Comparison of the MoCA and BEARNI tests for detection of cognitive impairment in in-patients with alcohol use disorders

Pelletier, Stéphanie; Alarcon, Régis; Ewert, Valérie; Forest, Margot; Nalpas, Bertrand; Perney, Pascal

doi:10.1016/j.drugalcdep.2018.02.026

Cited by 20 publications

(32 citation statements)

References 27 publications

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“…BEARNI (Ritz et al, 2015) is a validated screening tool that has been especially designed to detect neuropsychological impairments in AUD. Given its reliability in the detection of moderate-to-severe impairments in AUD patients without neurological complications (Pelletier et al, 2018;Ritz et al, 2015), the aim of the present study was to determine whether BEARNI is a relevant tool for the early identification of AUD patients at risk of developing KS. Overall, 14 analyses showed a significant effect of group with a graded effect of impairments: KS patients had lower performance than both AUD patients and HC, who differed between each other.…”

Section: Discussionmentioning

confidence: 99%

“…The aim of this screening tool is to identify AUD patients with mild or moderate-to-severe neuropsychological impairments, who should be referred to a psychologist for a comprehensive neuropsychological evaluation and treatment adjustments based on their neuropsychological profile. Studies conducted in AUD patients without neurological complications showed that BEARNI has excellent sensitivity and specificity to detect moderateto-severe neuropsychological impairments (Pelletier et al, 2018;Ritz et al, 2015) compared with other brief screening tools, such as the Mini Mental State Examination (Ritz et al, 2015), Mattis Dementia Rating Scale (Ritz et al, 2015) and MOCA (Pelletier et al, 2018;Wester et al, 2013). A recent study compared the psychometric properties of the BEARNI and MOCA, a brief screening tool already used in AUD patients (Alarcon et al, 2015;Copersino et al, 2012Copersino et al, , 2009Pelletier et al, 2018;Wester et al, 2013) but initially designed to detect cognitive decline 4 associated with Alzheimer disease or other types of dementia.…”

Section: Introductionmentioning

confidence: 99%

“…Results indicated that AUD and KS patients differed from healthy controls on the MOCA total score only, and no optimal cut-off score could be determined to discriminate the two patient groups. BEARNI has proven to be more relevant than MOCA to discriminate AUD patients with mild deficits from those with moderate-to-severe impairments (Pelletier et al, 2018) and may thus be relevant to identify KS patients. The aim of the present study is to determine whether BEARNI is a relevant tool for the early identification of AUD patients at risk of developing KS.…”

Section: Introductionmentioning

confidence: 99%

“…The BEARNI was found to be more relevant than the MOCA to identify AUD patients with moderate‐to‐severe impairments. Patients with mild deficits and those with moderate‐to‐severe impairments did not differ from each other on the MOCA (Pelletier et al, 2018). Results on BEARNI were also found to be reliable predictors of performance on an extensive neuropsychological battery assessing episodic memory, working memory, executive functions, visuospatial abilities, and ataxia (Ritz et al, 2015).…”

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confidence: 99%

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Early Identification of Alcohol Use Disorder Patients at Risk of Developing Korsakoff’s Syndrome

Ritz

Lanièpce

Cabé

et al. 2021

Alcoholism Clin & Exp Res

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Background: The aim of the present study was to determine whether the Brief Evaluation of Alcohol-Related Neuropsychological Impairments (BEARNI), a screening tool developed to identify neuropsychological deficits in Alcohol Use Disorder (AUD) patients, can also be used as a relevant tool for the early identification of AUD patients at risk of developing Korsakoff's syndrome (KS). Methods: Eighteen KS patients, 47 AUD patients and 27 healthy controls underwent BEARNI (including five subtests targeting episodic memory, working memory, executive function, visuospatial abilities and ataxia) and a comprehensive neuropsychological examination. Results: Performance of AUD and KS patients on BEARNI subtests is in accordance with the results on the standardized neuropsychological assessment. On BEARNI, ataxia and working memory deficits observed in AUD were as severe as those exhibited by KS patients, whereas for visuospatial abilities, a graded effect of performance was found. On the opposite, the subtests involving long-term memory abilities (episodic memory and fluency) were impaired in KS patients only. AUD patients with a score lower than 1.5 points (/6) on the episodic memory subtest of BEARNI could be considered at risk of developing KS and exhibited the lowest episodic memory performance on the neuropsychological battery. Conclusions: These findings suggest that BEARNI is a relevant tool to detect severe memory impairments, thus making early identification of AUD patients at high risk of developing KS possible.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Early Identification of Alcohol Use Disorder Patients at Risk of Developing Korsakoff’s Syndrome

Ritz

Lanièpce

Cabé

et al. 2021

Alcoholism Clin & Exp Res

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“…Both tests may provide equally, if not superior, screening capabilities to the ACE-III and RBANS for ARBD detection, though neither test has been specifically validated for the screening of clinically diagnosed alcohol-related neurocognitive disorders (e.g., KS, ARBD). The BEARNI was found to have very high sensitivity (100%) for detecting individuals with cognitive impairment (as determine by detailed neuropsychological assessment) within a sample of ALs, although the specificity of the test was very poor (4%; Pelletier et al, 2018). In the same sample, the MoCA demonstrated 79% sensitivity and 65% specificity.…”

Section: Discussionmentioning

confidence: 98%

Applicability of the ACE-III and RBANS Cognitive Tests for the Detection of Alcohol-Related Brain Damage

Brown

Heirene

Gareth-Roderique-Davies

et al. 2019

Front. Psychol.

