Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey

Eguchi, Susumu; Kanematsu, Takashi; Arii, Shigeki; Okazaki, Masanori; Okita, Kiwamu; Omata, Masao; Ikai, Iwao; Kudo, Masatoshi; Kojiro, Masamichi; Makuuchi, Masatoshi; Monden, Morito; Matsuyama, Yutaka; Nakanuma, Yasuni; Takayasu, Kenichi

doi:10.1016/j.surg.2007.12.003

Cited by 352 publications

(234 citation statements)

References 8 publications

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“…5,7,20,21,23,27,34,35 The mortality rate related to surgical resection was 3.1%, which is comparable to other studies (0%-15%). [36][37][38][39] These results demonstrate that RFA combined with TACE is safe.…”

Section: Discussionmentioning

confidence: 61%

Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

Kagawa

Koizumi

Kojima

et al. 2010

Cancer

104

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the Tokai RFA Study Group BACKGROUND: Radiofrequency ablation (RFA) is becoming a well-known local therapy for hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) is expected to enhance the effects of subsequent RFA by reducing arterial blood flow. However, the long-term efficacy of this combined therapy has not been elucidated. In this study, the survival rates of patients who received TACE combined with RFA (TACE þ RFA) were compared with those of patients treated surgically. METHODS: The study included consecutive patients who received TACE þ RFA or surgical resection as the initial curative treatment for HCC between 2000 and 2005 at Tokai University Hospital. Inclusion criteria were a single HCC 50 mm or up to 3 HCCs 30 mm, presence of cirrhosis classified as Child-Pugh class A, no vascular invasion, and no extrahepatic metastasis. RESULTS: Sixty-two patients (23 women, 39 men; aged 67.5 AE 8.4 years [mean AE standard deviation]) received TACE þ RFA, and 55 patients (15 women, 40 men; aged 66.1 AE 8.4 years) underwent surgical resection. Median follow-up periods were similar (50 months in the TACE þ RFA group vs 49 months in the resection group). The probabilities of overall survival at 1, 3, and 5 years in the TACE þ RFA group (100%, 94.8%, and 64.6%, respectively) were similar (P ¼ .788) to those in the resection group (92.5%, 82.7%, and 76.9%, respectively). Two major RFA-related complications were observed (1.5%). CONCLUSIONS: RFA combined with TACE is an efficient and safe treatment that provides overall survival rates similar to those achieved with surgical resection. Cancer 2010;116;3638-44.

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Section: Discussionmentioning

confidence: 61%

Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

Kagawa

Koizumi

Kojima

et al. 2010

Cancer

104

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“…[1][2][3] However, when HCC recurs and further treatment is no longer possible, liver transplantation (LT) may be considered as salvage LT. 4 There are drawbacks of pre-LT treatment for HCC during the waiting period. Dissemination 5 and implantation 6 may occur after puncture of HCC and they may form tumors after the administration of immunosuppressive drugs.…”

Section: Introductionmentioning

confidence: 99%

Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation

et al. 2009

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“…In an analysis of 434 patients from Japan, anatomic resections could be performed in only 36% of patients with multinodular HCC while 71% of patients had undergone anatomical resections in the presence of a single tumor [7] . Although the risk of intrahepatic disseminations is considered trivial in small tumors under 2 cm, it may be challenging to justify resection in the treatment of multinodular HCC for the anatomic resection advocates [17] . Nathan et al [18] analyzed the factors predictive of receipt of surgical treatment for early HCC that is, those patients with non-metastatic tumors 5 cm or smaller and without evidence of lymph node metastasis, extrahepatic tumor growth, or major vascular invasion.…”

Section: Textmentioning

confidence: 99%

Role of liver resection in the management of multinodular hepatocellular carcinoma

Abbasoğlu

2015

WJH

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cause of cancer related deaths worldwide. Various treatment modalities have been applied to HCC depend ing on the tumor load, functional capacity of the liver and the general condition of the patient. According to Barcelona Clinic Liver Cancer staging strategy and The American Association for the Study of Liver Disease guidelines, surgical resection is not advocated in the tretment of multinodular HCC. Despite this, many recent clinical studies show that, resection can achieve good results in patients with multinodular HCC and 5year survival rate around 40% can be reached. If resection or transplantation is not performed, these patients are usually managed with palliative procedures such as transarterial chemoembolization, radioembolization and cytotoxic chemotherapy and 5year survival of this group of patients will be extremely low. Although survival rates are lower and complications may be increased in this group of patients, liver resection can safely be performed in selected patients in experienced centers for the management of multinodular HCC. Core tip: Liver resection is underutilized in the management of multinodular hepatocellular carcinoma. The presence of multiple nodules should not be considered as a contraindication for surgical resection. Acceptable 5year survival rates can be achieved in selected patients. Conflictofinterest statement:The author whose name is listed immediately below certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers' bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patentlicensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey

Cited by 352 publications

References 8 publications

Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation

Role of liver resection in the management of multinodular hepatocellular carcinoma

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