Comparison of the hydrophilicity of water-soluble poly(2-alkyl-2-oxazoline)s, poly(2-alkyl-2-oxazine)s and poly(2,4-dialkyl-2-oxazoline)s

Mint, Kelly; Morrow, Joshua P.; Warne, Nicole M.; He, Xie; Pizzi, David; Shah, Shaffiq Zainal Osman; Pierens, Gregory K.; Fletcher, Nicholas L.; Bell, Craig A.; Thurecht, Kristofer J.; Kempe, Kristian

doi:10.1039/d4py00332b

Polym. Chem.

2024

DOI: 10.1039/d4py00332b

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Comparison of the hydrophilicity of water-soluble poly(2-alkyl-2-oxazoline)s, poly(2-alkyl-2-oxazine)s and poly(2,4-dialkyl-2-oxazoline)s

Kelly Mint,

Joshua P. Morrow,

Nicole M. Warne

et al.

Abstract: Poly(cyclic imino ether)s (PCIEs) including poly(2-alkyl-2-oxazoline) (POx), poly(2-alkyl-2-oxazine) (POz) and poly(2,4-dialkyl-2-oxazoline) (PdOx) are a rapidly emerging polymer class for use in biomedical and therapeutic applications due to the biocompatibility and...

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Cited by 4 publications

References 75 publications

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Bottlebrush Hydrogels with Hidden Length: Super‐Swelling and Mechanically Robust

Wang,

Vashahi,

Moutsios

et al. 2024

Adv Funct Materials

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Hydrogels are explored for applications in agriculture, water purification, and biomedicine, leveraging softness, elasticity, and high water uptake. However, hydrogels are notoriously brittle, especially at high water content. This shortcoming puts the improvement of hydrogel mechanics at the forefront of current research. Yet modern strategies for enhancing gel resilience come at the expense of softness and swelling. This problem is addressed using bottlebrush networks with disentangled strands and hidden length reservoirs, which synergistically enhance gel swelling and robustness while maintaining their softness. Implementing a facile one‐pot synthesis of single‐stranded bottlebrush networks with a relatively hydrophobic poly(2‐hydroxyethyl methacrylate) (PHEMA) backbone and hydrophilic poly(2‐methyl‐2‐oxazoline) (PMOx) side chains, hydrogels are prepared with a modulus below <1 kPa and swelling ratios up to 125 that can withstand up to 10‐fold extension.

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Bottlebrush Hydrogels with Hidden Length: Super‐Swelling and Mechanically Robust

Wang,

Vashahi,

Moutsios

et al. 2024

Adv Funct Materials

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Impact of Drug Conjugation Site and Corona Chemistry on the Therapeutic Activity of Polymer Nanorod – Drug Conjugates

Warne,

Nowell,

Tran

et al. 2024

Adv Healthcare Materials

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Biocompatible rod‐shaped nanoparticles of controlled length can be produced through the heat‐induced “living” seeded crystallization‐driven self‐assembly (CDSA) of poly(2‐isopropyl‐2‐oxazoline)‐containing block copolymers. With a hydrophilic poly(2‐methyl‐2‐oxazine) or poly(2‐methyl‐2‐oxazoline) corona, these nanorods have proven non‐cytotoxic, non‐hemolytic, and ideal for use as a polymer‐based drug delivery system. This study demonstrates a facile, one‐pot method for the synthesis of mycophenolic acid (MPA)‐conjugated block copolymer “unimers” for use in seeded CDSA. Through altering block order during sequential monomer addition cationic ring‐opening polymerization (CROP), MPA is conjugated to either the chain end of the core‐forming or corona‐forming block. This allows bioactive polymer nanorods to be prepared with MPA positioned at either the periphery of the corona, or at the core‐corona interface of the nanorod formed during seeded CDSA. In vitro, these nanorods arrest growth in human T and B lymphocytes, with reduced effect in “off‐target” monocytes when compared with unconjugated MPA. Furthermore, the conjugation of MPA to the core‐corona interface of the nanorods leads to a slower release and reduced cytostatic effect. This study offers a robust investigation into the effect of steric hindrance and corona chemistry on the therapeutic potential of drug‐conjugated CDSA nanorods and demonstrates the potential of poly(2‐oxazoline)/poly(2‐oxazine)‐based CDSA nanomaterials as effective drug delivery platforms.

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Expanding the poly(2-oxazoline) block copolymer possibilities through nitroxide mediated polymerisation

Lefley,

Becer

2024

Polym. Chem.

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Comparison of the hydrophilicity of water-soluble poly(2-alkyl-2-oxazoline)s, poly(2-alkyl-2-oxazine)s and poly(2,4-dialkyl-2-oxazoline)s

Abstract: Poly(cyclic imino ether)s (PCIEs) including poly(2-alkyl-2-oxazoline) (POx), poly(2-alkyl-2-oxazine) (POz) and poly(2,4-dialkyl-2-oxazoline) (PdOx) are a rapidly emerging polymer class for use in biomedical and therapeutic applications due to the biocompatibility and...

Cited by 4 publications

References 75 publications

Bottlebrush Hydrogels with Hidden Length: Super‐Swelling and Mechanically Robust

Bottlebrush Hydrogels with Hidden Length: Super‐Swelling and Mechanically Robust

Impact of Drug Conjugation Site and Corona Chemistry on the Therapeutic Activity of Polymer Nanorod – Drug Conjugates

Expanding the poly(2-oxazoline) block copolymer possibilities through nitroxide mediated polymerisation

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