Comparison of the Immune Responses to COVID-19 Vaccines in Bangladeshi Population

Sarker, Protim; Akhtar, Evana; Kuddusi, Rakib Ullah; Alam, Mohammad Mamun; Haq, Md. Ahsanul; Hosen, Md. Biplob; Chanda, Bikash Chandra; Haque, Fazlul; Alam, Muntasir; Razzaque, Abdur; Rahman, Mustafizur; Ahmed, Faruque; Kibria, Md Golam; Islam, Mohammed Zahirul; Ahmed, Shehlina; Raqib, Rubhana

doi:10.3390/vaccines10091498

Cited by 13 publications

(18 citation statements)

References 54 publications

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“…Nevertheless, differences in immune response regarding different type of vaccines could already be observed, which might have in influence on the course of breakthrough infections. 16 COVID-19 vaccination involves numerous immune responses such as activation of lymphocytes and producing of neutralising antibodies. However, other pathways such as kinetics involved in cytokines and their receptors, and stimulation of non-T cell responses remain poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases

et al. 2023

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ObjectiveTo analyse the clinical profile of SARS-CoV-2 breakthrough infections in at least double-vaccinated patients with inflammatory rheumatic diseases (IRDs).MethodsData from the physician-reported German COVID-19-IRD registry collected between February 2021 and July 2022 were analysed. SARS-CoV-2 cases were stratified according to patients’ vaccination status as being not vaccinated, double-vaccinated or triple-vaccinated prior to SARS-CoV-2 infection and descriptively compared. Independent associations between demographic and disease features and outcome of breakthrough infections were estimated by multivariable logistic regression.ResultsIn total, 2314 cases were included in the analysis (unvaccinated n=923, double-vaccinated n=551, triple-vaccinated n=803, quadruple-vaccinated n=37). SARS-CoV-2 infections occurred after a median of 151 (range 14–347) days in patients being double-vaccinated, and after 88 (range 14–270) days in those with a third vaccination. Hospitalisation was required in 15% of unvaccinated, 8% of double-vaccinated and 3% of triple-vaccinated/quadruple-vaccinated patients (p<0.001). Mortality was 2% in unvaccinated, 1.8% in the double-vaccinated and 0.6% in triple-vaccinated patients. Compared with unvaccinated patients, double-vaccinated (OR 0.43, 95% CI 0.29 to 0.62) and triple-vaccinated (OR 0.13, 95% CI 0.08 to 0.21) patients showed a significant lower risk of COVID-19-related hospitalisation. Using multivariable analysis, the third vaccination was significantly associated with a lower risk for COVID-19-related death (OR 0.26; 95% CI 0.01 to 0.73).ConclusionsOur cross-sectional data of COVID-19 infections in patients with IRD showed a significant reduction of hospitalisation due to infection in double-vaccinated or triple-vaccinated patients compared with those without vaccination and even a significant reduction of COVID-19-related deaths in triple-vaccinated patients. These data strongly support the beneficial effect of COVID-19 vaccination in patients with IRD.Trial registration numberEuDRACT 2020-001958-21.

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Section: Discussionmentioning

confidence: 99%

Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases

et al. 2023

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“…This result is consistent with findings from several immune response studies on COVID-19 vaccines in human populations ( 27 – 31 ). In a recently conducted community-based study in Bangladesh, mRNA vaccine recipients showed higher antibody response than adenovector and killed whole-virus vaccine recipients ( 24 ). The S protein of SARS-CoV-2 is used as the immunogen in the Pfizer/Comirnaty, Moderna/Spikevax, and AstraZeneca/Covishield vaccines to generate anti-S antibodies that block the S protein’s binding to host cell ( 32 – 34 ).…”

Section: Discussionmentioning

confidence: 99%

“…A strong correlation between past SARS-CoV-2 infection and higher anti-S antibodies was also seen. Recently, in five major divisions of Bangladesh, persons with previous SARS-CoV-2 infection were shown to have higher post-vaccine immunological responses compared to non-infected individuals ( 24 ). In another study in the Bangladeshi population, after immunization, those with a record of SARS-CoV-2 infection had six times higher antibody titers than those without a history of infection ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

“…Both assays were carried out using the Roche Cobas-e601 immunoassay analyzer (Roche Diagnostics GmbH, Mannheim) following the manufacturer’s guidelines. In antibody detection, ECLIA can be compatible with the plaque reduction neutralization test (PRNT), microneutralization test (MNT), Pseudovirus Neutralization Assay (PNA) as revealed in the previous studies ( 24 – 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…The socioeconomic effects of COVID-19 on Bangladeshi migrant workers have been assessed in few studies ( 9 , 21 ). Few other researchers have reported the immunological response to SARS-CoV-2 infection and the COVID-19 vaccination in Bangladeshi population ( 22 – 24 ). However, there is no report on seroconversion or post-vaccine COVID-19 antibody response in migrant workers.…”

Section: Introductionmentioning

confidence: 99%

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Antibody response to different COVID-19 vaccines among the migrant workers of Bangladesh

Hossain

Sarker²,

Raqib³

et al. 2023

Front. Immunol.

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BackgroundDue to the ongoing COVID-19 pandemic, various host countries such as Singapore, imposed entry requirements for migrant workers including pre-departure COVID-19 seroconversion proof. To combat COVID-19 worldwide, several vaccines have acquired conditional approval. This study sought to assess antibody levels after immunization with different COVID-19 vaccines among the migrant workers of Bangladesh.MethodsVenous blood samples were collected from migrant workers who were vaccinated with different COVID-19 vaccines (n=675). Antibodies to SARS-CoV-2 spike protein (S) and nucleocapsid protein (N) were determined using Roche Elecsys® Anti-SARS-CoV-2 S and N immunoassay, respectively.ResultsAll participants receiving COVID-19 vaccines showed antibodies to S-protein, while 91.36% were positive for N-specific antibodies. The highest anti-S antibody titers were found among the workers who completed booster doses (13327 U/mL), received mRNA vaccines Moderna/Spikevax (9459 U/mL) or Pfizer-BioNTech/Comirnaty (9181 U/mL), and reported SARS-CoV-2 infection in the last six months (8849 U/mL). The median anti-S antibody titers in the first month since the last vaccination was 8184 U/mL, which declined to 5094 U/mL at the end of six months. A strong correlation of anti-S antibodies was found with past SARS-CoV-2 infection (p < 0.001) and the type of vaccines received (p <0.001) in the workers.ConclusionBangladeshi migrant workers receiving booster doses of vaccine, vaccinated with mRNA vaccines, and having past SARS-CoV-2 infection, mounted higher antibody responses. However, antibody levels waned with time. These findings suggest a need for further booster doses, preferably with mRNA vaccines for migrant workers before reaching host countries.

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Seroprevalence of SARS-CoV-2 in wet market workers in Dhaka, Bangladesh in 2022

Rahman,

Alam,

Sarkar

et al. 2025

IJID Regions

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Comparison of the Immune Responses to COVID-19 Vaccines in Bangladeshi Population

Cited by 13 publications

References 54 publications

Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases

Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases

Antibody response to different COVID-19 vaccines among the migrant workers of Bangladesh

Seroprevalence of SARS-CoV-2 in wet market workers in Dhaka, Bangladesh in 2022

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