Comparison of the growth‐promoting effects of testosterone and 7‐α‐methyl‐19‐nor‐testosterone (MENT) on the prostate and levator ani muscle of LPB‐tag transgenic mice

Abstract

MENT is more potent than T in maintaining or stimulating prostate, seminal vesicle, and LAM. Using doses that resulted in comparable stimulation of the levator ani muscle, MENT had similar effect on prostate weight, but increased DNA/mg prostate less than T in this transgenic mouse model of prostate cancer.

The Potential Use of Hormone-Based Therapeutics for the Treatment of Alzheimers Disease

“…Compounds in this class have shown good tissue specificity and are not substrates for 5 -reductase, the enzyme that converts testosterone to the more potent androgen, DHT. SARMs that are not 5 -reductase substrates and thus do not form DHT or DHTlike derivatives have relatively low androgen action in prostate since prostate growth depends largely on the actions of DHT rather than testosterone [221][222][223][224][225][226][227]. There are several promising synthetic androgens with varied affinity for AR and androgenic activity, including 7 -methyl-19-nortestosterone, commonly called MENT [226][227][228].…”

“…There are several promising synthetic androgens with varied affinity for AR and androgenic activity, including 7 -methyl-19-nortestosterone, commonly called MENT [226][227][228]. MENT is promising because it shows low androgen activity in prostate but is more potent than testosterone in other peripheral androgen-responsive tissues including bone and muscle [226,227,229]. Although not a substrate for 5 -reductase, MENT is a substrate for aromatase and thus, like testosterone, generates some estradiol.…”

“…SARMs that are not 5 -reductase substrates and thus do not form DHT or DHTlike derivatives have relatively low androgen action in prostate since prostate growth depends largely on the actions of DHT rather than testosterone [221][222][223][224][225][226][227]. There are several promising synthetic androgens with varied affinity for AR and androgenic activity, including 7 -methyl-19-nortestosterone, commonly called MENT [226][227][228]. MENT is promising because it shows low androgen activity in prostate but is more potent than testosterone in other peripheral androgen-responsive tissues including bone and muscle [226,227,229].…”

Gender-specific postnatal demethylation and establishment of epigenetic memory

“…Mice were anesthetized and either sham-operated or castrated by removal of the gonads at the age of 3 or 20 wk. Testosterone (5 mg/mL) or vehicle alone was dissolved as described (Shao et al 2006) and then injected into an osmotic pump (Alzet, model 2004) that was incubated in saline for 48 h at 37°C and then implanted subcutaneously into castrated males or females. For long-term testosterone administration, the pumps were replaced every 28 d. All animal experiments were performed in accordance with the guidelines of the Institutional Committee for the Use of Animals for Research.…”

The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies

“…SARMS derived from the steroid structure, have been shown to have low androgenic activity in the prostate but equivalent or greater potency than testosterone in bone and muscle offering benefits for osteoporosis and sarcopenia (Venken et al, 2005) (Shao et al, 2006). Neuroprotective efficacy is now being explored.…”