Comparison of the fluorescent treponemal antibody absorption (FTA-ABS) test with the FTA-ABS double staining test for detection of antitreponemal immunoglobulin M in the 19S fraction of human serum

Ozanne, G; d'Halewyn, M A; Larsen, Sandra A.

doi:10.1128/jcm.31.1.102-106.1993

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…The 19S (IgM) FTA-ABS test is usually only available in specialised reference laboratories [32]. The reported sensitivity of the 19S FTA-ABS test in clinical CS cases is 72-77% [3][4][5][6], with a specificity of 100% [5][6][7]. One to two percent (1-2%) of asymptomatic children at risk were found to be positive for IgM [3,5,6].…”

Section: Laboratory Diagnosismentioning

confidence: 99%

A review of diagnostic tests for congenital syphilis in newborns

Herremans

Kortbeek

Notermans

2010

Eur J Clin Microbiol Infect Dis

108

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Congenital syphilis (CS) can occur when a mother is inadequately treated or not treated at all for an active Treponema pallidum infection. Symptoms of CS are often subtle and non-specific, and it is estimated that up to 60% of affected infants are asymptomatic at birth, making the diagnosis dependent on laboratory findings. Despite decades of experience with CS, problems still arise in its diagnosis because laboratory test results for children at risk for CS can be inconclusive and no single diagnostic test can be used to diagnose CS. The development of diagnostic tests such as enzyme immunoassays, immunoblotting and polymerase chain reaction (PCR) has increased the sensitivity and specificity of diagnoses, but the detection of specific IgM is currently the most sensitive serological method, and the presence of specific IgM should be considered as evidence of a congenital T. pallidum infection. Suspected cases can also be confirmed or excluded by serial post-partum tests of antibody kinetics. The authors note strongly that it is considered unethical not to treat a baby at risk of contracting CS, even without a definitive diagnosis. In this review, we describe the various microbiological methods-and their shortcomings-used in the laboratory diagnosis of CS.

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