suppress the formation of hypertrophic scarring in both animal and human. Our previous research has revealed that this is due to the physical contact inhibition effect...

Cited by 8 publications

References 22 publications

Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis

Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis

Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

The Progress in the Application of Dissolving Microneedles in Biomedicine

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