Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes

Fujihara, Kazuya; Suzuki, Hiroaki; Sato, Akira; Ishizu, Tomoko; Kodama, Satoru; Heianza, Yoriko; Saito, Kazumi; Iwasaki, Hitoshi; Kobayashi, Kazuto; Yatoh, Shigeru; Takahashi, Akimitsu; Yahagi, Naoya; Sone, Hirohito; Shimano, Hitoshi

doi:10.5551/jat.20487

Cited by 27 publications

(26 citation statements)

References 36 publications

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“…The carotid IMT was measured as the stiffness and show the structural and functional properties of the arterial wall 10,11) . Another standard technique that is used is carotid ultrasonography, by which the intima-media wall thickness (IMT) of the artery, which shows the structural change of arterial wall, can be evaluated [12][13][14][15][16][17][18] . Previous studies suggested that the risk factors associated with arterial stiffness and wall thickness were not identical [19][20][21] .…”

Section: Assessment Of Arterial Wall Thicknessmentioning

confidence: 99%

Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus

Takahara

Katakami

Osonoi

et al. 2015

JAT

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Aim:We statistically investigated whether the impact of cardiovascular risk factors on arterial stiffness would be different from that on arterial wall thickness. Methods: We analyzed 1648 Japanese type 2 diabetic patients. Arterial stiffness was evaluated by pulse wave verbosity (PWV) and wall thickness was assessed with carotid intima-media thickness (IMT) by ultrasonography. We developed a common regression model to PWV and IMT by extending the linear mixed model and statistically detected the difference in the impact of cardiovascular risk factors between the two indices. Results: There was a significant correlation between PWV and IMT (r 0.365, p 0.001). Sex, diabetic duration, hemoglobin A1c levels, and the presence of retinopathy and cardiovascular disease were comparable independent risk factors for elevated PWV and IMT. On the other hand, the impact of age, systolic blood pressure, and low-and high-density lipoprotein cholesterol levels were significantly different between the two measurements (all p 0.05). Cholesterol levels were significantly associated with IMT but not with PWV. Age and systolic blood pressure had a significant impact on both measurements, but the impact on PWV was significantly greater than that on IMT. Indeed, patients with low IMT but with advanced age and high systolic pressure had high PWV, whereas patients with low PWV but with impaired cholesterol levels had high IMT. Conclusion:The extended linear mixed model statistically confirmed that the impact of cardiovascular risk factors on elevated PWV and IMT were not identical in Japanese patients with type 2 diabetes mellitus. J Atheroscler Thromb, 2015; 22: 971-980.

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Section: Assessment Of Arterial Wall Thicknessmentioning

confidence: 99%

Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus

Takahara

Katakami

Osonoi

et al. 2015

JAT

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“…A meta-analysis of eight randomized 2012 88) . Fujihara et al reported that combining several risk stratification scores with the carotid max IMT improved the prediction of coronary artery stenosis using the C statistics and NRIs in asymptomatic patients with type 2 diabetes 89) . Further studies are warranted to clarify whether the addition of carotid IMT to those risk stratifications predicts future cardiovascular events in the general population of Japan.…”

Section: Is the Carotid Imt Useful For Cvd Riskmentioning

confidence: 99%

Carotid Intima-Media Thickness for Atherosclerosis

Nezu

Hosomi

Aoki

et al. 2016

J Atheroscler Thromb

262

201

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“…7 Patients with significant mitral or aortic valvular heart disease, a rhythm other than normal sinus rhythm, or LVEF <50% were also excluded.…”

Section: Editorial P 1687mentioning

confidence: 99%

Subendocardial Systolic Dysfunction in Asymptomatic Normotensive Diabetic Patients

Enomoto

Ishizu

Seo

et al. 2015

Circ J

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Background: It remains uncertain whether diabetes itself causes specific echocardiographic features of myocardial morphology and function in the absence of hypertension or ischemic heart disease. The purpose of the present study was to determine the characteristics of pure diabetic cardiomyopathy-related echocardiographic morphology and function using layer-by-layer evaluation with myocardial strain echocardiography. Methods and Results:We enrolled 104 patients with poorly controlled type 2 diabetes mellitus (mean HbA1c level, 10%) with (n=74) or without (n=40) hypertension and 24 age-and sex-matched healthy volunteers. Patients with coronary artery stenosis or structural heart disease were excluded. Myocardial layer-specific strain was analyzed by speckle tracking echocardiography. Compared with the healthy control group, the normotensive diabetes group showed no significant difference in ejection fraction, left ventricular mass index, diastolic properties, left atrial volume index, or B-type natriuretic protein (BNP) level, but global longitudinal strain and subendocardial radial strain were significantly deteriorated. The deterioration of longitudinal strain correlated with body mass index (R=0.49, P<0.01) and blood pressure (R=0.36, P<0.01) in the normotensive diabetes group. Conclusions:Deterioration of left ventricular longitudinal shortening accompanied by decreased subendocardial wall thickening are the characteristic functional abnormalities of diabetic cardiomyopathy in patients without hypertrophy, diastolic dysfunction, or elevated BNP. Obesity and blood pressure may also play important roles in this strain abnormality in asymptomatic patients with type 2 diabetes. (Circ J 2015; 79: 1749 -1755

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Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes

Cited by 27 publications

References 36 publications

Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus

Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus

Carotid Intima-Media Thickness for Atherosclerosis

Subendocardial Systolic Dysfunction in Asymptomatic Normotensive Diabetic Patients

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