Comparison of the nutrient composition of royal jelly and worker jelly of honey bees (Apis mellifera)

Wang, Ying; Ma, Liming; Zhang, Weixing; Cui, Xuepei; Wang, Hongfang; Xu, Baojun

doi:10.1007/s13592-015-0374-x

Cited by 93 publications

(107 citation statements)

References 29 publications

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“…The inhibitory metal binding site on zinc metalloenzymes has been proposed as a potential regulatory mechanism as well [40]. It is interesting to note that the royal jelly fed to queen larvae is significantly higher in zinc content than jelly fed to developing worker bees [3] and the queen is fed royal jelly throughout her life. In addition, the important zinc-binding protein vitellogenin has been positively correlated to high zinc levels, low juvenile hormone, decreased foraging, and longer lifespan in Apis mellifera [41-46].…”

Section: Discussionmentioning

confidence: 99%

“…As oxidative stress increases, levels of juvenile hormone increase resulting in increased foraging behavior and an increase in dietary iron and zinc. The two largest quantities of divalent metals found in worker jelly and royal jelly are zinc and iron with royal jelly possessing significantly greater quantities of zinc than worker jelly [3]. It is also possible that an increased level of Zn(II)-HDAC over Fe(II)-HDAC form would lead to a decrease in oxidative stress and an increase in longevity.…”

Section: Discussionmentioning

confidence: 99%

“…Though the IC50 and K i are high, the concentration of 10-HDA present in royal jelly is approximately 100mM (at a minimum). A level significantly higher than in worker jelly [3]. Also, the developing queen is fed royal jelly throughout her life providing further support for its role in differentiation and maintenance of health and longevity of the queen.…”

Section: Discussionmentioning

confidence: 99%

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Regulation of Histone Deacetylase 3 by Metal Cations and 10-Hydroxy-2E-DecenoicAcid: Possible Molecular Epigenetic Mechanisms of Queen-Worker Bee Differentiation

Polsinelli

2018

Preprint

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Histone deacetylases (HDACs) catalyze the hydrolysis of ε-acetyl-lysine residues of histones. Removal of acetyl groups results in condensation of chromatin structure and repression of gene expression. Human class I, II, and IV HDACs are said to be zinc-dependent in that they require divalent zinc ions to catalyze the deacetylase reaction. HDACs are considered potential targets for the treatment of cancer due to their role in regulating transcription. They are also thought to play important roles in the development of organisms such as honey bees. The fatty acid, 10-hydroxy-2E-decenoic acid (10-HDA), which can account for up to 5% of royal jelly composition has been reported as an HDAC inhibitor. The crystal structure of the HDAC3:SMRT complex possesses two monovalent cations (MVCs) labeled as potassium with one MVC binding site near the active site Zn(II) and the second MVC binding site ≥20 Å from the active site Zn(II). We report here the inhibitory effects of excess Zn(II) on the catalytic activity of histone deacetylase 3 (HDAC3) bound to the deacetylase activating domain of nuclear receptor corepressor 2 (NCOR2). We also report the effects of varying concentrations of potassium ions where [K+] up to 10 mM increase HDAC3 activity with a maximum kcat/KM of approximately 80,000 M-1s-1 while [K+] above 10 mM inhibit HDAC3 activity. The inhibition constant (Ki) of 10-HDA was determined to be 5.32 mM. The regulatory effects of zinc, potassium, and 10-HDA concentration on HDAC3 activity suggest a strong correlation between these chemical species and epigenetic control over Apis mellifera caste differentiation among other control mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Regulation of Histone Deacetylase 3 by Metal Cations and 10-Hydroxy-2E-DecenoicAcid: Possible Molecular Epigenetic Mechanisms of Queen-Worker Bee Differentiation

Polsinelli

2018

Preprint

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“…It contains mainly water (~65%), crude protein (~12%), and monosaccharides (glucose and fructose) (~10%). The remainder is composed of an ether-soluble fraction of fatty acids, primarily (E)-10-hydroxy-2-decenoic acid (10HDA), a compound associated epigenetic regulation of queen-bee development (Spannhoff et al, 2011;Wang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of gibberellic acid on the queen cell production and queen performance in colonies of Apis mellifera L. (Hymenoptera: Apidae)

Szawarski¹,

Revainera²,

Mitton³

et al. 2019

Rev. Soc. Entomol. Arg.

