Comparison of the performance of SOFA, qSOFA and SIRS for predicting mortality and organ failure among sepsis patients admitted to the intensive care unit in a middle-income country

Khwannimit, Bodin; Bhurayanontachai, Rungsun; Vattanavanit, Veerapong

doi:10.1016/j.jcrc.2017.10.023

Cited by 97 publications

(86 citation statements)

References 31 publications

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“…The patient to critical care health care professionals and better access to advanced diagnostics and critical care therapies at AKUH, N critical care units likely explains the difference in mortality rate. The average length of critical care stay was four days in our cohort similar to other studies to Raith, et al [8], Khwannimit, et al [9] and Seymour, et al [10]. The overall hospital length of stay was longer in the Khwannimit, et al [9] cohort with an average length of hospital stay of 16 days compared to this study cohort's 8 days, likely due to differences in patient characteristics with an older patient pollution in the Khwannimit, et al [9].…”

Section: Severity Of Illness and Outcomesupporting

confidence: 91%

“…The MRSA prevalence of < 10% is similar to a study at AKUH, N in 2014, that showed a prevalence of 4.8% [19] and other African countries like in Madagascar with 4.4% [20]. The commonest organism was E. coli followed by K. pneumonia similar to both Raith, et al [8] and Khwannimit, et al [9] cohorts. We had a high proportion of prevalence of ESBL producing bacteria among our gram-negative isolates (44.1%) compared to 2.6% in most parts of Europe [21].…”

Section: Severity Of Illness and Outcomesupporting

confidence: 84%

“…The commonest source of infection was the respiratory system followed by urinary tract source in keeping with Seymour, et al [10], Raith, et al [8] and Khwannimit, et al [9]. There is a low MRSA prevalence in this study at 9% compared to higher income countries, like USA with a prevalence of 41% [18].…”

Section: Severity Of Illness and Outcomesupporting

confidence: 79%

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Comparison of the Sequential Organ Failure Assessment (SOFA) and Quick SOFA Scores in Predicting in-Hospital Mortality among Adult Critical Care Patients with Suspected Infection

A¹,

Wangari-Waweru²,

Mung’ayi³

et al. 2019

Int J Crit Care Emerg Med

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Introduction: Sepsis is global health priority and the leading cause of death in critical care. The SEPSIS 3 criteria introduced in 2016 is the latest tool in diagnosing sepsis. It uses SOFA and qSOFA scores in place of the SIRS criteria for better ability to predict mortality in patients with suspected infections. The performance of these scores in critical care units outside high-income countries remains largely unknown. Methods: We compared the performance of SOFA and qSOFA in predicting the in-hospital mortality of an adult critical care unit in Kenya. We conducted a retrospective review of all patients admitted to the critical care units with suspected infection between 1 January 2017 and 31 December 2017. A standardized electronic data collection tool was be used to collect demographic, clinical and outcome data on the participants. Area under the receiver operating characteristic curves (AUROC) with 95% confidence intervals was used to compare SOFA and qSOFA. Results: We enrolled 450 patients with a mean age of 56 years [SD ± 19.10] and 57.60% were male. Majority of the patients, 352 (78.20%), presented through the emergency department. Pneumonia was the commonest source of infection 293 (65.10%). There were 92 deaths (mortality rate of 20.44%). The majority of patients, 371 (82.44%) manifested a SOFA score of ≥ 2 and 190 (42.22%) had a qSOFA score of ≥ 2. SOFA score was superior in predicting in hospital mortality compared to qSOFA with an AUROC = 0.799 [0.752-0.846] vs. 0.694 [0.691-0.748, P < 0.001]. Conclusion: A SOFA score of two or more is better than qSOFA score in predicting in-hospital mortality among adult critical care patients with suspected infection. This finding suggests that SOFA is an appropriate tool in the initial diagnosis sepsis in critical care setting in a developing country.

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Section: Severity Of Illness and Outcomesupporting

confidence: 91%

Section: Severity Of Illness and Outcomesupporting

confidence: 84%

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Comparison of the Sequential Organ Failure Assessment (SOFA) and Quick SOFA Scores in Predicting in-Hospital Mortality among Adult Critical Care Patients with Suspected Infection

A¹,

Wangari-Waweru²,

Mung’ayi³

et al. 2019

Int J Crit Care Emerg Med

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“…Considering the large population in China, sepsis will be a great threat to people's life and a heavy burden on the health care system. Therefore, early identi cation and timely prevention will undoubtedly improve the prognosis of patients with sepsis [41] Researches showed that multiple factors, including patient admission scores, patients comorbid disease and demographic indicators like age, gender, race, were capable of affecting the prognosis of patients with sepsis, accompanied by numerous laboratory indexes such as neutrophil to lymphocyte ratio, platelet, albumin, procalcitonin, C-reactive protein, creatinine, urea nitrogen and lactate [38,39,[42][43][44][45][46][47] . Continuous monitoring of these indicators is conducive to early identi cation and timely treatment of septic patients.…”

