Comparison of the participation rate between CT colonography and colonoscopy in screening population: a systematic review and meta-analysis of randomized controlled trials

Abstract

Objective: To compare the participation rate between CT colonography (CTC) and colonoscopy in screening population in randomized controlled trials (RCTs). Methods: A search was performed using the PubMed, Web of Science, and Cochrane databases. RCTs that included screening populations and reported participation number were assessed. Cochrane risk of bias tool was used to assess the bias and quality. Risk ratio (RR) was used to present the results. The non-participation rate was analyzed to verify the results of participation rate. Results: Five of 760 studies, with a total of 15,974 invitees, were included. The participation rate was higher at CTC (28.8%) than colonoscopy (20.8%), although the difference did not reach statistical significance (RR = 1.26; p = 0.070; I2 = 90.3%). The non-participation rate at CTC was significantly lower than colonoscopy (RR = 0.92; p = 0.012; I2 = 86.7%). Subgroup analysis suggested both the participation and non-participation rate were with significant difference between reduced/no cathartic preparation CTC and colonoscopy. Cumulative meta-analysis showed both the participation rate and non-participation rate exhibited a trend over time and sample size. Conclusion: The participation rate was higher at CTC than colonoscopy, although the difference did not reach statistical significance. But the non-participation rate was with statistical difference. Screening population seemed more likely to participate the reduced/no cathartic preparation CTC. Statistical evidence was provided for more large RCTs are needed in the future. Advances in knowledge: The screening populations seem more likely to participate in the CTC, especially the reduced/no cathartic preparation CTC. The statistical evidence was provided for more large RCTs are needed in the future.

Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan

“…In our study, we achieved an overall good participation rate (56.5%), with better engagement of women (63.4%) and of the 50-60 age group for both sexes (38% of all participants). These results indicate an improvement from the previously published data, where the overall participation rate of CTC screening was 25% [ 18 , 23 ]. It should be noted, however, that participants’ sociodemographic and health status characteristics, as well as bowel preparation techniques in these referenced trials, are different from ours.…”

“…These results indicate an improvement from the previously published data, where the overall participation rate of CTC screening was 25%. 18,23 It should be noted, however, that participants' sociodemographic and health status characteristics, as well as bowel preparation techniques in these referenced trials, are different from ours.…”

CT Colonography and Colorectal Carcinoma: Current Trends and Emerging Developments

“…Zhu et al showed that CTC had a higher patient participation rate than OC, although the difference was not statistically significant [54]. The rate of non-participation, on the other hand, was statistically significant.…”

“…The screening population appeared to be more likely to participate in the CTC with minimal or no cathartic preparation [54]. According to statistical evidence, more large randomized controlled trials (RCTs) will be required in the future [54].…”

“…The screening population appeared to be more likely to participate in the CTC with minimal or no cathartic preparation [54]. According to statistical evidence, more large randomized controlled trials (RCTs) will be required in the future [54]. However, because the CTC has been validated for CRC screening, the decision on which method to utilize should be made in collaboration with patients, taking into account their preferences as studied by Duarte et al [18].…”