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Efecto del ácido giberélico en la producción de celdas reales y el rendimiento de la reina en colonias de Apis mellifera L. (Hymenoptera: Apidae) RESUMEN. Para la abeja melífera (Apis mellifera L.), la recompensa por la polinización es la obtención de alimento: néctar, una solución azucarada, o polen, que contiene un alto porcentaje de proteínas y lípidos. También hay otras recompensas florales ecológicamente relevantes, las resinas, y/o componentes minoritarios, como las fitohormonas y polifenoles. En la cría de reinas de A. mellifera diversos factores afectan el éxito de los traslarves: la edad de las larvas, el diseño y la posición de las celdas reales artificiales, el cebado de las cúpulas con jalea real o la alimentación de la colonia que criará las reinas. El objetivo de nuestro estudio fue evaluar el efecto de dos fitohormonas, ácido giberélico (GA) y ácido indoalacético (IAA) en colonias de A. mellifera sobre la producción de celdas reales, desarrollo de las glándulas hipofaríngeas de abejas nodrizas y desempeño de abejas reinas. Los resultados indican que el tratamiento con GA en colonias sometidas al método de semiorfandad para la cría de reinas, mejoró la eficiencia de la producción de las mismas y su rendimiento reproductivo en colonias de A. mellifera. Estos resultados apoyan el potencial de utilizar metabolitos vegetales como suplementos dietarios para mejorar los métodos de producción de abejas reinas y su desempeño en las colonias. PALABRAS CLAVE. Abeja melífera. Cría de reinas. Fitomoléculas. Suplemento alimentario.ABSTRACT. For honey bees (Apis mellifera L.), the reward for pollination service is obtaining food: nectar, a sugar solution; or pollen, which contains a high percentage of proteins and lipids. There are also other floral rewards ecologically relevant for pollinators, like resins, and/or minor components, such as phytohormones and polyphenols. When rearing A. mellifera queens, several factors affect grafting success: age of the grafted larvae, design and position of the artificial queen cells, priming queen cells with royal jelly before grafting, or nutrition of the queen rearing colony. This study aimed to evaluate the effect of two phytohormones: gibberellic acid (GA) and indole acetic acid (IAA) on queen cell production, the development of hypopharyngeal glands of nurse bees, and the performance of queen bees in colonies of www.biotaxa.org/RSEA. ISSN 1851-7471 (online) Revista de la Sociedad Entomológica Argentina 78(3): 15-21, 2019 Copyright SZAWARSKI, N. et al.-This is an open access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0) 15A. mellifera. The results indicate that GA positively influences queens production efficiency in vertical orphaned colonies and their reproductive performances in honey bee colonies. These results support the potential of plant metabolites as dietary supplements to improve queen bee production methods and their performance in colonies as well.

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“…The levels of different sugars (e.g., glucose and fructose) in the diet provided to honey bee female larvae change over the course of the first three larval instars when the larvae are totipotent Lensky 1985, 1988). While newly hatched worker larvae receive glandular secretions (worker jelly) with low levels of sugars that gradually rise through the larval instars, queen larvae receive a diet composed of higher sugar levels throughout the larval stage (Wang et al 2016). Moreover, regulatory factors of physiological pathways in caste determination have been described through the integration of nutrient-sensing systems, in which the insulin-insulin-like signaling (IIS) and target-ofrapamycin (TOR) pathways play key roles in translating external nutritional signals to internal signals, biasing a larva's fate to the queen or worker adult phenotype (Patel et al 2007;Mutti et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Experimental improvement of honey bee (Apis mellifera) queen quality through nutritional and hormonal supplementation

Souza¹,

Huang²

2018

Apidologie

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Queen reproductive potential (=quality) impacts the health and productivity of honey bee colonies. To determine the factors that affect reproductive quality during development, we tested queens produced under larval treatments by supplementing the diet with juvenile hormone (JH), additional sugars, or both, compared to untreated control. Furthermore, we varied the age of the larvae that were grafted (1 and 3 days old). We analyzed newly emerged virgin queens for their morphological characters as proxies for their reproductive potential. We found that the application of a sugar-enriched diet in combination with JH application onto 1st instar queen larvae produced higher-quality queens, while for 3rd instar larvae only the JH treatment resulted in increasing queen quality. For mated queens, those treated with JH plus supplemented sugars showed a significantly higher sperm count and sperm viability. Our findings demonstrate that honey bee queen reproductive potential can be increased through diet supplementation.honeybee queens / queen quality / geometric morphometry / queen larval diet / juvenile hormone

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Comparison of the nutrient composition of royal jelly and worker jelly of honey bees (Apis mellifera)

Cited by 93 publications

References 29 publications

Regulation of Histone Deacetylase 3 by Metal Cations and 10-Hydroxy-2E-DecenoicAcid: Possible Molecular Epigenetic Mechanisms of Queen-Worker Bee Differentiation

Regulation of Histone Deacetylase 3 by Metal Cations and 10-Hydroxy-2E-DecenoicAcid: Possible Molecular Epigenetic Mechanisms of Queen-Worker Bee Differentiation

Effect of gibberellic acid on the queen cell production and queen performance in colonies of Apis mellifera L. (Hymenoptera: Apidae)

Experimental improvement of honey bee (Apis mellifera) queen quality through nutritional and hormonal supplementation

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