Section: Discussionmentioning

confidence: 99%

Aspartate transaminase/alanine transaminase ratio as a significant prognostic factor in patients with sepsis: a retrospective analysis

Zhao

Yao

Ren

et al. 2020

Preprint

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Background: The study was performed to investigate the relationship between aspartate transaminase/alanine transaminase ratio (DRR) and long-term mortality among patients diagnosed with sepsis or septic shock. Methods: We conducted a retrospective study among adult septic patients who were admitted to surgical intensive care unit (ICU) of the Chinese People's Liberation Army (PLA) General Hospital from January 2014 to December 2018. Baseline characteristics were compared between survivors and non-survivors. We applied univariate as well as multivariate Cox regression analyses to evaluate DRR in relation to 180-day mortality. The potential prognostic value of DRR in predicting mortality rate was assessed by receiver operating curve (ROC) analysis. Besides, we conducted subgroup analysis by stratifying patients via optimal DRR cut-off value. Results: We included a total number of 183 patients in the current study, 44 (24%) patients died within 180-day hospitalization. Univariate and multivariate Cox analysis revealed that DRR was an independent predictor of 180-day mortality (hazard ratio [HR] 1.421, 95% confidence interval [CI] 1.073-1.883, P = 0.014). The predicting accuracy of 180-day mortality for DRR was presented as ROC with an area under the curve (AUC) of 0.708 (95% CI 0.629–0.786, P < 0.001). As we stratified all enrolled patients into two groups by using the optimal cut-off value of 1.29, we observed a significantly higher mortality in patients with relatively high DRR. Conclusions: An elevated DRR was associated with higher 180-day mortality among septic patients, and DRR might be an optimal marker for predicting the long-term mortality of sepsis. More prospective and randomized trials are needed to confirm the prognostic value of DRR.

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“…The qSOFA criteria contain Glasgow Coma Scale score of less than or equal to 13, systolic blood pressure less than or equal to 100 mm Hg, and respiratory rate greater than or equal to 22 per minute for the sepsis [9]. Many studies were performed for the usability of qSOFA defined after the Sepsis-3, especially in sepsis patients [10][11][12]. Since the qSOFA score reflects the multiple organ dysfunctions, it can show better performance in the diseases such as sepsis infectious and in the diseases such as multiple traumas in which the multiple organ dysfunctions are seen.…”

Section: Introductionmentioning

confidence: 99%

Use of qSOFA criteria in prediction of poor prognosis in acute pancreatitis

Göktekin¹

2019

Ann Clin Anal Med

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Aim: In this study,we aimed to investigate the usability of SOFA and qSOFA criteria in predicting the conditions by which the poor prognosis such as hospitalization in the intensive care unit, long length of hospital stay and death was observed for the patients receiving a diagnosis of acute pancreatitis in the emergency department. Material and Method: The data of 98 patients with acute pancreatitis diagnosis which was verified by the computerized abdominal tomography in the university hospital emergency department between 2013 and 2018 were used in our study. that was designed as monocenteric retrospective study. The SOFA and qSOFA criteria of the patients were calculated during the application to the emergency department. Results: Fifty-three percent (n=52) of the patients were female. Their age averages were 57.5±18.57/year. Forty-eight (%49.0) patients were detected to have any of the poor prognostic criteria. It was also detected that the qSOFA score of 17 (517.3) patients were 1 and above and the qSOFA score of 81 (582.7) patients was 0 during the application to the emergency department. The SOFA (p<0.001) and qSOFA (p=0.004) values were significantly different for the patients having the good prognosis and poor prognosis. When we take the Cutoff as > 0 for the qSOFA criteria, we determined the AUC as 0.641, Sensitivity as %39.58, Specificity as %86, and CI% as 0.538 to 0.735, and p=0.001, respectively. Discussion: The SOFA and qSOFA criteria used in order to predict the organ failure in the sepsis can be a scoring system that will be able to be used in predicting the poor prognosis in acute pancreatitis in the emergency department.

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Comparison of the performance of SOFA, qSOFA and SIRS for predicting mortality and organ failure among sepsis patients admitted to the intensive care unit in a middle-income country

Cited by 97 publications

References 31 publications

Comparison of the Sequential Organ Failure Assessment (SOFA) and Quick SOFA Scores in Predicting in-Hospital Mortality among Adult Critical Care Patients with Suspected Infection

Comparison of the Sequential Organ Failure Assessment (SOFA) and Quick SOFA Scores in Predicting in-Hospital Mortality among Adult Critical Care Patients with Suspected Infection

Aspartate transaminase/alanine transaminase ratio as a significant prognostic factor in patients with sepsis: a retrospective analysis

Use of qSOFA criteria in prediction of poor prognosis in acute pancreatitis

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