“…It is known that stressful life events and increased emotional state can both trigger relapse and increase relapse rates (Butzlaff and Hooley, 1998;Nuechterlein et al, 1994). Psychosocial factors also have an effect, with socially isolated patients and those of lower socio-economic position having higher rates of relapse (Bland and Orn, 1980;McKenzie et al, 2001). Moreover, the inefficacy and poor tolerability of typical antipsychotic medication can be responsible for relapse (Gerlach, 2002;Tattan and Creed, 2001), as can non-concordance with treatment, which can be particularly difficult to assess and follow up in patients with schizophrenia (Oehl et al, 2000).…”