Comparison of the mechanical destructive force in the small intestine of dog and human

Kamba, Masaharu; Seta, Yasuo; Kusai, Akira; Nishimura, Kenji

doi:10.1016/s0378-5173(02)00043-1

Cited by 66 publications

(27 citation statements)

References 19 publications

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“…Therefore, it seemed that the difference of gastrointestinal agitation intensity might affect the T max of the erosible controlled-release tablet. Also, Kamba et al [22][23][24] studied the mechanical destructive force in the stomach and the small intestine of dogs and humans and suggested that this force in the stomach is stronger in dogs, while that of the small intestine in the two species is within the same range.…”

Section: )mentioning

confidence: 99%

Suitability of the Cynomolgus Monkey as an Animal Model for Drug Absorption Studies of Oral Dosage Forms from the Viewpoint of Gastrointestinal Physiology

Ikegami

Tagawa

Narisawa

et al. 2003

Biological & Pharmaceutical Bulletin

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Section: )mentioning

confidence: 99%

Suitability of the Cynomolgus Monkey as an Animal Model for Drug Absorption Studies of Oral Dosage Forms from the Viewpoint of Gastrointestinal Physiology

Ikegami

Tagawa

Narisawa

et al. 2003

Biological & Pharmaceutical Bulletin

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“…The movement of tablets during this phase is rapid and tablets are subject to increased mechanical stress, especially during gastric emptying (10,11). The destructive forces in the human stomach and small intestine were measured using a "Destructive forceDependent Release System", and the results obtained were 1.9 and 1.2 N, respectively (12). Theoretically, each matrix tablet with a swollen gel layer should be able to resist these mechanical forces in order to achieve the desired release profile.…”

Section: Introductionmentioning

confidence: 99%

Correlating Cellulose Derivative Intrinsic Viscosity with Mechanical Susceptibility of Swollen Hydrophilic Matrix Tablets

Klančar¹,

Horvat²,

Baumgartner

2012

AAPS PharmSciTech

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Abstract. Hydrophilic matrix tablets are prone to mechanical stress while passing through the gastrointestinal tract, which may result in inappropriate drug-release characteristics. Intrinsic viscosity is a physical polymer property that can be directly compared across various types and grades of polymers and correlated with the mechanical susceptibility of swollen matrix tablets. Five tablet formulations containing different HPMC and HPC polymers were prepared and analyzed using an in vitro glass bead manipulation test. The dissolution rate results were modeled using the Korsmeyer-Peppas equation and a correlation was found between the fit constants k and n, goodness-of-fit measure parameters, and intrinsic viscosity. Moreover, the dissolution profiles were used to calculate the degree of mechanical susceptibility for each formulation, defined as the ratio of the average dissolution rate after manipulation and the initial dissolution rate before manipulation. It was confirmed that an increased intrinsic viscosity polymer value resulted in a decrease in mechanical susceptibility. Considering this, two simple rules were defined for designing robust matrix tablets with respect to mechanical stresses.

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“…Appropriate dissolution medium hydrodynamics are necessary to optimize the likelihood of successfully developing good in vitro-in vivo correlations (IVIVCs), [1][2][3] particularly for immediate release products. In situations where dissolution is the ratedetermining step controlling absorption, the fluid hydrodynamics will influence the dissolution rate and hence the rate of absorption.…”

Section: Introductionmentioning

confidence: 99%

Simulating the hydrodynamic conditions in the united states pharmacopeia paddle dissolution apparatus

et al. 2003

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KEYWORDS: computational fluid dynamics (CFD), USP paddle apparatus, dissolution, hydrodynamics, modeling The objective of this work was to examine the feasibility of developing a high-performance computing software system to simulate the United States Pharmacopeia (USP) dissolution apparatus 2 (paddle apparatus) and thus aid in characterizing the fluid hydrodynamics in the method. The USP apparatus was modeled using the hydrodynamic package Fluent. The Gambit program was used to create a "wireframe" of the apparatus and generate the 3-dimensional grids for the computational fluid dynamics solver. The Fluent solver was run on an IBM RS/6000 SP distributed memory parallel processor system, using 8 processors.Configurations with and without a tablet present were developed and examined. Simulations for a liquidfilled vessel at a paddle speed of 50 rpm were generated. Large variations in fluid velocity magnitudes with position in the vessel were evident. Fluid velocity predictions were in good agreement with those previously published, using laser Doppler velocity measurements. A low-velocity domain was evident directly below the center of the rotating paddle. The model was extended to simulate the impact of the presence of a cylindrical tablet in the base of the dissolution vessel. The presence of the tablet complicated the local fluid flow, and large fluid shear rates were evident at the base of the compact. Fluid shear rates varied depending on the tablet surface and the location on the surface and were consistent with the reported asymmetrical dissolution of model tablets. The approach has the potential to explain the variable dissolution results reported and to aid in the design/prediction of optimal dissolution conditions for in vitro-in vivo correlations.

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Comparison of the mechanical destructive force in the small intestine of dog and human

Cited by 66 publications

References 19 publications

Suitability of the Cynomolgus Monkey as an Animal Model for Drug Absorption Studies of Oral Dosage Forms from the Viewpoint of Gastrointestinal Physiology

Suitability of the Cynomolgus Monkey as an Animal Model for Drug Absorption Studies of Oral Dosage Forms from the Viewpoint of Gastrointestinal Physiology

Correlating Cellulose Derivative Intrinsic Viscosity with Mechanical Susceptibility of Swollen Hydrophilic Matrix Tablets

Simulating the hydrodynamic conditions in the united states pharmacopeia paddle dissolution apparatus

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