Comparison of the immune response to sheep erythrocytes, tetanus toxoid and endotoxin in different strains of mice

Borel, J. F.

doi:10.1007/bf01965231

Cited by 11 publications

(4 citation statements)

References 30 publications

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“…The assay of localized haemolysis in gel (LHG), used to detect both direct and indirect plaque-forming cells (PFC), was described previously [2]. The same developing serum as indicated in the above reference was used for detection of the IgG2a PFC.…”

Section: Methodsmentioning

confidence: 99%

Biological effects of cyclosporin A: A new antilymphocytic agent

Borel¹,

Feurer²,

Gubler³

et al. 1994

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The fungus metabolite cyclosporin A is a small peptide acting as a novel antilymphocytic agent. It strongly depressed appearance of both direct and indirect plaqueforming cells and produced a clear dose-dependent inhibition of haemagglutinin formation in mice upon oral administration. Skin graft rejection in mice and graft-versus-host disease in mice and rats were considerably delayed by cyclosporin A which also prevented the occurrence of paralysis in rats with experimental allergic encephalomyelitis. This compound was not only highly effective in preventing development of Freund's adjuvant arthritis, but in addition improved the symptoms in rats with established arthritis, although it is inactive in acute inflammation. This new agent contrasts with other immunosuppressives and cytostatic drugs in its weak myelotoxicity. Experimental evidence suggests that cyclosporin A, rather than being cytostatic or lympholytic, affects an early stage of mitogenic triggering of the immunocompetent lymphoid cell.

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Section: Methodsmentioning

confidence: 99%

Biological effects of cyclosporin A: A new antilymphocytic agent

Borel¹,

Feurer²,

Gubler³

et al. 1994

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Self Cite

196

166

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show abstract

“…The assay of localized haemolysis in gel (LHG), use,a to detect both direct and indirect plaque-forming cells (PFC), was described previously [2]. The same developing serum as indicated in the above reference was used for detection of the IgG2a PFC.…”

Section: Methodsmentioning

confidence: 99%

Biological effects of cyclosporin A: A new antilymphocytic agent

Borel¹,

Feurer²,

Gubler³

et al. 1976

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1,329

246

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The fungus metabolite cyclosporin A is a small peptide acting as a novel antilymphocytic agent. It strongly depressed appearance of both direct and indirect plaque-forming cells and produced a clear dose-dependent inhibition of haemagglutinin formation in mice upon oral administration. Skin graft rejection in mice and graft-versus-host disease in mice and rats were considerably delayed by cycloporin A which also prevented the occurrence of paralysis in rats with experimental allergic encephalomyelitis. This compound was not only highly effective in preventing development of Freund's adjuvant arthritis, but in addition improved the symptoms in rats with established arthritis, although it is inactive in acute inflammation. This new agent contrasts with other immunosuppressives and cytostatic drugs in its weak myelotoxicity. Experimental evidence suggests that cyclosporin A, rather than being cytostatic or lympholytic, affects an early stage of mitogenic triggering of the immunocompetent lymphoid cell.

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“…The direct and indirect PFC from the spleen were determined.on day 7 after imrnunisation as previously described [7,8].…”

Section: Assay For Haemolytic Plaque-formlng Cells (Pfc)mentioning

confidence: 99%