Comparison of the ovarian and uterine reproductive parameters, and the ovarian <scp>mRNA</scp> and protein expression of <scp>LHR</scp> and <scp>FSHR</scp> between the prepubertal and adult female cats

Mehl, N.S.; Khalid, M.; Srisuwatanasagul, Sayamon; Swangchan-Uthai, Theerawat; Sirivaidyapong, S.

doi:10.1111/rda.12926

Cited by 7 publications

(8 citation statements)

References 6 publications

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“…During prepubertal development, ovarian size progressively increased up to 31 ± 3.1 weeks of age. This is similar to a previous report in which the ovarian weight of 3‐month‐old prepubertal cats was significantly lower than that of adult cats (Mehl, Khalid, Srisuwatanasagul, Swangchan‐Uthai, & Sirivaidyapong, ). Another report in prepubertal cats stated that ovarian weight increased rapidly until 3–4 months old when the study was concluded (Uchikura, Nagano, & Hishinuma, ).…”

Section: Discussionsupporting

confidence: 91%

“…This is in agreement with changes in prepubertal cows and gilts, where a positive relationship between the number of antral follicles and the size of the ovaries was found (Honaramooz et al, 2004;Lents, Cushman, & Freking, 2014). Coincident with this, histological studies in prepubertal cats stated that the increase in ovarian weight was accompanied by the increase in the number and size of antral follicles (Uchikura et al, 2010;Mehl et al, 2017). In adult mammals, it has been postulated that numerous follicles are present in the ovaries at all times and the follicles destined to ovulate begin to enlarge about mid-cycle, showing a sudden enlargement just after the onset of heat (Evans, 2003).…”

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 87%

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Ultrasonographic evaluation of ovarian morphology and blood flow in prepubertal and pubertal cats

Vercellini

Gobello

D'Francisco

et al. 2018

Reprod Domestic Animals

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The aim of this study was to evaluate two‐dimensional and Doppler ultrasonographic changes of feline ovaries before and during puberty. Nine, 3‐month‐old female cats were followed until puberty (Day 1). Two‐dimensional and Doppler ultrasound evaluations of the ovaries were carried out on Days ‐50, ‐20, ‐7 and 1. Longitudinal and transverse sections of the ovaries were measured and all anechoic spherical structures were considered to be follicles. The number of follicles >1 mm and the maximum diameter of the largest follicle were recorded. Peak systolic velocity and end diastolic velocity of intraovarian arteries were also measured to automatically calculate the resistive index (RI). The mean ovarian longitudinal diameter increased gradually throughout the study from 8.6 to 10.7 mm (p < 0.05). While four cats presented multiple anechoic spherical structures <1 mm diameter throughout the study, the remaining five animals had these structures only on Days ‐50 and ‐20. On Days ‐20, ‐7 and 1, the mean number of follicles were 1.4 ± 0.7, 2.5 ± 0.8 and 4.8 ± 1 respectively (p < 0.01). The largest follicles at the same time points were 1.1 ± 0.2 mm, 1.9 ± 0.3 mm and 2.6 ± 0.5 mm respectively (p < 0.05). The RI of the intraovarian arteries declined throughout the study period (p < 0.01). It is concluded that, in female cats, ovarian dimensions, follicle number and intraovarian blood flow increased from 3 months of age to puberty.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 87%

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Ultrasonographic evaluation of ovarian morphology and blood flow in prepubertal and pubertal cats

Vercellini

Gobello

D'Francisco

et al. 2018

Reprod Domestic Animals

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“…These structures may correspond to early antral follicles, which have been histologically described in the feline ovary throughout the estrous cycle. 36,37 In all these queens, >1 mm antral follicles were ultrasonographically detected on AE5.…”

Section: Discussionmentioning

confidence: 90%

Ovarian and uterine two-dimensional and Doppler ultrasonographic changes in the feline peri-estrus period

Vercellini

Blanco

Arizmendi

et al. 2021

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to evaluate two-dimensional and Doppler ultrasonographic changes of the ovary and uterus during estrus and the early post-estrus period in domestic cats. Methods Two-dimensional and Doppler ultrasonographic evaluations of the ovaries and uterus were performed in seven queens on days 1, 3 and 5 of estrus, and 5 days after estrus (AE5). Results On day 1, 5.4 ± 0.5 follicles of 2.1 ± 0.1 mm were detected progressively increasing in number and size up to day 5 and then decreased on AE5 ( P <0.05). A maximum follicular diameter of 4.1 ± 0.1 mm was achieved on day 5. Both during and after estrus, the uterus was generally hypoechoic compared with the surrounding tissues and delineated by a thin hyperechoic line corresponding to the serosa. In some animals, the uterine layers were distinguished during and after estrus. The blood flow waveforms of the intraovarian and uterine arteries were characterized by a systolic peak and diastolic flow extending throughout the remainder of the cardiac cycle to the next systole. In the uterine artery waveforms, the early diastolic notch was mild or absent during most estrous observations. The resistance index of the intraovarian arteries decreased up to day 5, and then increased on AE5 ( P <0.05). The resistance index of the uterine arteries was lower during estrus than in the post-estrus period ( P <0.05). Conclusions and relevance It is concluded that in the domestic cat, follicular number and diameter as well as ovarian and uterine blood flow changed during and immediately after estrus. Doppler ultrasound proved suitable to evaluate the hemodynamic changes involved in the cyclic remodeling of ovarian and uterine tissues that occurs during and after follicular growth in domestic cats.

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“…In ovarian follicles in the early antral period, the FSHR expression is restricted to the granulosa cells, while LHR is expressed in theca cells but also granulosa cells of large follicles (>800 µm in diameter) and CLs [74,75]. When comparing prepubertal and adult cats, no differences are observed in the ovarian gene expression of FSHR and LHR or the LHR protein.…”

Section: Ovarymentioning

confidence: 92%

Molecular Factors Involved in the Reproductive Morphophysiology of Female Domestic Cat (Felis catus)

Santos,

Silva

2023

Animals

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The domestic cat (Felis catus) is considered an important model for the study of feline reproductive morphophysiology. However, although the morphological changes and clinical signs that occur during the estrous cycle and pregnancy are well known, little is known about the molecular mechanisms involved in the reproductive physiology of this animal species. Thus, this paper reviews the current knowledge about the modulation and expression profile of hormonal, immunological, redox, and growth mediators involved in the uterine, ovarian, and placental morphophysiology of domestic cats.

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Comparison of the ovarian and uterine reproductive parameters, and the ovarian mRNA and protein expression of LHR and FSHR between the prepubertal and adult female cats

Cited by 7 publications

References 6 publications

Ultrasonographic evaluation of ovarian morphology and blood flow in prepubertal and pubertal cats

Ultrasonographic evaluation of ovarian morphology and blood flow in prepubertal and pubertal cats

Ovarian and uterine two-dimensional and Doppler ultrasonographic changes in the feline peri-estrus period

Molecular Factors Involved in the Reproductive Morphophysiology of Female Domestic Cat (Felis catus)

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