Comparison of the impact of propofol versus sevoflurane on early postoperative recovery in living donors after laparoscopic donor nephrectomy: a prospective randomized controlled study

Han, Sangbin; Park, Jaesik; Hong, Sang Hyun; Lim, Soojin; Park, Yong Hyun; Chae, Min Suk

doi:10.1186/s12871-020-01190-9

Cited by 11 publications

(6 citation statements)

References 44 publications

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“…TIVA is particularly useful in some situations where inhalational anesthesia is contraindicated or may interfere with the operation. Several recent studies also showed that TIVA leads to better outcomes and even relieves postoperative pain compared with inhalant anesthesia [ 7 , 8 ]. Nevertheless, many anesthesiologists prefer volatile anesthesia (VA) because it is relatively easy to use, especially in short-duration surgeries.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Randomized Comparison of Postoperative Pain and Complications after Thyroidectomy under Different Anesthetic Techniques: Volatile Anesthesia versus Total Intravenous Anesthesia

Kim

Choi

et al. 2021

Pain Research and Management

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While the postoperative outcome is favorable, post-thyroidectomy pain is considerable. Reducing the postoperative acute pain, therefore, is considered important. This study investigated whether the pain intensity and need for rescue analgesics during the immediate postoperative period after thyroidectomy differ according to the methods of anesthesia. Seventy-two patients undergoing total thyroidectomy under general anesthesia were examined. Patients were randomly assigned to undergo either total intravenous anesthesia with remifentanil and propofol (TIVA, n = 35) or propofol induction and maintenance with desflurane and nitrous oxide (volatile anesthesia [VA], n = 37). The mean administered dose of remifentanil was 1977.7 ± 722.5 μg in the TIVA group, which was approximately 0.268 ± 0.118 μg/min/kg during surgery. Pain scores based on a numeric rating scale (NRS) and the need for rescue analgesics were compared between groups at the postoperative anesthetic care unit (PACU). The immediate postoperative NRS values of the TIVA and VA groups were 5.7 ± 1.7 and 4.7 ± 2.3, respectively ( P = 0.034). Postoperative morphine equianalgesic doses in the PACU were higher in the TIVA group than in the VA group (16.7 ± 3.8 mg vs. 14.1 ± 5.9 mg, P = 0.027). The incidence of immediate postanesthetic complications did not differ significantly between groups. In conclusion, more rescue analgesics were required in the TIVA group than in the VA group to adequately manage postoperative pain while staying in the PACU after thyroidectomy.

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Section: Introductionmentioning

confidence: 99%

A Prospective Randomized Comparison of Postoperative Pain and Complications after Thyroidectomy under Different Anesthetic Techniques: Volatile Anesthesia versus Total Intravenous Anesthesia

Kim

Choi

et al. 2021

Pain Research and Management

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“…Propofol produces less postoperative nausea and vomiting, a better sense of well-being, and a better quality of postoperative recovery. 26 - 28 According to the previous studies, the emotional state, which was evaluated using psychometric test, was significantly better after propofol-based anesthesia than sevoflurane-based anesthesia, 27 and the quality of recovery, including physical comfort, emotional state, physical independence, psychological support, and pain, was also significantly greater in the propofol group than in the sevoflurane group. 28 Second, although the pathophysiology and mechanism of POD have not yet been clearly determined, anti-inflammatory and anti-apoptotic properties of propofol may contribute to the lower incidence of POD compared with sevoflurane.…”

Section: Discussionmentioning

confidence: 93%

Association Between Anesthetics and Postoperative Delirium in Elderly Patients Undergoing Spine Surgery: Propofol Versus Sevoflurane