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Background and AimsRecent investigations have highlighted the value of neuropsychological testing for the assessment and screening of Alcohol-Related Brain Damage (ARBD). The aim of the present study was to evaluate the suitability of the Addenbrooke’s Cognitive Examination (ACE-III) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for this purpose.MethodsComparing 28 participants with ARBD (11 with Korsakoff’s Syndrome and 17 with the umbrella “ARBD” diagnosis) and 30 alcohol-dependent participants without ARBD (ALs) we calculated Area Under the Curve (AUC) statistics, sensitivity and specificity values, base-rate adjusted predictive values, and likelihood ratios for both tests.ResultsHigh levels of screening accuracy were found for the total scores of both the ACE-III (AUC = 0.823, 95% CIs [0.714, 0.932], SE = 0.056; optimal cut-off ≤86: sensitivity = 82%, specificity = 73%) and RBANS (AUC = 0.846, 95% CIs [0.746, 0.947], SE = 0.052; optimal cut-off ≤83: sensitivity = 89%, specificity = 67%) at multiple cut-off points. Removing participants with a history of polysubstance from the samples (10 ALs and 1 ARBD) improved the diagnostic capabilities of the RBANS substantially (AUC = 0.915, 95% CIs [0.831, 0.999], SE = 0.043; optimal cut-off ≤85: sensitivity = 98%, specificity = 80%), while only minor improvements to the ACE-III’s accuracy were observed (AUC = 0.854, 95% CIs [0.744, 0.963], SE = 0.056; optimal cut-off ≤88: sensitivity = 85%, specificity = 75%).ConclusionOverall, both the ACE-III and RBANS are suitable tools for ARBD screening within an alcohol-dependent population, though the RBANS is the superior of the two. Clinicians using these tools for ARBD screening should be cautious of false-positive outcomes and should therefore combine them with other assessment methods (e.g., neuroimaging, clinical observations) and more detailed neuropsychological testing before reaching diagnostic decisions.

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Structural brain substrates of the deficits observed on the BEARNI test in alcohol use disorder and Korsakoff's syndrome

Ritz

Segobin

Lanièpce

et al. 2022

J of Neuroscience Research

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Chronic and excessive alcohol consumption can result in alcohol use disorder (AUD) without neurological complications and in Korsakoff's syndrome (KS) when combined with thiamine deficiency. These two clinical forms are accompanied by widespread structural brain damage in both the fronto-cerebellar (FCC) and Papez circuits (PC) as well as in the parietal cortex, resulting in cognitive and motor deficits. BEARNI is a screening tool especially designed to detect neuropsychological impairments in AUD.However, the sensitivity of this tool to the structural brain damage of AUD and KS patients remains unknown. Eighteen KS patients, 47 AUD patients and 27 healthy controls (HC) underwent the BEARNI test and a 3 T-MRI examination. Multiple regression analyses conducted between GM density and performance on each BEARNI subtest revealed correlations with regions included in the FCC, PC, thalamus and posterior cortex (precuneus and calcarine regions). All these brain regions were altered in KS compared to HC, in agreement with the cognitive deficits observed in the corresponding BEARNI subtests. The comparison between KS and AUD regarding the GM density in the several nodes of the FCC and calcarine regions revealed that they were atrophied to the same extent, suggesting that BEARNI is sensitive to the severity of alcohol-related GM abnormalities. Within the PC, the density of the cingulate cortex and thalamus, which correlated with the memory and fluency subscores, was smaller in KS than in AUD, suggesting that BEARNI is sensitive to specific brain abnormalities occurring in KS.

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Comparison of the MoCA and BEARNI tests for detection of cognitive impairment in in-patients with alcohol use disorders

Cited by 20 publications

References 27 publications

Early Identification of Alcohol Use Disorder Patients at Risk of Developing Korsakoff’s Syndrome

Early Identification of Alcohol Use Disorder Patients at Risk of Developing Korsakoff’s Syndrome

Applicability of the ACE-III and RBANS Cognitive Tests for the Detection of Alcohol-Related Brain Damage

Structural brain substrates of the deficits observed on the BEARNI test in alcohol use disorder and Korsakoff's syndrome

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