Comparison of the EQ-5D-Y-5L, EQ-5D-Y-3L and PedsQL in children and adolescents

Abstract

Background There is an increased use of Patient-Reported Outcome Measures (PROMs) in children and adolescents. The aim of this study was to compare the feasibility, concurrent validity and known-group validity of the EQ-5D-Y-3L (Y-3L), EQ-5D-Y-5L (Y-5L) and PedsQL self-report PROMs. Methods Five hundred and fifty children and adolescents, aged 8–15-years, with acute and chronic health conditions and a general population sample were recruited from schools and hospitals in Cape Town South Africa. All respondents self-completed the Y-5L, PedsQL, Self-Rated Health Question and Y-3L. Feasibility of the measures was determined by comparing the number of missing responses. Convergent validity was assessed by Spearman’s and Intra-class correlations on the corresponding items and summary scores respectively. Known-groups validity across health conditions was assessed across the summary scores of the measures with analysis of variance (ANOVA). Results The Y-3L and Y-5L had a total of 1% and 3.5% missing responses compared to 19% on the PedsQL. Similar items on the PedsQL and Y-3L/Y-5L showed high correlations (> 0.5) and related items showed moderate correlations (0.3). PedsQL total score was moderately and significantly associated with Y-3L and Y-5L level sum and VAS scores. The Y-3L and Y-5L level sum and VAS scores showed significant differences between known health groups whereas the PedsQL only showed differences between those with acute and chronic illness. Conclusion The results of this study show that the Y-3L and Y-5L showed comparable psychometric validity to the PedsQL. When considering the choice between the PedsQL, Y-5L and Y-3L these study results indicate that the EQ-5D-Y instruments (Y-3L and Y-5L) are recommended for studies assessing known-group validity or where missing data should be minimised. The PedsQL generic measure may be preferable in future studies including the general population where a ceiling effect is anticipated. When considering the choice between the Y-5L and the Y-3L there was no systematic difference in the validity between these instruments or between the Y-3L or Y-5L and the PedsQL. Thus, the selection of EQ-5D-Y measures to include in future studies should be guided by the characteristics of the population to be tested.

Fighting to Breathe and Fighting for Health-Related Quality of Life: Measuring the Impact of Being Dependent on Technology for Breathing on the Child and Their Caregiver

“…It was hypothesised that EQ-5D-Y-3L dimensions and LSS would show a moderate-to-high correlation with the PedsQL total score [ 72 ]. It was further anticipated that moderate-to-high correlations would be found between corresponding EQ-5D-Y-3L and PedsQL dimensions/items of mobility and physical functioning; looking after myself and physical functioning; usual activities and physical functioning/social functioning; pain or discomfort and physical functioning; worried, sad, or unhappy and emotional functioning [ 72 ].…”

Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study “PC-COS Children”

“…The PedsQL and EQ-5D families of instruments offer multiple age-specific versions [ 15 , 16 ]. These versions contain questions pertinent to a child's development, and they have been translated into various languages and are used across different medical disciplines.…”

“…ASIAH KASSIM 1 , JENNIFER R. CHEVINSKY 2 , KAREN CHOONG 3 , RAE DUNCAN 4 , SUSANNA ESPOSITO 5 , REBECCA FOSTER 6 , ALLA GUEKHT 7 , ALLISON JAURE 8 , CARRIE MACKENZIE 9 , VIVIENNE MATTHIES-BONN 10 , KAREN MATVIENKO-SIKAR 11 , LORRAINE MCCLOUD 12 , DONNA C MCPARLAND 12 , VICTOR DANIEL MIRON 13 , SRINIVAS MURRHY 14 , SARAH O CONNEL 12 , MARGARET O'HARA 15 , ANNA OGONOWSKA-SLODOWNIK 16 , JANA PAVARE 17 , PAULA ROBERTSON 18 , JEREMY ROSSMAN 19 , OANA SANDULESCU 20 As a result of the Delphi survey, four outcomes met a priori definition for "consensus in" to be included in the core outcome set and eight met the definition of "consensus out" and were excluded from the core outcome set. During the consensus meeting 13 outcomes were discussed: 11 outcomes with no consensus but at least one group voted "in" and two outcomes with no "in" or "out" votes.…”

A Comparison of the Psychometric Properties of the EQ-5D-Y-3L and EQ-5D-Y-5L Using Paediatric Multi-Instrument Comparison (P-MIC) Study Data

“…To overcome the limitations and improve the psychometric performance of the Y-3L, a version with five response levels (EQ-5D-Y-5L, hereon Y-5L) has been developed [8]. The feasibility of the Y-5L has been confirmed in previous studies, however these studies have suggested that further testing of the psychometric properties of the Y-5L is required on different samples and conditions [9][10][11][12].…”