Chang

Min

Kim

et al. 2022

Global Spine Journal

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Study designs Retrospective Observational Study Objectives: To compare the incidence of POD after propofol- and sevoflurane-based anesthesia in elderly patients undergoing spine surgery. Methods In this study, the medical records of elderly patients ≥ 65 years of age who underwent spine surgery under total intravenous anesthesia with propofol or inhalational anesthesia with sevoflurane were reviewed. The primary outcome was the incidence of POD after propofol- and sevoflurane-based anesthesia. Secondary outcomes included postoperative 30-day complications, length of postoperative hospital stay, associations of patient characteristics, and surgery- and anesthesia-related data with the development of POD, and associations of anesthetics with clinical outcomes such as postoperative 30-day complications, and length of postoperative hospital stay. Results Of the 281 patients, POD occurred in 29 patients (10.3%). POD occurred more frequently in the sevoflurane group than in the propofol group (15.7% vs. 5.0%, respectively; P=.003). The multivariable logistic regression analysis showed that sevoflurane-based anesthesia was associated with an increased risk of POD compared with propofol-based anesthesia (odds ratio [OR], 4.120; 95% confidence interval [CI], 1.549−10.954; P = .005), whereas anesthetics were not associated with postoperative 30-day complications and the length of postoperative hospital stay. Older age (OR, 1.242 CI, 1.130−1.366; P < .001) and higher mean pain score at postoperative day 1 (OR, 1.338 CI, 1.056−1.696; P = .016) were also associated with an increased risk of POD. Conclusions Propofol-based anesthesia was associated with a lower incidence of POD than sevoflurane-based anesthesia in elderly patients after spine surgery.

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“…Another study showed that propofol reduces anxiety more than midazolam (25). This could be explained by a unique effect of propofol on the sense of well-being (27,28). The increase in dopamine levels in the nucleus accumbens is associated with the feeling of wellbeing in propofol patients (a phenomenon seen in drug abusers with pleasure-seeking behavior), (29).…”

Section: Discussionmentioning

confidence: 99%

Post-traumatic stress and awareness in patient with traumatic lower limb surgery by neuraxial anesthesia: A randomized clinical trial

Hashemian¹,

Zandrahimi²,

Mirafzal³

et al. 2023

Arch Psych Psych

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Aim of the studyAnesthesia decreases brain cognitive function, memory and pain, and also leads to the loss of consciousness. In this study, midazolam and propofol-sedated trauma patients undergoing lower limb surgery were evaluated for stress levels after neuraxial anesthesia.Subject or material and methodsThis double-blind randomized clinical trial was conducted on patients with lower extremity fractures due to trauma, who were candidates of elective lower extremity orthopedic surgery. Patients were randomly divided into two groups of propofol-sedated patients (n=110) and midazolam-sedated patients (n=110) after neuraxial anesthesia. Then, all patients underwent spinal anesthesia using 3 ml of 0.5% bupivacaine (3 mg/kg). Propofol (25-75 µg/kg/minute) was infused, and 1-2 mg of midazolam was injected PRN until patients reached the score of 3 on the Modified Observers' Assessment of Alertness/ Sedation Scale (MOAA/S).ResultsPreoperative sedation/alertness scores of patients in the two groups did not differ significantly from one another. Penetrating memories in the midazolam group was higher than the propofol group (P<0.05). Personal relationship problem was more significant in the midazolam group than the propofol group (P<0.05). Inability in controlling emotional feelings was higher in the midazolam group compared to the propofol group (P<0.001).DiscussionOur findings indicated that a sub-hypnotic dose of propofol provided superior sedation and amnesia compared to midazolam. Aspects of stress, including penetrating memories, personal relationship problems, inability to control emotional feelings, and lack of depression during spinal anesthesia were better managed by propofol compared to midazolam.ConclusionsPropofol infusion was better in decreasing stress levels after surgery compared to midazolam.

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Comparison of the impact of propofol versus sevoflurane on early postoperative recovery in living donors after laparoscopic donor nephrectomy: a prospective randomized controlled study

Cited by 11 publications

References 44 publications

A Prospective Randomized Comparison of Postoperative Pain and Complications after Thyroidectomy under Different Anesthetic Techniques: Volatile Anesthesia versus Total Intravenous Anesthesia

A Prospective Randomized Comparison of Postoperative Pain and Complications after Thyroidectomy under Different Anesthetic Techniques: Volatile Anesthesia versus Total Intravenous Anesthesia

Association Between Anesthetics and Postoperative Delirium in Elderly Patients Undergoing Spine Surgery: Propofol Versus Sevoflurane

Post-traumatic stress and awareness in patient with traumatic lower limb surgery by neuraxial anesthesia: A randomized clinical trial

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