Comparison of the measurement of lipids and lipoproteins versus assay of apolipoprotein B for estimation of coronary heart disease risk: a study in familial combined hyperlipidemia

Demacker, P.N.M.; Veerkamp, M.J.; Bredie, S.J.H.; Marcovina, Santica M.; Graaf, Jacqueline de; Stalenhoef, Anton F. H.

doi:10.1016/s0021-9150(00)00432-9

Cited by 68 publications

(40 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum TG concentration has been suggested to be the most important predictor of LDL size in FCH patients. 23 In both earlier studies 9,24 and this study, we have confirmed that plasma TG levels Ͼ1.5 mmol/L distinguish optimally between atherogenic small, dense LDL and a large, buoyant LDL subfraction profile.…”

Section: Small Dense Ldl and Tg Levels As Diagnostic Features Of Fchsupporting

confidence: 76%

See 1 more Smart Citation

Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study

Veerkamp¹,

Graaf²,

Hendriks³

2004

ACC Current Journal Review

View full text Add to dashboard Cite

Section: Small Dense Ldl and Tg Levels As Diagnostic Features Of Fchsupporting

confidence: 76%

“…Total plasma apoB concentrations were determined by immunonephelometry. 9 Coefficient of variation estimates of the analytical and biological variation of apoB in our laboratory were Ͻ7%. LDL subfractions were separated by single spin density gradient ultracentrifugation.…”

Section: Plasma Lipid Lipoprotein and Apolipoprotein Analysesmentioning

confidence: 79%

Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study

Veerkamp¹,

Graaf²,

Hendriks³

2004

ACC Current Journal Review

View full text Add to dashboard Cite

“…9,11 ). A value 1.2 g/L for apoB was chosen, because at this level the cardiovascular risk rapidly increased 9,12 . This value corresponds to the 75 th percentile of the North American population, the level chosen to define an elevated LDL-C (ref.…”

Section: Study Design and Subjectsmentioning

confidence: 99%

Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

Karásek

Vaverková²,

Halenka³

et al. 2013

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

Introduction. Like hypertension, prehypertension is associated with cardiovascular disease. Aims. The aim of this study was to evaluate: a) the prevalence of prehypertension/hypertension in individuals with various dyslipidemic phenotypes; b) the relation between blood pressure (BP) and other risk factors for atherosclerosis; c) atherogenic potential of prehypertension by the assessment of intima-media thickness of the arteria carotis communis (IMT). Methods. 667 clinically asymptomatic subjects were divided into four dyslipidemic phenotypes (DLP) according to apolipoprotein B (apoB) and triglycerides (TG): DLP1 (n=198, normo-apoB/normo-TG), DLP2 (n=179, normo-apoB/ hyper-TG), DLP3 (n=87, hyper-apoB/normo-TG), DLP4 (n=203, hyper-apoB/hyper-TG). DLP1 served as a control group. Results. There was significantly higher prevalence of prehypertension and hypertension in subjects with dyslipidemia (DLP2 43.0%, 41.3%; DLP3 42.5%, 29.9%; DLP4 42.4%, 47.8%) than in normolipidemic individuals (DLP1 32.8%, 20.2%). Systolic and diastolic blood pressure (SBP + DBP) correlated with age, total cholesterol, TG, non-HDL-cholesterol, body mass index and waist circumference; SBP additionally with C-peptide, fasting glycemia; DBP additionally with apoB, homeostasis model assessment (HOMA) and plasminogen activator inhibitor-1. The IMT of hypertensive and of prehypertensive subjects was higher than that of subjects with normal BP in all DLPs. Conclusions. The prevalence of prehypertension was higher in all dyslipidemic patients. The common prevalence of prehypertension/hypertension was highest in the hypertriglyceridemic subjects. Prehypertensive and hypertensive patients had higher IMT than normotensive individuals in all DLPs.

show abstract

“…38 Total plasma apo B concentrations were determined by immunonephelometry. 39 LDL subfractions were separated by single spin density gradient ultracentrifugation. A continuous variable K represents the LDL subfraction profile of each individual.…”

Section: Biochemical Analysesmentioning

confidence: 99%

The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia

et al. 2006

View full text Add to dashboard Cite

Objective: Familial combined hyperlipidemia (FCH) is characterized by elevated levels of total cholesterol (TC), triglycerides (TG) and apolipoprotein B (apo B) and is associated with premature cardiovascular disease (CVD). Other features of FCH are obesity and insulin resistance. Serum leptin levels have also been associated with obesity, insulin resistance and atherosclerosis. Leptin exerts its effect through the leptin receptor (LEPR). The aim of this study is to determine whether the Gln223Arg polymorphism in the LEPR gene contributes to FCH and its associated phenotypes. Methods: The study population consists of 37 families, comprising 644 subjects, of whom 158 subjects were diagnosed as FCH. The FCH diagnosis was based on plasma TC and TG levels, adjusted for age and gender, and absolute apo B levels, according to our recently published nomogram. The Gln223Arg polymorphism was studied by restriction fragment length polymorphism-PCR. Results: Carriers of one or two Arg alleles had an increased risk of FCH, compared to subjects homozygous for the Gln allele (OR ¼ 1.6 [95% CI 1.0-2.4]). A difference in high-density lipoprotein cholesterol (HDL-c) levels was present between carriers and non-carriers of an Arg allele, 1.21 vs 1.28 mmol/l, respectively (P ¼ 0.04), but no differences in obesity, insulin resistance and other lipid parameters were found. Conclusion: The Gln223Arg polymorphism in the LEPR gene is associated with FCH, which is supported by a significant association between HDL-c levels and the LEPR gene.

show abstract

Comparison of the measurement of lipids and lipoproteins versus assay of apolipoprotein B for estimation of coronary heart disease risk: a study in familial combined hyperlipidemia

Cited by 68 publications

References 31 publications

Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study

Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study

Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia

Contact Info

Product

Resources

About