Comparison of the oral (PABA) pancreatic function test, the secretin-pancreozymin test and endoscopic retrograde pancreatography in chronic alcohol induced pancreatitis.

Mee, Anthony S.; Girdwood, A. H.; Walker, Edward A.; Gilinsky, Norman H.; Kottler, R. E.; Marks, I. N.

doi:10.1136/gut.26.11.1257

Cited by 14 publications

(9 citation statements)

References 22 publications

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“…21 It has been used as an alternative diag-nostic tool for exocrine pancreatic insufficiency with reasonable sensitivity and specificity. [22][23][24][25] The PABA test has been compared with the other frequently used method of indirect assessment of exocrine pancreatic function, namely the pancreolauryl test, and has been found to be similar. 26,27 Lankisch et al concluded that the sensitivity and specificity of the PABA test were comparable with those of the pancreolauryl test in patients with pancreatic steatorrhoea.…”

Section: Discussionmentioning

confidence: 99%

A prospective, comparative study of the para‐aminobenzoic acid test and faecal elastase 1 in the assessment of exocrine pancreatic function

Sonwalkar

Holbrook

Phillips

et al. 2003

Aliment Pharmacol Ther

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SUMMARYBackground: The assessment of exocrine pancreatic insufficiency is part of the routine work-up of patients with persistent diarrhoea or suspected steatorrhoea. Direct and indirect tests for the diagnosis of exocrine pancreatic insufficiency have their drawbacks. Measurement of faecal elastase 1 by enzyme-linked immunoabsorbent assay is a simple, non-invasive, robust test for exocrine pancreatic insufficiency. Methods: We performed a prospective comparison of the para-aminobenzoic acid test and faecal elastase 1 test in 45 patients being investigated for diarrhoea or suspected steatorrhoea. Details of clinical suspicion, imaging and response to treatment were recorded. Results: Exocrine pancreatic function was normal in 20 patients with normal para-aminobenzoic acid and faecal elastase 1 levels. Eight patients had exocrine pancreatic

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Section: Discussionmentioning

confidence: 99%

A prospective, comparative study of the para‐aminobenzoic acid test and faecal elastase 1 in the assessment of exocrine pancreatic function

Sonwalkar

Holbrook

Phillips

et al. 2003

Aliment Pharmacol Ther

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“…Several comprehensive reviews highlighting the differing methods have been published recently. 2 • 1 [3][4][5][6][7][8][9][10][11][12][13][14][15] Available evidence s~ests that stimulants (secretin alone or in combination with cholecystokinin being the most widely utilized) are best administered by constant intravenous infusion at rates producing maximal secretion. 14 When overall responses are evaluated by discriminant analysis, the correct diagnosis can be made in 92% of cases 16 and patients with mild chronic pancreatitis can be differentiated from controls.…”

Section: Direct (Intubation) Testsmentioning

confidence: 99%

Pancreatic function testing

Gilinsky¹

1989

Postgraduate Medicine

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The diagnosis of chronic pancreatitis is ideally established by an appropriate clinical history and confirmatory radiologic imaging. However, in cases where imaging results are normal or equivocal, pancreatic function testing is necessary. Direct (intubation) tests are generally accepted as the best methods for study of pancreatic exocrine capacity, but indirect tests, which are well tolerated and generally simple to perform, are gaining interest. Their shortcoming is that they are too insensitive to reliably differentiate patients with early exocrine dysfunction (ie, before malabsorption has occurred) from controls. Sensitivity is not improved by combining two or more studies. However, several modified tests (eg, two-stage paraaminobenzoic acid test, pancreolauryl test) have improved specificity and are able to distinguish pancreatic from other causes of steatorrhea. Their reproducibility in individual cases is of value in sequential studies and in patients with established pancreatic exocrine deficiency to seek evidence of improvement or deterioration in function and to determine patient compliance with replacement therapy.

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“…PABAX testing [11] is based on several principles. N-benzoyltyrosylparaaminobenzoic acid (bentiromide) is a synthetic peptide that has been used to assess pancreatic sufficiency [15,24,23,4,16]. When this peptide is exposed to endogenous chymotrypsin following oral administration, paraaminobenzoic acid (PABA) is released, which can then be measured in urine or blood to screen for maldigestion.…”

Section: Introductionmentioning

confidence: 99%

Assessment of gastrointestinal function and response to megesterol acetate in subjects with gastrointestinal cancers and weight loss

Deutsch

Kolhouse

2004

Support Care Cancer

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Comparison of the oral (PABA) pancreatic function test, the secretin-pancreozymin test and endoscopic retrograde pancreatography in chronic alcohol induced pancreatitis.

Cited by 14 publications

References 22 publications

A prospective, comparative study of the para‐aminobenzoic acid test and faecal elastase 1 in the assessment of exocrine pancreatic function

A prospective, comparative study of the para‐aminobenzoic acid test and faecal elastase 1 in the assessment of exocrine pancreatic function

Pancreatic function testing

Assessment of gastrointestinal function and response to megesterol acetate in subjects with gastrointestinal cancers and weight loss

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