Comparison of the haemodynamic actions of neuropeptide Y, angiotensin II and noradrenaline in anaesthetised cats

Alpha adrenergic receptors are involved in the contractile activity of neuropeptide Y in the porcine isolated ovarian artery

“…The present study revealed that NPY caused an increase in blood pressure in the isolated ovarian artery obtained from the immature and mature pigs. Similar vasocontractile effect of NPY treatment was observed in vitro in the rabbit ovarian artery (Yao et al, 1996) as well as dog, cat and pig spleen arteries (Lundberg et al, 1984; Corder et al, 1987;Pernow and Lundberg, 1988), human and sheep coronary arteries (FrancoCereceda, 1989;Kwan et al, 1990) and in vivo in vessels of rabbit (Jorgesen and Sejresen, 1990), rat (Zukowska-Grojec et al, 1986), cat (Corder et al, 1986), dog (Suzuki et al, 1988) and pig . Administration of PYX-1, a nonispecific antagonist of NPY receptors alone as well as administration of NPY into PYX-1 pre-treated vessels did not cause any significant changes (P > 0.05) in blood pressure in all the groups examined as compared to the levels determined before the peptide administration (Figure 2).…”

“…In experiments in vitro performed on dog (Chiba, 2001) and rabbit (Abel and Han, 1989) cerebral arteries, dog (Corder et al, 1987), cat (Lundberg et al, 1985) and pig (Roberts et al, 1999) spleen arteries, human (Franco-Cereceda, 1989), dog (Macho et al, 1989) and sheep (Kwan et al, 1990) coronary arteries, pig (Martling et al, 1990) and rabbit (Obara et al, 1989) pulmonary and bronchial arteries, human (Pernow and Lundberg, 1988) muscular arteries, and pig (Markiewicz et al, 1998a,b) ovarian artery it has been observed that NPY acts as a vasoconstrictor. The vasospastic effect of NPY has been also observed in experiments in vivo performed on rat (Cortes et al, 1999) and pig (Malmstrom, 2000) mesenteric arteries, rat renal interlobar arteries (Chen et al, 1997), dog spleen vessels (Yang and Chiba, 2000), rabbit ovarian ar-tery (Jorgesen and Sejresen, 1990) and cat renal and femoral arteries (Corder et al, 1986). Wąsowicz et al (1999) have shown, that the number of NPY-IR fibres and the concentration of NPY undergoes changes during the course of the oestrous cycle in the pig oviduct and uterus.…”

The actions of the peptides, neuropeptide Y and peptide YY, on the vascular and capsular smooth muscle of the isolated, blood‐perfused spleen of the dog

“…Bolus administration of NPY has been shown to elicit a systemic pressor effect which is resistant to adrenoceptor blockade Dahlof et al, 1985;Corder et al, 1986). This effect is due almost entirely to an increase in peripheral vascular resistance (Corder et al, 1986).…”

“…This effect is due almost entirely to an increase in peripheral vascular resistance (Corder et al, 1986). However, the importance of individual tissue sensitivity to NPY in producing changes in regional vascular resistance has not been adequately investigated.…”

Neuropeptide Y: An overview

“…Forearm Intrarenal i.v. Pernow et al, 1987Smyth et al, 1988Corder et al, 1986Millar et al, 1988 (continued) propionyl NPY binding in rabbit aortic membranes. However, in rat vas deferens, PYY is 30-fold more potent than NPY in inhibiting field stimulation-induced contractions.…”