In this chapter, power losses and mass of optimally designed Si-vs. SiC-based isolated DC-DC converters are compared in quantitative terms. To that end, an adapted version of a computer-aided design tool, previously published by the authors, is used. The database of the existing tool was completed with new wide band gap semiconductor devices currently available from manufacturers. The results are presented for two switch-mode power supplies, each constituted of an isolated DC-DC converter, operating at very different power levels a kW auxiliary railway power supply and a multiple output . W power supply intended for a space application. The gains in terms of power losses and mass from one technology to the other can advantageously be evaluated thanks to the developed tool.