Comparison of the eighth edition of the TNM and Brigham Women’s Hospital staging systems for cutaneous squamous cell carcinoma of the head and neck: a six-year review

Bowe, C.M.; Walsh, Stephen R.

doi:10.1016/j.bjoms.2021.05.014

Cited by 1 publication

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 In terms of RLNM and DSD, poor outcomes occurred more frequently in the cohort with BWH low-T stage (63%) than in the cohort with eighth UICC low-T stage (38%). 19 However, the current eighth UICC and eighth AJCC staging systems are not commonly used for cSCCs at all skin sites, as previously mentioned.…”

Section: Discussionmentioning

confidence: 91%

“…In both the staging systems, higher T stages were associated with higher rates of LR, RLNM, and DSD 19 . Meanwhile, poor outcomes (LR, RLNM, or DSD) occurred more frequently in the cohort with BWH low‐T stages (T1 and T2a, 79%) than in the cohort with eighth UICC low‐T stages (T1 and T2, 58%) 19 . In terms of RLNM and DSD, poor outcomes occurred more frequently in the cohort with BWH low‐T stage (63%) than in the cohort with eighth UICC low‐T stage (38%) 19 .…”

Section: Discussionmentioning

confidence: 94%

“…This finding showed that compared to the eighth AJCC T staging, the BWH staging clearly discriminated the patients who would develop DSD even in the head and neck region 18 . Meanwhile, conflicting results were reported in a study that compared the prognosis of 604 patients with head and neck cSCC according to the eighth UICC T and BWH staging systems 19 . In both the staging systems, higher T stages were associated with higher rates of LR, RLNM, and DSD 19 .…”

Section: Discussionmentioning

confidence: 96%

“…Meanwhile, poor outcomes (LR, RLNM, or DSD) occurred more frequently in the cohort with BWH low‐T stages (T1 and T2a, 79%) than in the cohort with eighth UICC low‐T stages (T1 and T2, 58%) 19 . In terms of RLNM and DSD, poor outcomes occurred more frequently in the cohort with BWH low‐T stage (63%) than in the cohort with eighth UICC low‐T stage (38%) 19 . However, the current eighth UICC and eighth AJCC staging systems are not commonly used for cSCCs at all skin sites, as previously mentioned.…”

Section: Discussionmentioning

confidence: 97%

“…Meanwhile, conflicting results were reported in a study that compared the prognosis of 604 patients with head and neck cSCC according to the eighth UICC T and BWH staging systems 19 . In both the staging systems, higher T stages were associated with higher rates of LR, RLNM, and DSD 19 . Meanwhile, poor outcomes (LR, RLNM, or DSD) occurred more frequently in the cohort with BWH low‐T stages (T1 and T2a, 79%) than in the cohort with eighth UICC low‐T stages (T1 and T2, 58%) 19 .…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Evaluation of prognostic prediction ability of the novel Japanese risk factor scoring system in a Japanese cohort of resectable cutaneous squamous cell carcinoma: A retrospective cross‐sectional study

Doi

Baba

Katô

et al. 2023

Experimental Dermatology

View full text Add to dashboard Cite

Japanese patients with very high‐risk cutaneous squamous cell carcinomas (cSCCs), based on the National Comprehensive Cancer Network guidelines, have been reported to display a higher cumulative incidence of relapse and disease‐specific death (DSD) than those with high‐risk cSCC. Therefore, prognosis prediction is crucial for Japanese patients with very high‐risk cSCCs. Herein, we aimed to evaluate the prognostic prediction ability of our novel Japanese Risk Factor Scoring Systems (JARF scoring) in a Japanese cohort of cSSC patients. Data of 424 Japanese patients with resectable very high‐risk cSCCs were analysed. We compared the prognostic ability of the following three staging systems: Brigham and Women's Hospital (BWH) tumour staging, number of NCCN very high‐risk factors, and JARF scoring, including recurrent tumour, high‐risk histological features, deep tumour invasion and lymphatic or vascular involvement as risk factors. The prognostic ability of these staging systems was evaluated according to the cumulative incidence of local recurrence (LR), regional lymph node metastasis (RLNM), DSD, and overall survival (OS). When BWH staging was used, high T stage led to significantly poor outcomes only in the cumulative incidence of RLNM (p = 0.01). The presence of very high‐risk NCCN factors led to significantly poor outcomes in terms of RLNM (p = 0.03) and OS (p = 0.02). Meanwhile, a high number of risk factors in the JARF scoring system clearly led to poor outcomes in terms of LR (p = 0.01), RLNM (p < 0.01), DSD (p = 0.03), and OS (p < 0.01). The JARF scoring system may accurately predict the risk of recurrence and death in very high‐risk cSCC patients in Japan.

show abstract

Section: Discussionmentioning

confidence: 91%