Comparison of the incidence of new malignancies in diabetic patients in urban and rural populations in Poland in the years 2008–2014 based on the database of the National Health Fund

Abstract

A b s t r a c tIntroduction: Many epidemiological studies show a correlation between the risk of cancer and type 2 diabetes mellitus in various populations. Material and methods: The material was obtained from the database of the National Health Fund. This publication presents a comparison of the incidence of new malignancies in rural and urban populations of diabetic patients in Poland based on the database of the National Health Fund for the period between 1. 05.2008 and 30.09.2014. Results: Comparison of the mean incidence of selected malignancies in diabetic patients in the population analysed indicated significant differences between the incidence rate in the urban and rural populations (p < 0.001). The mean incidence of gastric cancer, colorectal cancer, kidney cancer, brain tumours and leukaemia in both sexes was significantly higher in rural areas compared to urban. The mean incidence of oesophageal cancer and pancreatic cancer in females was significantly higher among in the urban population compared to the rural areas (p < 0.001). No differences in the incidence rate of these neoplasms were observed in men (p > 0.05). Conclusions: The incidence of gastric cancer, colorectal cancer, laryngeal cancer, lung cancer, testicular cancer, kidney cancer, lung cancer, lymphocytic leukaemia and myeloid leukaemia is higher in diabetic males in rural areas than the incidence in the urban population. The incidence of the malignancies liver cancer, malignant skin melanoma, malignant skin, prostate cancer, urinary bladder cancer and multiple myeloma in male diabetic patients living in urban areas is higher than the incidence in rural areas.

Relationship between type 2 diabetes mellitus and markers of cutaneous melanoma aggressiveness: an observational multicentric study in 443 patients with melanoma*

“…The association between T2DM and a greater incidence of cancer has been observed in several studies and has been specifically corroborated for several types of tumours, 8–12 but the relationship of T2DM with cutaneous melanoma remains controversial. A recent meta‐analysis of nine cohort studies concluded that T2DM might be an independent risk factor for malignant melanoma, even when the results were adjusted for age and obesity.…”

“…7 Patients with T2DM increasingly present several types of solid tumours, although there have also been reports of a paradoxical reduction in the incidence of prostate cancer. [8][9][10][11][12] However, the relationship between T2DM and cutaneous melanoma has scarcely been studied. A recent meta-analysis has suggested that T2DM represents a risk factor for melanoma, although the findings of each study included in the meta-analysis were inconsistent.…”

“…Type 2 diabetes mellitus (T2DM) accounts for 90–95% of all diagnosed cases of diabetes and, in parallel with the worldwide escalation in the prevalence of obesity, T2DM is becoming increasingly common on a global scale 7 . Patients with T2DM increasingly present several types of solid tumours, although there have also been reports of a paradoxical reduction in the incidence of prostate cancer 8–12 …”

Cardiovascular risk factors among cancer patients qualified for systemic treatment. Analysis of a cardiovascular disease-free cohort from the Polish multicentre study ONCOECHO

“…Arterial hypertension and diabetes mellitus are well known as risk factors for anthracycline-induced cardiotoxicity [13]. Wierzba et al showed correlation between different types of cancers and diabetes both in urban and rural areas [14].…”

Long-term analysis of occurrence of malignant lip, oral cavity and pharyngeal cancer in Poland

“…The method used is the secondary statistical analysis of data reported to the national payer -the National Health Fund (NFZ) by medical institutions with an indicated diagnosis of lip, oral cavity and pharyngeal cancer in the years 2008-2017 based on ICD-10 classification of diseases. This method has been already used for similar analyses [5][6][7][8]. The analysis included all the reported information on interventions in patients undergoing therapy after a diagnosis of lip, oral cavity and pharyngeal cancer (according to ICD-10 = C00.X -C14.X [9, 10] as the main reason for the intervention; the NFZ databases record all patients whose therapy was financed from the public funds).…”