Comparison of the Expression of Cell Adhesion Molecule Markers (E-Cadherin and Syndecan-1) between Young and Older Age Patients with Gastric Carcinoma

Geramizadeh, Bita; Adeli, Omid-Ali; Rahsaz, Marjan; Mokhtari, Maral; Sefidbakht, Sepideh

doi:10.1007/s12029-010-9149-9

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…It has been shown that the diffuse type of gastric cancer was more prevalent in younger than in older patients [ 5 , 7 , 36 – 38 ]. In this study, age under 45 years old was significantly associated with diffuse gastric cancer even when adjusting for gender, tobacco smoking, alcohol consumption and family history of gastric cancer in multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

“…A Mexican study found that polymorphisms of E-cadherin gene was associated with diffuse gastric cancer in young patients [ 37 ]. Furthermore, a study from Korea showed that diffuse GC in young patients had higher proportion of CDH1 alterations and was associated with shorter survival, suggesting that this may contribute to more aggressive clinical course of in young GC patients [ 8 ].Conversely, a study from Iran, did not find any differences in the expression of E-cadherin and Syndecan-1, cell adhesion molecules [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil

et al. 2018

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BackgroundIt has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil.MethodsA total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 > 45 years, considered older group) were evaluated prospectively during a 6 year period.ResultsThe mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival.ConclusionsYounger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil

et al. 2018

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“…Recent studies indicated that the loss of E-CAD expression is associated with a loss of cellular differentiation and increased cellular invasiveness, and it may correlate with muscle involvement and tumor recurrence [20]. Loss of E-CAD is also described in plasmacytoid bladder carcinoma [21], and in other 2 tumor types with aggressive feature, such as diffuse-type gastric cancer and lobular carcinoma of the breast [22,23]. Our data confirm the negative staining of E-CAD in the tumor cells of all the cases, whereas we observed that the dysplastic superficial urothelium strongly expressed E-CAD.…”

Section: Discussionmentioning

confidence: 99%

Plasmacytoid urothelial carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of a case series

et al. 2011

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“…The significance of the expression of Sdc1 and its distribution and localization and association with established prognostic factors and prognostic value have been tested so far in pancreatic cancer [ 14 , 15 ], stomach cancer [ 16 – 18 ], colon cancer [ 19 , 20 ], liver cancer [ 21 ], prostate cancer [ 22 – 24 ], lung cancer [ 25 – 28 ], endometrial cancer [ 29 , 30 ], ovarian cancer [ 31 ], squamous head and neck cancer [ 32 – 36 ], melanoma [ 37 ], laryngeal cancer [ 38 ], cervical cancer [ 39 ], urothelial carcinoma of the bladder [ 40 ], multiple myeloma [ 5 , 41 – 43 ], and breast cancer [ 44 – 46 ] where its overexpression generally means a poor prognosis, although various studies have shown conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases

Miše

Vučić

2018

Analytical Cellular Pathology

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Syndecan-1 (Sdc1) is a transmembrane heparan sulfate proteoglycan, an extracellular matrix receptor involved in intercellular communication, proliferation, angiogenesis, and metastasis. This study determined and compared Sdc1 expression in the tumor cells and stroma of 30 invasive lobular and 30 invasive ductal breast carcinomas (ILCs/IDCs), also in the axillary node metastases of ductal type, and correlated it with clinical and tumor parameters. Sdc1 was expressed in the epithelium of 90% carcinoma of both histological types. Also, it was most frequently expressed in their tumor stroma, but in ILC, stromal expression was negative in 40%. Sdc1 was expressed in 86.7% of the metastatic epithelium of IDC nodal metastases (in even 50% as high expression), while the nodal stroma was negative in 46.7%. Primary IDC showed a negative correlation between epithelial Sdc1 and progesterone receptors (PRs), whereas ILC showed a positive correlation between stromal Sdc1 and histological gradus. In the metastatic epithelium, Sdc1 was negatively correlated with a patient's age, estrogen receptors (ERs), and PRs in the primary tumors, while the stroma of metastases demonstrated a positive correlation with the focus number in primary tumors and a negative correlation with PRs in primary tumors. This research revealed identical overall epithelial Sdc1 expression in both breast carcinomas with no statistically significant difference in its stromal expression and confirmed the role of Sdc1 in the progression of both tumor types and in the development of ductal carcinoma's metastatic potential.

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Comparison of the Expression of Cell Adhesion Molecule Markers (E-Cadherin and Syndecan-1) between Young and Older Age Patients with Gastric Carcinoma

Abstract: Gastric carcinoma in young and old age adults showed no significant difference in respect of the expression of cell adhesion molecule markers. Our result shows that young age alone cannot be predictive of more metastasis and invasion potential.

Cited by 4 publications

References 15 publications

Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil

Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil

Plasmacytoid urothelial carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of a case series

Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases

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