Comparison of the Incidence of De Novo Solid Malignancies After Heart Transplantation to That in the General Population

Kellerman, Lisa; Neugut, Alfred I.; Burke, B.; Mancini, Donna

doi:10.1016/j.amjcard.2008.10.026

Cited by 51 publications

(38 citation statements)

References 19 publications

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“…The pattern of site-specific cancer risk by transplanted organ was broadly similar, and also largely consistent with prior population-based evidence for liver (7,9,12,15,(33)(34)(35)(36) and heart (8,15,37) transplantation. Our study adds to existing evidence showing an increased risk of NHL, Kaposi sarcoma, colorectal cancer, lip cancer and cancer of unknown primary site after liver transplantation.…”

Section: Discussionsupporting

confidence: 63%

Comparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients

Grulich

Meagher

et al. 2013

American Journal of Transplantation

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Population-based evidence on the relative risk of de novo cancer in liver and cardiothoracic transplant recipients is limited. A cohort study was conducted in Australia using population-based liver (n = 1926) and cardiothoracic (n = 2718) registries (1984-2006). Standardized incidence ratios (SIRs) were computed by cancer type, transplanted organ and recipient age. Cox regression models were used to compare cancer incidence by transplanted organ. During a median 5-year follow-up, the risk of any cancer in liver and cardiothoracic recipients was significantly elevated compared to the general population (n = 499; SIR = 2.62, 95%CI 2.40-2.86). An excess risk was observed for 16 cancer types, predominantly cancers with a viral etiology. The pattern of risk by cancer type was broadly similar for heart, lung and liver recipients, except for Merkel cell carcinoma (cardiothoracic only). Seventeen cancers (10 non-Hodgkin lymphomas), were observed in 415 pediatric recipients (SIR = 23.8, 95%CI 13.8-38.0). The adjusted hazard ratio for any cancer in all recipients was higher in heart compared to liver (1.29, 95%CI 1.03-1.63) and lung compared to liver (1.65, 95%CI 1.26-2.16). Understanding the factors responsible for the higher cancer incidence in cardiothoracic compared to liver recipients has the potential to lead to targeted cancer prevention strategies in this high-risk population.

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Section: Discussionsupporting

confidence: 63%

Comparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients

Grulich

Meagher

et al. 2013

American Journal of Transplantation

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“…[4] They also showed in their series that 14 out of 15 patients with elevated PSA had CaP, with only one patient having chronic prostatitis. [4] In a report by Kelerman et al .,[8] the researchers compared the occurrence of de novo solid organ malignancies developing in patients following cardiac transplantation with that in the general population. These authors reported that the three most frequent cancers diagnosed in decreasing order were of the prostate, lung and breast.…”

Section: Discussionmentioning

confidence: 99%

Robot-assisted laparoscopic radical prostatectomy after heart transplantation

Patel¹,

Thohan²,

Hemal³

2013

Urol Ann

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Prostate cancer (CaP) is the leading visceral malignancy in males. Patients who undergo cardiac transplantation are immune compromised, thus presenting a therapeutic challenge. Immunosuppresion could accelerate tumor growth, while medical intervention may be associated with increased treatment mortality or morbidity. Due to paucity of such cases, there are no randomized trials that address the treatment algorithm for cardiac transplant patients with CaP, with only a few scattered reports in the literature. Treatment options range from hormonal manipulation to radiation therapy to radical prostatectomy. To our knowledge, we report the first successful robot-assisted laparoscopic radical prostatectomy in a heart transplant patient with CaP.

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“…Tumors significantly increase morbidity and mortality of these patients [62]. Epidemiological studies showed that heart transplanted patients, in long term, develop solid organ tumors, skin cancer and hemolymphoproliferative diseases [64].…”

Section: Non Immunological Factorsmentioning

confidence: 99%